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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Shewchuk, L.M."

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Search Summary

This query matches 42 Structures.

Refinements

Structure Determination Methodology

experimental (42)

Scientific Name of Source Organism

	Homo sapiens (38)
	Escherichia coli (2)
	Drosophila melanogaster (1)
	Rattus norvegicus (1)

Taxonomy

	Eukaryota (40)
	Bacteria (2)
	Eukaryota (eukaryotes) (1)

Experimental Method

X-RAY DIFFRACTION (42)

Polymer Entity Type

Protein (42)

Refinement Resolution (Å)

	1.5 - 2.0 (4)
	2.0 - 2.5 (22)
	2.5 - 3.0 (12)
	3.0 - 3.5 (4)

Release Date

	1990 - 1994 (2)
	2000 - 2004 (11)
	2005 - 2009 (9)
	2010 - 2014 (3)
	2015 - 2019 (11)
	2020 - 2024 (6)

Enzyme Classification Name

	Transferases (27)
	Hydrolases (14)
	Isomerases (3)
	Ligases (2)

Symmetry Type

	Asymmetric (35)
	Cyclic (8)

SCOP Classification

	Alpha and beta proteins (a+b) (26)
	All alpha proteins (8)
	Alpha and beta proteins (a/b) (7)
	Artifacts (3)
	All beta proteins (2)

AllSelected

1 to 25 of 42 Structures

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1BIA \| pdb_00001bia	Download File View File

THE E. COLI BIOTIN HOLOENZYME SYNTHETASE(SLASH)BIO REPRESSOR CRYSTAL STRUCTURE DELINEATES THE BIOTIN AND DNA-BINDING DOMAINS

Wilson, K.P., Shewchuk, L.M., Matthews, B.W.

(1992) Proc Natl Acad Sci U S A 89: 9257-9261

Released	1993-10-31
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Escherichia coli
Macromolecule	BirA BIFUNCTIONAL PROTEIN (protein)

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1BIB \| pdb_00001bib	Download File View File

THE E. COLI BIOTIN HOLOENZYME SYNTHETASE(SLASH)BIO REPRESSOR CRYSTAL STRUCTURE DELINEATES THE BIOTIN AND DNA-BINDING DOMAINS

Wilson, K.P., Shewchuk, L.M., Matthews, B.W.

(1992) Proc Natl Acad Sci U S A 89: 9257-9261

Released	1993-10-31
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Escherichia coli
Macromolecule	BIR A (protein)
Unique Ligands	BTN

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1FVR \| pdb_00001fvr	Download File View File

TIE2 KINASE DOMAIN

Shewchuk, L.M., Hassell, A.M., Ellis, B., Holmes, W.D., Davis, R., Horne, E.L., Kadwell, S.H., McKee, D.D., Moore, J.T.

(2000) Structure 8: 1105-1113

Released	2001-09-20
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	TYROSINE-PROTEIN KINASE TIE-2 (protein)

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1KE5 \| pdb_00001ke5	Download File View File

CDK2 complexed with N-methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide

Bramson, H.N., Corona, J., Davis, S.T., Dickerson, S.H., Edelstein, M., Frye, S.V., Gampe, R.T., Hassell, A.M., Shewchuk, L.M., Kuyper, L.F.

(2001) J Med Chem 44: 4339-4358

Released	2002-05-14
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein)
Unique Ligands	LS1

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1KE6 \| pdb_00001ke6	Download File View File

CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE

Bramson, H.N., Corona, J., Davis, S.T., Dickerson, S.H., Edelstein, M., Frye, S.V., Gampe, R.T., Hassell, A.H., Shewchuk, L.M., Kuyper, L.F.

(2001) J Med Chem 44: 4339-4358

Released	2002-05-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein)
Unique Ligands	LS2

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1KE7 \| pdb_00001ke7	Download File View File

CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE

Bramson, H.N., Corona, J., Davis, S.T., Dickerson, S.H., Edelstein, M., Frye, S.V., Gampe, R.T., Hassell, A.H., Shewchuk, L.M., Kuyper, L.F.

(2001) J Med Chem 44: 4339-4358

Released	2002-05-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein)
Unique Ligands	LS3

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1KE8 \| pdb_00001ke8	Download File View File

CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE

Bramson, H.N., Corona, J., Davis, S.T., Dickerson, S.H., Edelstein, M., Frye, S.V., Gampe, R.T., Hassell, A.M., Shewchuk, L.M., Kuyper, L.F.

(2001) J Med Chem 44: 4339-4358

Released	2002-05-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	CELL DIVISION PROTEIN KINASE 2 (protein)
Unique Ligands	LS4

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1KE9 \| pdb_00001ke9	Download File View File

CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[4-({[AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE

Bramson, H.N., Corona, J., Davis, S.T., Dickerson, S.H., Edelstein, M., Frye, S.V., Gampe, R.T., Hassell, A.M., Shewchuk, L.M., Kuyper, L.F.

(2001) J Med Chem 44: 4339-4358

Released	2002-05-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein)
Unique Ligands	LS5

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1PDU \| pdb_00001pdu	Download File View File

Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

Baker, K.D., Shewchuk, L.M., Korlova, T., Makishima, M., Hassell, A.M., Wisely, B., Caravella, J.A., Lambert, M.H., Wilson, T.M., Mangelsdorf, D.J.

