QUERY: Structure Author = "Tisi, D."
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Search Summary This query matches 58 Structures.
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1 to 25 of 58 Structures
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1DY2 | pdb_00001dy2

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Murine collagen alpha1(XV), endostatin domain

Tisi, D., Hohenester, E., Sasaki, T., Timpl, R.

(2000) J Mol Biology 301: 1179

Released2001-01-21
Method
X-RAY DIFFRACTION 2 Å
Organisms
Macromolecule
Unique LigandsSO4
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1DYK | pdb_00001dyk

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Laminin alpha 2 chain LG4-5 domain pair

Tisi, D., Talts, J.F., Timple, R., Hohenester, E.

(2000) EMBO J 19: 1432

Released2001-02-04
Method
X-RAY DIFFRACTION 2 Å
Organisms
Macromolecule
Unique LigandsCA
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1G0W | pdb_00001g0w

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CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE

Tisi, D., Bax, B., Loew, A.

(2001) Acta Crystallogr D Biol Crystallogr 57: 187-193

Released2001-02-07
Method
X-RAY DIFFRACTION 2.3 Å
Organisms
Macromolecule
Unique LigandsSO4
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1H30 | pdb_00001h30

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C-terminal LG domain pair of human Gas6

Sasaki, T., Knyazev, P.G., Cheburkin, Y., Gohring, W., Tisi, D., Ullrich, A., Timpl, R., Hohenester, E.

(2002) J Biological Chem 277: 44164

Released2003-01-30
Method
X-RAY DIFFRACTION 2.2 Å
Organisms
Macromolecule
Unique LigandsCA, SO4
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1O70 | pdb_00001o70

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Novel Fold Revealed by the Structure of a FAS1 Domain Pair from the Insect Cell Adhesion Molecule Fasciclin I

Clout, N.J., Tisi, D., Hohenester, E.

(2003) Structure 11: 197

Released2003-02-13
Method
X-RAY DIFFRACTION 2.6 Å
Organisms
Macromolecule
FASCICLIN I (protein)
Unique LigandsSO4
Unique branched monosaccharidesNAG
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1OES | pdb_00001oes

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Oxidation state of protein tyrosine phosphatase 1B

van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.

(2003) Nature 423: 773-777

Released2003-06-12
Method
X-RAY DIFFRACTION 2.2 Å
Organisms
Macromolecule
Unique LigandsMG
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1OET | pdb_00001oet

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Oxidation state of protein tyrosine phosphatase 1B

van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.

(2003) Nature 423: 773-777

Released2003-06-12
Method
X-RAY DIFFRACTION 2.3 Å
Organisms
Macromolecule
Unique LigandsMG
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1OEU | pdb_00001oeu

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Oxidation state of protein tyrosine phosphatase 1B

van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.

(2003) Nature 423: 773-777

Released2003-06-12
Method
X-RAY DIFFRACTION 2.5 Å
Organisms
Macromolecule
Unique LigandsMG
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1OEV | pdb_00001oev

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Oxidation state of protein tyrosine phosphatase 1B

van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.

(2003) Nature 423: 773-777

Released2003-06-12
Method
X-RAY DIFFRACTION 2.2 Å
Organisms
Macromolecule
Unique LigandsMG
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1QU0 | pdb_00001qu0

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CRYSTAL STRUCTURE OF THE FIFTH LAMININ G-LIKE MODULE OF THE MOUSE LAMININ ALPHA2 CHAIN

Hohenester, E., Tisi, D., Talts, J.F., Timpl, R.

(1999) Mol Cell 4: 783-792

Released1999-12-03
Method
X-RAY DIFFRACTION 2.35 Å
Organisms
Macromolecule
Unique LigandsCA, SO4
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2JJC | pdb_00002jjc

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Hsp90 alpha ATPase domain with bound small molecule fragment

Congreve, M., Chessari, G., Tisi, D., Woodhead, A.J.

(2008) J Med Chem 51: 3661

Released2008-07-15
Method
X-RAY DIFFRACTION 1.95 Å
Organisms
Macromolecule
Unique LigandsDMS, LGA
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2W1C | pdb_00002w1c

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Structure determination of Aurora Kinase in complex with inhibitor

Howard, S., Berdini, V., Boulstridge, J.A., Carr, M.G., Cross, D.M., Curry, J., Devine, L.A., Early, T.R., Fazal, L., Gill, A.L., Heathcote, M., Maman, S., Matthews, J.E., McMenamin, R.L., Navarro, E.F., O'Brien, M.A., O'Reilly, M., Rees, D.C., Reule, M., Tisi, D., Williams, G., Vinkovic, M., Wyatt, P.G.

