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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Wong, L."

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Search Summary

This query matches 51 Structures.

Refinements

Structure Determination Methodology

experimental (51)

Scientific Name of Source Organism

	Human immunodeficiency virus type 1 BH10 (28)
	Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1)) (11)
	Human immunodeficiency virus 1 (8)
	Influenza A virus (A/Luxembourg/43/2009(H1N1)) (2)
	Homo sapiens (1)
	Influenza A virus (A/California/02/2010(H1N1)) (1)
	Influenza A virus (A/duck/Hokkaido/8/1980(H3N8)) (1)
	Parengyodontium album (1)

Taxonomy

	Riboviria (49)
	Eukaryota (2)

Experimental Method

X-RAY DIFFRACTION (51)

Polymer Entity Type

Protein (51)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (25)
	2.0 - 2.5 (17)
	2.5 - 3.0 (6)
	3.0 - 3.5 (1)

Release Date

	2005 - 2009 (4)
	2010 - 2014 (27)
	2015 - 2019 (8)
	2020 - 2024 (12)

Enzyme Classification Name

	Transferases (33)
	Hydrolases (36)

Symmetry Type

	Asymmetric (50)
	Cyclic (11)

SCOP Classification

	Multi-domain proteins (alpha and beta) (20)
	Alpha and beta proteins (a/b) (38)
	Artifacts (34)

AllSelected

1 to 25 of 51 Structures

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2ZD1 \| pdb_00002zd1	Download File View File

Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor

Das, K., Bauman, J.D., Clark Jr., A.D., Shatkin, A.J., Arnold, E.

(2008) Proc Natl Acad Sci U S A 105: 1466-1471

Released	2008-02-12
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	Reverse transcriptase/ribonuclease H (protein) p51 RT (protein)
Unique Ligands	EDO, SO4, T27

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2ZE2 \| pdb_00002ze2	Download File View File

Crystal structure of L100I/K103N mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (rilpivirine), a non-nucleoside RT inhibitor

Das, K., Bauman, J.D., Clark Jr., A.D., Shatkin, A.J., Arnold, E.

(2008) Proc Natl Acad Sci U S A 105: 1466-1471

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	Reverse transcriptase/ribonuclease H (protein) p51 RT (protein)
Unique Ligands	T27

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3BGR \| pdb_00003bgr	Download File View File

Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor

Das, K., Bauman, J.D., Clark Jr., A.D., Shatkin, A.J., Arnold, E.

(2008) Proc Natl Acad Sci U S A 105: 1466-1471

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	Reverse transcriptase/ribonuclease H (protein) p51 RT (protein)
Unique Ligands	EDO, T27

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3DLK \| pdb_00003dlk	Download File View File

Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A

Ho, W.C., Bauman, J.D., Himmel, D.M., Das, K., Arnold, E.

(2008) Nucleic Acids Res 36: 5083-5092

Released	2008-10-07
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	Reverse transcriptase/ribonuclease H (protein) p51 RT (protein)
Unique Ligands	SO4

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3IS9 \| pdb_00003is9	Download File View File

Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).

Ho, W.C., Bauman, J.D., Das, K., Arnold, E.

(2009) J Med Chem 52: 6467-6473

Released	2010-04-07
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	Reverse transcriptase (protein) Reverse transcriptase/ribonuclease H (protein)
Unique Ligands	AC7

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3QLH \| pdb_00003qlh	Download File View File

HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket

Himmel, D.M., Wojtak, K., Bauman, J.D., Arnold, E.

(2011) J Med Chem 54: 4462-4473

Released	2011-12-21
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	reverse transcriptase/ribonuclease H (protein)
Unique Ligands	DMS, EDO, MN, MNK, T27

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3S24 \| pdb_00003s24	Download File View File

Crystal structure of human mRNA guanylyltransferase

Das, K., Chu, C., Thyminski, J.R., Bauman, J.D., Guan, R., Qiu, W., Montelione, G.T., Arnold, E., Shatkin, A.J.

(2011) Proc Natl Acad Sci U S A 108: 10104-10108

Released	2011-06-15
Method	X-RAY DIFFRACTION 3.0137 Å
Organisms	Homo sapiens
Macromolecule	mRNA-capping enzyme (protein)
Unique Ligands	SO4

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4G1Q \| pdb_00004g1q	Download File View File

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug

Bauman, J.D., Patel, D., Das, K., Arnold, E.

