RCSB PDB: Search

2CHW \| pdb_00002chw	Download File View File

A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39

Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.

(2006) Cell 125: 733

Released	2006-05-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (protein)
Unique Ligands	039

Explore in 3D

2CHX \| pdb_00002chx	Download File View File

A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90

Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.

(2006) Cell 125: 733

Released	2006-05-22
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (protein)
Unique Ligands	090

Explore in 3D

2CHZ \| pdb_00002chz	Download File View File

A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93

Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.

(2006) Cell 125: 733

Released	2006-05-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (protein)
Unique Ligands	093

Explore in 3D

2WXF \| pdb_00002wxf	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	039

Explore in 3D

2WXG \| pdb_00002wxg	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZN

Explore in 3D

2WXH \| pdb_00002wxh	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZO

Explore in 3D

2WXI \| pdb_00002wxi	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	GOL, S30

Explore in 3D

2WXJ \| pdb_00002wxj	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	RW3

Explore in 3D

2WXK \| pdb_00002wxk	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	RW4

Explore in 3D

2WXL \| pdb_00002wxl	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZS4

Explore in 3D

2WXM \| pdb_00002wxm	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZM

Explore in 3D

2WXN \| pdb_00002wxn	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	DLN

Explore in 3D

2WXO \| pdb_00002wxo	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZP

Explore in 3D

2WXP \| pdb_00002wxp	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	GD9

Explore in 3D

2WXQ \| pdb_00002wxq	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZQ

Explore in 3D

2WXR \| pdb_00002wxr	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)

Explore in 3D

2X38 \| pdb_00002x38	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-02-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	IC8

2CHW | pdb_00002chw

A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39

2CHX | pdb_00002chx

A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90

2CHZ | pdb_00002chz

A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93

2WXF | pdb_00002wxf

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39.

2WXG | pdb_00002wxg

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13.

2WXH | pdb_00002wxh

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14.

2WXI | pdb_00002wxi

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30.

2WXJ | pdb_00002wxj

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654.

2WXK | pdb_00002wxk

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666.

2WXL | pdb_00002wxl

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474.

2WXM | pdb_00002wxm

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06.

2WXN | pdb_00002wxn

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07.

2WXO | pdb_00002wxo

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5.

2WXP | pdb_00002wxp

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941.

2WXQ | pdb_00002wxq

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15.

2WXR | pdb_00002wxr

The crystal structure of the murine class IA PI 3-kinase p110delta.

2X38 | pdb_00002x38

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.

Prepare Data

Validate Data

Deposit Data

Help and Resources

Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2CHW | pdb_00002chw

2CHX | pdb_00002chx

2CHZ | pdb_00002chz

2WXF | pdb_00002wxf

2WXG | pdb_00002wxg

2WXH | pdb_00002wxh

2WXI | pdb_00002wxi

2WXJ | pdb_00002wxj

2WXK | pdb_00002wxk

2WXL | pdb_00002wxl

2WXM | pdb_00002wxm

2WXN | pdb_00002wxn

2WXO | pdb_00002wxo

2WXP | pdb_00002wxp

2WXQ | pdb_00002wxq

2WXR | pdb_00002wxr

2X38 | pdb_00002x38