(2009) J Med Chem 52: 379

Released2009-01-27
Method
X-RAY DIFFRACTION 3.24 Å
Organisms
Macromolecule
Unique LigandsL0C
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2W1D | pdb_00002w1d

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Structure determination of Aurora Kinase in complex with inhibitor

Howard, S., Berdini, V., Boulstridge, J.A., Carr, M.G., Cross, D.M., Curry, J., Devine, L.A., Early, T.R., Fazal, L., Gill, A.L., Heathcote, M., Maman, S., Matthews, J.E., McMenamin, R.L., Navarro, E.F., O'Brien, M.A., O'Reilly, M., Rees, D.C., Reule, M., Tisi, D., Williams, G., Vinkovic, M., Wyatt, P.G.

(2009) J Med Chem 52: 379

Released2009-01-27
Method
X-RAY DIFFRACTION 2.97 Å
Organisms
Macromolecule
Unique LigandsL0D
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2W1E | pdb_00002w1e

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Structure determination of Aurora Kinase in complex with inhibitor

Howard, S., Berdini, V., Boulstridge, J.A., Carr, M.G., Cross, D.M., Curry, J., Devine, L.A., Early, T.R., Fazal, L., Gill, A.L., Heathcote, M., Maman, S., Matthews, J.E., McMenamin, R.L., Navarro, E.F., O'Brien, M.A., O'Reilly, M., Rees, D.C., Reule, M., Tisi, D., Williams, G., Vinkovic, M., Wyatt, P.G.

(2009) J Med Chem 52: 379

Released2009-01-27
Method
X-RAY DIFFRACTION 2.93 Å
Organisms
Macromolecule
Unique LigandsL0E
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2W1F | pdb_00002w1f

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Structure determination of Aurora Kinase in complex with inhibitor

Howard, S., Berdini, V., Boulstridge, J.A., Carr, M.G., Cross, D.M., Curry, J., Devine, L.A., Early, T.R., Fazal, L., Gill, A.L., Heathcote, M., Maman, S., Matthews, J.E., McMenamin, R.L., Navarro, E.F., O'Brien, M.A., O'Reilly, M., Rees, D.C., Reule, M., Tisi, D., Williams, G., Vinkovic, M., Wyatt, P.G.

(2009) J Med Chem 52: 379

Released2009-01-27
Method
X-RAY DIFFRACTION 2.85 Å
Organisms
Macromolecule
Unique LigandsL0F
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2W1G | pdb_00002w1g

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Structure determination of Aurora Kinase in complex with inhibitor

Howard, S., Berdini, V., Boulstridge, J.A., Carr, M.G., Cross, D.M., Curry, J., Devine, L.A., Early, T.R., Fazal, L., Gill, A.L., Heathcote, M., Maman, S., Matthews, J.E., McMenamin, R.L., Navarro, E.F., O'Brien, M.A., O'Reilly, M., Rees, D.C., Reule, M., Tisi, D., Williams, G., Vinkovic, M., Wyatt, P.G.

(2009) J Med Chem 52: 379

Released2009-01-27
Method
X-RAY DIFFRACTION 2.71 Å
Organisms
Macromolecule
Unique LigandsL0G
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2W1H | pdb_00002w1h

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Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi- targeted Kinase Inhibitor with Potent Aurora Kinase Activity

Howard, S., Berdini, V., Boulstridge, J.A., Carr, M.G., Cross, D.M., Curry, J., Devine, L.A., Early, T.R., Fazal, L., Gill, A.L., Heathcote, M., Maman, S., Matthews, J.E., McMenamin, R.L., Navarro, E.F., O'Brien, M.A., O'Reilly, M., Rees, D.C., Reule, M., Tisi, D., Williams, G., Vinkovic, M., Wyatt, P.G.