(2013) Nat Chem 5: 174-181

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.51 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	Reverse transcriptase/ribonuclease H (protein) p51 RT (protein)
Unique Ligands	EDO, MG, SO4, T27

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4I2P \| pdb_00004i2p	Download File View File

Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) based analogue

Patel, D., Bauman, J.D., Das, K., Arnold, E.

(2012) Retrovirology 9: 99-99

Released	2013-01-16
Method	X-RAY DIFFRACTION 2.2964 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	Gag-Pol polyprotein (protein)
Unique Ligands	G73

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4I2Q \| pdb_00004i2q	Download File View File

Crystal structure of K103N/Y181C mutant of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) analogue

Patel, D., Bauman, J.D., Das, K., Arnold, E.

(2012) Retrovirology 9: 99-99

Released	2013-01-16
Method	X-RAY DIFFRACTION 2.7004 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	Gag-Pol polyprotein (protein)
Unique Ligands	1BT, EDO

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4ICL \| pdb_00004icl	Download File View File

HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site

Bauman, J.D., Patel, D., Arnold, E.

(2013) J Med Chem 56: 2738-2746

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	Reverse transcriptase/ribonuclease H (protein) p51 RT (protein)
Unique Ligands	14N, DMS, MG, T27

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4ID5 \| pdb_00004id5	Download File View File

HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site

Bauman, J.D., Patel, D., Arnold, E.

(2013) J Med Chem 56: 2738-2746

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	P51 RT (protein) Reverse transcriptase/ribonuclease H (protein)
Unique Ligands	1FF, DMS, MG, T27

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4IDK \| pdb_00004idk	Download File View File

HIV-1 reverse transcriptase with bound fragment at the 428 site

Bauman, J.D., Patel, D., Arnold, E.

(2013) J Med Chem 56: 2738-2746

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	Reverse transcriptase/ribonuclease H (protein) p51 RT (protein)
Unique Ligands	1FE, DMS, MG, T27

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4IFV \| pdb_00004ifv	Download File View File

Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening

Bauman, J.D., Patel, D., Fromer, M., Arnold, E.

(2013) J Med Chem 56: 2738-2746

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	Exoribonuclease H, p66 RT (protein) Gag-Pol polyprotein (protein)
Unique Ligands	DMS, FMQ, MG, T27

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4IFY \| pdb_00004ify	Download File View File

HIV-1 reverse transcriptase with bound fragment at the Knuckles site

Bauman, J.D., Patel, D., Arnold, E.

(2013) J Med Chem 56: 2738-2746

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	REVERSE TRANSCRIPTASE/RIBONUCLEASE H (protein) p51 RT (protein)
Unique Ligands	1FD, DMS, MG, T27

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4IG0 \| pdb_00004ig0	Download File View File

HIV-1 reverse transcriptase with bound fragment at the 507 site

Bauman, J.D., Patel, D., Arnold, E.

(2013) J Med Chem 56: 2738-2746

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	P51 RT (protein) Reverse transcriptase/ribonuclease H (protein)
Unique Ligands	1FG, DMS

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4IG3 \| pdb_00004ig3	Download File View File

HIV-1 reverse transcriptase with bound fragment near Knuckles site

Bauman, J.D., Patel, D., Arnold, E.

(2013) J Med Chem 56: 2738-2746

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	P51 RT (protein) Reverse transcriptase/ribonuclease H (protein)
Unique Ligands	DMS, J94, T27

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4KFB \| pdb_00004kfb	Download File View File

HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site

Bauman, J.D., Patel, D., Arnold, E.

(2013) J Med Chem 56: 2738

Released	2013-05-15
Method	X-RAY DIFFRACTION 1.854 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	P51 RT (protein) REVERSE TRANSCRIPTASE/RIBONUCLEASE H, EXORIBONUCLEA P66 RT (protein)
Unique Ligands	1QP, DMS, T27

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4KIL \| pdb_00004kil	Download File View File

7-(4-fluorophenyl)-3-hydroxyquinolin-2(1H)-one bound to influenza 2009 H1N1 endonuclease

Bauman, J.D., Patel, D., Das, K., Arnold, E.

