RCSB PDB: Search

1CGL \| pdb_00001cgl	Download File View File

Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor

Lovejoy, B., Cleasby, A., Hassell, A.M., Longley, K., Luther, M.A., Weigl, D., Mcgeehan, G., Mcelroy, A.B., Drewry, D., Lambert, M.H., Jordan, S.R.

(1994) Science 263: 375-377

Released	1995-02-27
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	FIBROBLAST COLLAGENASE (protein)
Unique Ligands	0ED, CA, ZN

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1F0J \| pdb_00001f0j	Download File View File

CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B

Xu, R.X., Hassell, A.M., Vanderwall, D., Lambert, M.H., Holmes, W.D., Luther, M.A., Rocque, W.J., Milburn, M.V., Zhao, Y., Ke, H., Nolte, R.T.

(2000) Science 288: 1822-1825

Released	2000-07-26
Method	X-RAY DIFFRACTION 1.77 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHODIESTERASE 4B (protein)
Unique Ligands	ARS, MG, ZN

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1FM6 \| pdb_00001fm6	Download File View File

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES.

Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliewer, S.A., Willson, T.M., Xu, H.E.

(2000) Mol Cell 5: 545-555

Released	2001-02-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (protein) RETINOIC ACID RECEPTOR RXR-ALPHA (protein) STEROID RECEPTOR COACTIVATOR (protein)
Unique Ligands	9CR, BRL

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1FM9 \| pdb_00001fm9	Download File View File

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.

Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliewer, S.A., Willson, T.M., Xu, H.E.

(2000) Mol Cell 5: 545-555

Released	2001-02-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (protein) RETINOIC ACID RECEPTOR RXR-ALPHA (protein) STEROID RECEPTOR COACTIVATOR (protein)
Unique Ligands	570, 9CR

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1G1U \| pdb_00001g1u	Download File View File

THE 2.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN IN TETRAMER IN THE ABSENCE OF LIGAND

Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Wisely, G.B., Milburn, M.V., Xu, H.E.

(2000) Genes Dev 14: 2229-2241

Released	2001-04-25
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	RETINOIC ACID RECEPTOR RXR-ALPHA (protein)

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1G5Y \| pdb_00001g5y	Download File View File

THE 2.0 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN TETRAMER IN THE PRESENCE OF A NON-ACTIVATING RETINOIC ACID ISOMER.

Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Wisely, G.B., Milburn, M.V., Xu, H.E.

(2000) Genes Dev 14: 2229-2241

Released	2001-05-02
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	RETINOIC ACID RECEPTOR RXR-ALPHA (protein)
Unique Ligands	REA

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1GWX \| pdb_00001gwx	Download File View File

MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS

Xu, H.E., Lambert, M.H., Montana, V.G., Park, D.J., Blanchard, S., Brown, P., Sternbach, D., Lehmann, J., Bruce, G.W., Willson, T.M., Kliewer, S.A., Milburn, M.V.

(1999) Mol Cell 3: 397-403

Released	2000-03-17
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (PPAR-DELTA) (protein)
Unique Ligands	433

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1K74 \| pdb_00001k74	Download File View File

The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.

Xu, H.E., Lambert, M.H., Montana, V.G., Moore, L.B., Collins, J.L., Oplinger, J.A., Kliewer, S.A., Gampe Jr., R.T., McKee, D.D., Moore, J.T., Willson, T.M.

(2001) Proc Natl Acad Sci U S A 98: 13919-13924

Released	2001-12-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Peroxisome proliferator activated receptor gamma (protein) Retinoic acid receptor RXR-alpha (protein) steroid receptor coactivator (protein)
Unique Ligands	544, 9CR

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1K7L \| pdb_00001k7l	Download File View File

The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.

Xu, H.E., Lambert, M.H., Montana, V.G., Moore, L.B., Collins, J.L., Oplinger, J.A., Kliewer, S.A., Gampe Jr., R.T., McKee, D.D., Moore, J.T., Willson, T.M.