(2003) Cell 113: 731-742

Released	2003-06-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Drosophila melanogaster
Macromolecule	nuclear hormone receptor HR38 (protein)

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1Q6K \| pdb_00001q6k	Download File View File

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate

Catalano, J.G., Deaton, D.N., Furfine, E.S., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M., Willard, D.H., Wright, L.L.

(2004) Bioorg Med Chem Lett 14: 275-278

Released	2004-03-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	SO4, TCO

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1SNK \| pdb_00001snk	Download File View File

Cathepsin K complexed with carbamate derivatized norleucine aldehyde

Boros, E.E., Deaton, D.N., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M., Thompson, J.B., Willard Jr., D.H., Wright, L.L.

(2004) Bioorg Med Chem Lett 14: 3425-3429

Released	2004-06-22
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	MYE, SO4

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1TU6 \| pdb_00001tu6	Download File View File

Cathepsin K complexed with a ketoamide inhibitor

Barrett, D.G., Catalano, J.G., Deaton, D.N., Hassell, A.M., Long, S.T., Miller, A.B., Miller, L.R., Shewchuk, L.M., Wells-Knecht, K.J., Wright, L.L.

(2004) Bioorg Med Chem Lett 14: 4897-4902

Released	2004-09-21
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	FSP, SO4

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1XKK \| pdb_00001xkk	Download File View File

EGFR kinase domain complexed with a quinazoline inhibitor- GW572016

Wood, E.R., Truesdale, A.T., McDonald, O.B., Yuan, D., Hassell, A., Dickerson, S.H., Ellis, B., Pennisi, C., Horne, E., Lackey, K., Alligood, K.J., Rusnak, D.W., Gilmer, T.M., Shewchuk, L.M.

(2004) Cancer Res 64: 6652-6659

Released	2004-12-07
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	FMM, PO4

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1YK7 \| pdb_00001yk7	Download File View File

Cathepsin K complexed with a cyanopyrrolidine inhibitor

Barrett, D.G., Deaton, D.N., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M., Tavares, F.X., Willard, D.H., Wright, L.L.

(2005) Bioorg Med Chem Lett 15: 1815-1819

Released	2005-03-22
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	NBL

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1YK8 \| pdb_00001yk8	Download File View File

Cathepsin K complexed with a cyanamide-based inhibitor

Barrett, D.G., Deaton, D.N., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Payne, J.A., Shewchuk, L.M., Willard, D.H., Wright, L.L.

(2005) Bioorg Med Chem Lett 15: 3039-3043

Released	2005-07-19
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	T2M

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1YT7 \| pdb_00001yt7	Download File View File

Cathepsin K complexed with a constrained ketoamide inhibitor

Barrett, D.G., Boncek, V.M., Catalano, J.G., Deaton, D.N., Hassell, A.M., Jurgensen, C.H., Long, S.T., McFadyen, R.B., Miller, A.B., Miller, L.R., Payne, J.A., Ray, J.A., Samano, V., Shewchuk, L.M., Tavares, F.X., Wells-Knecht, K.J., Willard, D.H., Wright, L.L., Zhou, H.Q.

(2005) Bioorg Med Chem Lett 15: 3540-3546

Released	2005-07-19
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	3FC, SO4

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2AUX \| pdb_00002aux	Download File View File

Cathepsin K complexed with a semicarbazone inhibitor

Adkison, K.K., Barrett, D.G., Deaton, D.N., Gampe, R.T., Hassell, A.M., Long, S.T., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M.

(2006) Bioorg Med Chem Lett 16: 978-983

Released	2006-08-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	CT1

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2AUZ \| pdb_00002auz	Download File View File

Cathepsin K complexed with a semicarbazone inhibitor

Adkison, K.K., Barrett, D.G., Deaton, D.N., Gampe, R.T., Hassell, A.M., Long, S.T., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M.

(2006) Bioorg Med Chem Lett 16: 978-983

Released	2006-08-08
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	CT2, SO4

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2BDL \| pdb_00002bdl	Download File View File

Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor

Shewchuk, L.M.

(2006) Bioorg Med Chem Lett 16: 1735-1739

Released	2006-03-21
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Cathepsin K (protein)
Unique Ligands	4PR

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2I40 \| pdb_00002i40	Download File View File

Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor

Shewchuk, L.M.

(2006) Bioorg Med Chem Lett 16: 6236-6240

Released	2006-10-10
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein) Cyclin-A2 (protein)
Unique Ligands	BLZ

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2R4B \| pdb_00002r4b	Download File View File

ErbB4 kinase domain complexed with a thienopyrimidine inhibitor

Shewchuk, L.M., Uehling, D.E.

(2008) Proc Natl Acad Sci U S A 105: 2773-2778

Released	2008-03-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Receptor tyrosine-protein kinase erbB-4 (protein)
Unique Ligands	GW7

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3CLD \| pdb_00003cld	Download File View File

Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate

Shewchuk, L.M., McLay, I., Stewart, E., Biggadike, K.B., Hassell, A.M., Bledsoe, R.K.

(2008) J Med Chem 51: 3349-3352

Released	2008-06-24
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens
Macromolecule	Glucocorticoid receptor (protein) Tif2 coactivator motif (protein)
Unique Ligands	GW6