(2013) ACS Med Chem Lett 4: 547-550

Released	2013-05-29
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
Macromolecule	Polymerase PA (protein)
Unique Ligands	1R5, EDO, MN, SO4

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4KO0 \| pdb_00004ko0	Download File View File

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH an anilinylpyrimidine derivative (JLJ-135)

Das, K., Bauman, J.D., Arnold, E.

(2013) Bioorg Med Chem Lett 23: 5209-5212

Released	2013-08-14
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Human immunodeficiency virus type 1 BH10
Macromolecule	HIV-1 reverse transcriptase, p51 subunit (protein) HIV-1 reverse transcriptase, p66 subunit (protein)
Unique Ligands	EDO, JLJ, SO4

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4LN7 \| pdb_00004ln7	Download File View File

5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease

Bauman, J.D., Patel, D., Das, K., Arnold, E.

(2013) ACS Chem Biol 8: 2501-2508

Released	2013-09-18
Method	X-RAY DIFFRACTION 1.73 Å
Organisms	Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
Macromolecule	POLYMERASE PA (protein)
Unique Ligands	1ZQ, EDO, MG, MN, SO4

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4M4Q \| pdb_00004m4q	Download File View File

6-(4-fluorophenyl)-3-hydroxy-5-[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl] -1,2-dihydropyridin-2-one bound to influenza 2009 H1N1 endonuclease

Bauman, J.D., Patel, D., Das, K., Arnold, E.

(2013) ACS Chem Biol 8: 2501-2508

Released	2013-09-18
Method	X-RAY DIFFRACTION 2.502 Å
Organisms	Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
Macromolecule	Polymerase PA (protein)
Unique Ligands	21A, MG, MN, SO4

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4M5O \| pdb_00004m5o	Download File View File

3-HYDROXY-6-PHENYL-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 H1N1 endonuclease

Bauman, J.D., Patel, D., Das, K., Arnold, E.

(2013) ACS Chem Biol 8: 2501-2508

Released	2013-09-18
Method	X-RAY DIFFRACTION 2 Å
Organisms	Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
Macromolecule	Polymerase PA (protein)
Unique Ligands	EDO, MN, SO4, X48

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4M5Q \| pdb_00004m5q	Download File View File

High-resolution apo influenza 2009 H1N1 endonuclease structure

Bauman, J.D., Patel, D., Das, K., Arnold, E.

(2013) ACS Chem Biol 8: 2501-2508

Released	2013-09-18
Method	X-RAY DIFFRACTION 1.534 Å
Organisms	Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
Macromolecule	Polymerase PA (protein)
Unique Ligands	EDO, MN

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4M5R \| pdb_00004m5r	Download File View File

High-resolution influenza 2009 H1N1 endonuclease bound to 4-(1H-IMIDAZOL-1-YL)PHENOL

Bauman, J.D., Patel, D., Das, K., Arnold, E.

(2013) ACS Chem Biol 8: 2501-2508

Released	2013-09-18
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
Macromolecule	Polymerase PA (protein)
Unique Ligands	EDO, MN, MSR, SO4

1 to 25 of 51 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2ZD1 | pdb_00002zd1

2ZE2 | pdb_00002ze2

3BGR | pdb_00003bgr

3DLK | pdb_00003dlk

3IS9 | pdb_00003is9

3QLH | pdb_00003qlh

3S24 | pdb_00003s24

4G1Q | pdb_00004g1q

4I2P | pdb_00004i2p

4I2Q | pdb_00004i2q

4ICL | pdb_00004icl

4ID5 | pdb_00004id5

4IDK | pdb_00004idk

4IFV | pdb_00004ifv

4IFY | pdb_00004ify

4IG0 | pdb_00004ig0

4IG3 | pdb_00004ig3

4KFB | pdb_00004kfb

4KIL | pdb_00004kil

4KO0 | pdb_00004ko0

4LN7 | pdb_00004ln7

4M4Q | pdb_00004m4q

4M5O | pdb_00004m5o

4M5Q | pdb_00004m5q

4M5R | pdb_00004m5r