(2001) Proc Natl Acad Sci U S A 98: 13919-13924

Released	2001-12-05
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Peroxisome proliferator activated receptor alpha (protein) steroid receptor coactivator (protein)
Unique Ligands	544, YT3

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1KKQ \| pdb_00001kkq	Download File View File

Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif

Xu, H.E., Stanley, T.B., Montana, V.G., Lambert, M.H., Shearer, B.G., Cobb, J.E., McKee, D.D., Galardi, C.M., Nolte, R.T., Parks, D.J.

(2002) Nature 415: 813-817

Released	2002-02-20
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	NUCLEAR RECEPTOR CO-REPRESSOR 2 (protein) PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (protein)
Unique Ligands	471

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1M13 \| pdb_00001m13	Download File View File

Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort

Watkins, R.E., Maglich, J.M., Moore, L.B., Wisely, G.B., Noble, S.M., Davis-Searles, P.R., Lambert, M.H., Kliewer, S.A., Redinbo, M.R.

(2003) Biochemistry 42: 1430-1438

Released	2003-03-04
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Orphan Nuclear Receptor PXR (protein)
Unique Ligands	HYF

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1M2Z \| pdb_00001m2z	Download File View File

Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif

Bledsoe, R.B., Montana, V.G., Stanley, T.B., Delves, C.J., Apolito, C.J., Mckee, D.D., Consler, T.G., Parks, D.J., Stewart, E.L., Willson, T.M., Lambert, M.H., Moore, J.T., Pearce, K.H., Xu, H.E.

(2002) Cell 110: 93-105

Released	2003-07-15
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	glucocorticoid receptor (protein) nuclear receptor coactivator 2 (protein)
Unique Ligands	BOG, DEX

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1NDE \| pdb_00001nde	Download File View File

Estrogen Receptor beta with Selective Triazine Modulator

Henke, B.R., Consler, T.G., Go, N., Hale, R.L., Hohman, D.R., Jones, S.A., Lu, A.T., Moore, L.B., Moore, J.T., Orband-Miller, L.A., Robinett, R.G., Shearin, J., Spearing, P.K., Stewart, E.L., Turnbull, P.S., Weaver, S.L., Williams, S.P., Wisely, G.B., Lambert, M.H.

(2002) J Med Chem 45: 5492-5505

Released	2002-12-18
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Estrogen receptor beta (protein)
Unique Ligands	MON

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1NRL \| pdb_00001nrl	Download File View File

Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813

Watkins, R.E., Davis-Searles, P.R., Lambert, M.H., Redinbo, M.R.

(2003) J Mol Biology 331: 815-828

Released	2003-08-19
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Nuclear Receptor Coactivator 1 isoform 3 (protein) Orphan nuclear receptor PXR (protein)
Unique Ligands	SRL

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1P8D \| pdb_00001p8d	Download File View File

X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol

Williams, S., Bledsoe, R.K., Collins, J.L., Boggs, S., Lambert, M.H., Miller, A.B., Moore, J., McKee, D.D., Moore, L., Nichols, J., Parks, D., Watson, M., Wisely, B., Willson, T.M.

(2003) J Biological Chem 278: 27138-27143

Released	2003-07-08
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Oxysterols receptor LXR-beta (protein) nuclear receptor coactivator 1 isoform 3 (protein)
Unique Ligands	CO1

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1PDU \| pdb_00001pdu	Download File View File

Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

Baker, K.D., Shewchuk, L.M., Korlova, T., Makishima, M., Hassell, A.M., Wisely, B., Caravella, J.A., Lambert, M.H., Wilson, T.M., Mangelsdorf, D.J.

(2003) Cell 113: 731-742

Released	2003-06-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Drosophila melanogaster
Macromolecule	nuclear hormone receptor HR38 (protein)

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1RO6 \| pdb_00001ro6	Download File View File

Crystal structure of PDE4B2B complexed with Rolipram (R & S)

Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.

(2004) J Mol Biology 337: 355-365

Released	2004-12-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (protein)
Unique Ligands	ARS, MN, ROL, ZN

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1RO9 \| pdb_00001ro9	Download File View File

CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP

Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.