(2009) J Med Chem 52: 379

Released2009-01-27
Method
X-RAY DIFFRACTION 2.15 Å
Organisms
Macromolecule
Unique LigandsL0F
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2W1I | pdb_00002w1i

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Structure determination of Aurora Kinase in complex with inhibitor

Howard, S., Berdini, V., Boulstridge, J.A., Carr, M.G., Cross, D.M., Curry, J., Devine, L.A., Early, T.R., Fazal, L., Gill, A.L., Heathcote, M., Maman, S., Matthews, J.E., McMenamin, R.L., Navarro, E.F., O'Brien, M.A., O'Reilly, M., Rees, D.C., Reule, M., Tisi, D., Williams, G., Vinkovic, M., Wyatt, P.G.

(2009) J Med Chem 52: 379

Released2009-01-27
Method
X-RAY DIFFRACTION 2.6 Å
Organisms
Macromolecule
JAK2 (protein)
Unique LigandsL0I
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4CC5 | pdb_00004cc5

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Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase

Howard, S., Amin, N., Benowitz, A.B., Chiarparin, E., Cui, H., Deng, X., Heightman, T.D., Holmes, D.J., Hopkins, A., Huang, J., Jin, Q., Kreatsoulas, C., Martin, A.C.L., Massey, F., McCloskey, L., Mortenson, P.N., Pathuri, P., Tisi, D., Williams, P.A.

(2013) ACS Med Chem Lett 4: 1208

Released2014-06-18
Method
X-RAY DIFFRACTION 1.88 Å
Organisms
Macromolecule
DNA LIGASE (protein)
Unique LigandsL5V, SO4
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4CC6 | pdb_00004cc6

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Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase

Howard, S., Amin, N., Benowitz, A.B., Chiarparin, E., Cui, H., Deng, X., Heightman, T.D., Holmes, D.J., Hopkins, A., Huang, J., Jin, Q., Kreatsoulas, C., Martin, A.C.L., Massey, F., McCloskey, L., Mortenson, P.N., Pathuri, P., Tisi, D., Williams, P.A.

(2013) ACS Med Chem Lett 4: 1208

Released2014-06-18
Method
X-RAY DIFFRACTION 2.01 Å
Organisms
Macromolecule
DNA LIGASE (protein)
Unique LigandsL5Y, SO4
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5FPO | pdb_00005fpo

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Structure of Bacterial DNA Ligase with small-molecule ligand 1H- indazol-7-amine (AT4213) in an alternate binding site.

Jhoti, H., Ludlow, R.F., Pathuri, P., Saini, H.K., Tickle, I.J., Tisi, D., Verdonk, M., Williams, P.A.

(2015) Proc Natl Acad Sci U S A 112: 15910

Released2015-12-23
Method
X-RAY DIFFRACTION 1.83 Å
Organisms
Macromolecule
DNA LIGASE (protein)
Unique Ligands10L
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5FPR | pdb_00005fpr

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Structure of Bacterial DNA Ligase with small-molecule ligand pyrimidin-2-amine (AT371) in an alternate binding site.

Jhoti, H., Ludlow, R.F., Pathuri, P., Saini, H.K., Tickle, I.J., Tisi, D., Verdonk, M., Williams, P.A.

(2015) Proc Natl Acad Sci U S A 112: 15910

Released2015-12-16
Method
X-RAY DIFFRACTION 2 Å
Organisms
Macromolecule
DNA LIGASE (protein)
Unique LigandsLGA, SO4
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5LSS | pdb_00005lss

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Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives

Tisi, D., Pathuri, P.

(2016) ACS Chem Biol 11: 3093-3105

Released2016-10-05
Method
X-RAY DIFFRACTION 1.79 Å
Organisms
Macromolecule
Unique Ligands76H, SCN, ZN
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5LSU | pdb_00005lsu

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Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives

Tisi, D., Pathuri, P., Heightman, T.

(2016) ACS Chem Biol 11: 3093-3105

Released2016-10-05
Method
X-RAY DIFFRACTION 2.14 Å
Organisms
Macromolecule
Unique LigandsSAM, ZN
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5LSX | pdb_00005lsx

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Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives

Tisi, D., Pathuri, P., Heightman, T.

(2016) ACS Chem Biol 11: 3093-3105

Released2016-10-05
Method
X-RAY DIFFRACTION 2.9 Å
Organisms
Macromolecule
Unique Ligands76O, ZN
1 to 25 of 58 Structures
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