(2004) J Mol Biology 337: 355-365

Released	2004-12-07
Method	X-RAY DIFFRACTION 2.13 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (protein)
Unique Ligands	8BR, ZN

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1ROR \| pdb_00001ror	Download File View File

CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP

Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.

(2004) J Mol Biology 337: 355-365

Released	2004-12-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (protein)
Unique Ligands	AMP, ZN

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1SQN \| pdb_00001sqn	Download File View File

Progesterone Receptor Ligand Binding Domain with bound Norethindrone

Williams, S.P., Madauss, K.P., Deng, J.-S., Austin, R.J.H., Lambert, M.H., McLay, I., Pritchard, J., Short, S.A., Stewart, E.L., Uings, I.J.

(2004) J Med Chem 47: 3381-3387

Released	2004-07-27
Method	X-RAY DIFFRACTION 1.451 Å
Organisms	Homo sapiens
Macromolecule	progesterone receptor (protein)
Unique Ligands	NDR

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1SR7 \| pdb_00001sr7	Download File View File

Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate

Madauss, K.P., Deng, S.-J., Austin, R.J., Lambert, M.H., McLay, I., Pritchard, J., Short, S.A., Stewart, E.L., Uings, I.J., Williams, S.P.

(2004) J Med Chem 47: 3381-3387

Released	2004-06-22
Method	X-RAY DIFFRACTION 1.46 Å
Organisms	Homo sapiens
Macromolecule	Progesterone receptor (protein)
Unique Ligands	GOL, MOF, SO4

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1XV9 \| pdb_00001xv9	Download File View File

crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione.

Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Moore, L.B., Willson, T.M., Moore, J.T.

(2004) Mol Cell 16: 919-928

Released	2004-12-28
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Orphan nuclear receptor NR1I3 (protein) Retinoic acid receptor RXR-alpha (protein) nuclear receptor coactivator 1 isoform 1 (protein)
Unique Ligands	CI2, F15

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1XVP \| pdb_00001xvp	Download File View File

crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO

Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Moore, L.B., Willson, T.M., Moore, J.T.

(2004) Mol Cell 16: 919-928

Released	2004-12-28
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Orphan nuclear receptor NR1I3 (protein) Retinoic acid receptor RXR-alpha (protein) nuclear receptor coactivator 1 isoform 1 (protein)
Unique Ligands	CID, F15

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1Y0S \| pdb_00001y0s	Download File View File

Crystal structure of PPAR delta complexed with GW2331

Takada, I., Yu, R.T., Xu, H.E., Xu, R.X., Lambert, M.H., Montana, V.G., Kliewer, S.A., Evans, R.M., Umesono, K.

(2000) Mol Endocrinol 14: 733-740

Released	2005-03-29
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Peroxisome proliferator activated receptor delta (protein)
Unique Ligands	331, B7G, IOD

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2AA2 \| pdb_00002aa2	Download File View File

Mineralocorticoid Receptor with Bound Aldosterone

Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.

(2005) J Biological Chem 280: 31283-31293

Released	2005-07-26
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Mineralocorticoid receptor (protein)
Unique Ligands	AS4, BOG, GOL, SO4

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1CGL | pdb_00001cgl

1F0J | pdb_00001f0j

1FM6 | pdb_00001fm6

1FM9 | pdb_00001fm9

1G1U | pdb_00001g1u

1G5Y | pdb_00001g5y

1GWX | pdb_00001gwx

1K74 | pdb_00001k74

1K7L | pdb_00001k7l

1KKQ | pdb_00001kkq

1M13 | pdb_00001m13

1M2Z | pdb_00001m2z

1NDE | pdb_00001nde

1NRL | pdb_00001nrl

1P8D | pdb_00001p8d

1PDU | pdb_00001pdu

1RO6 | pdb_00001ro6

1RO9 | pdb_00001ro9

1ROR | pdb_00001ror

1SQN | pdb_00001sqn

1SR7 | pdb_00001sr7

1XV9 | pdb_00001xv9

1XVP | pdb_00001xvp

1Y0S | pdb_00001y0s

2AA2 | pdb_00002aa2