RCSB PDB: Search

2I7N \| pdb_00002i7n	Download File View File

Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA

Hong, B.S., Wang, L., Tempel, W., Loppnau, P., Allali-Hassani, A., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W.

(2007) J Biological Chem 282: 27984-27993

Released	2006-12-26
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Pantothenate kinase 1 (protein)
Unique Ligands	ACO

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2I7P \| pdb_00002i7p	Download File View File

Crystal structure of human PANK3 in complex with AcCoA

Hong, B.S., Wang, L., Shen, L., Tempel, W., Loppnau, P., Finerty, P., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)

(2007) J Biological Chem 282: 27984-27993

Released	2006-12-26
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Pantothenate kinase 3 (protein)
Unique Ligands	ACO

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2ONU \| pdb_00002onu	Download File View File

Plasmodium falciparum ubiquitin conjugating enzyme PF10_0330, putative homologue of human UBE2H

Dong, A., Lew, J., Lin, L., Hassanali, A., Zhao, Y., Senisterra, G., Wasney, G., Vedadi, M., Kozieradzki, I., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Hui, R., Brokx, S.J., Structural Genomics Consortium (SGC)

To be published

Released	2007-02-06
Method	X-RAY DIFFRACTION 2.38 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Ubiquitin-conjugating enzyme, putative (protein)
Unique Ligands	PG4

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2P0K \| pdb_00002p0k	Download File View File

Crystal structure of SCMH1

Herzanych, N., Senisterra, G., Liu, Y., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)

To be published

Released	2007-03-27
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Polycomb protein SCMH1 (protein)
Unique Ligands	CL, PO4

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2QG7 \| pdb_00002qg7	Download File View File

Plasmodium vivax ethanolamine kinase Pv091845

Lunin, V.V., Wernimont, A.K., Mulichak, A., Lew, J., Wasney, G., Senisterra, G., Kozieradzki, I., Vedadi, M., Bochkarev, A., Arrowsmith, C.H., Sundstrom, M., Weigelt, J., Edwards, A.E., Hui, R., Hills, T., Artz, J., Xiao, T., Structural Genomics Consortium (SGC)

To be published

Released	2007-07-24
Method	X-RAY DIFFRACTION 2.407 Å
Organisms	Plasmodium vivax
Macromolecule	ethanolamine kinase Pv091845 (protein)
Unique Ligands	SO4

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2QNR \| pdb_00002qnr	Download File View File

Human septin 2 in complex with GDP

Rabeh, W.M., Nedyalkova, L., Tempel, W., Landry, R., Crombet, L., Kozieradzki, I., Senisterra, G., Vedadi, M., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)

To be published

Released	2007-07-31
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Septin-2 (protein)
Unique Ligands	GDP, UNX

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2WEI \| pdb_00002wei	Download File View File

Crystal structure of the kinase domain of Cryptosporidium parvum calcium dependent protein kinase in complex with 3-MB-PP1

Roos, A.K., King, O., Chaikuad, A., Zhang, C., Shokat, K.M., Wernimont, A.K., Artz, J.D., Lin, L., MacKenzie, F.I., Finerty, P.J., Vedadi, M., Schapira, M., Indarte, M., Kozieradzki, I., Pike, A.C.W., Fedorov, O., Doyle, D., Muniz, J., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., von Delft, F., Heightman, T., Hui, R.

(2011) BMC Genomics 12: 478

Released	2009-04-28
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Cryptosporidium parvum Iowa II
Macromolecule	CALMODULIN-DOMAIN PROTEIN KINASE 1, PUTATIVE (protein)
Unique Ligands	VGG

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3C5I \| pdb_00003c5i	Download File View File

Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520

Wernimont, A.K., Hills, T., Lew, J., Wasney, G., Senesterra, G., Kozieradzki, I., Cossar, D., Vedadi, M., Schapira, M., Bochkarev, A., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Hui, R., Artz, J.D., Xiao, T., Structural Genomics Consortium (SGC)

To be published

Released	2008-02-19
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Plasmodium knowlesi
Macromolecule	Choline kinase (protein) Cleaved fragment of N-terminal expression tag (protein)
Unique Ligands	CA, CHT, GOL, MG, UNL

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3HX4 \| pdb_00003hx4	Download File View File

Crystal structure of CDPK1 of Toxoplasma gondii, TGME49_101440, in presence of calcium

Wernimont, A.K., Artz, J.D., Finnerty, P., Xiao, T., He, H., MacKenzie, F., Sinestera, G., Hassani, A.A., Wasney, G., Vedadi, M., Lourido, S., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Sibley, D.L., Hui, R., Lin, Y.H., Structural Genomics Consortium (SGC)

(2010) Nat Struct Mol Biol 17: 596-601

Released	2009-07-21
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Toxoplasma gondii
Macromolecule	Calmodulin-domain protein kinase 1 (protein)
Unique Ligands	ANP, CA, GOL, SO4

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3HZT \| pdb_00003hzt	Download File View File

Crystal structure of Toxoplasma gondii CDPK3, TGME49_105860

Wernimont, A.K., Artz, J.D., Finnerty, P., Wasney, G., Allali-Hassani, A., Vedadi, M., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Hui, R., Amani, M., Structural Genomics Consortium (SGC)

(2010) Nat Struct Mol Biol 17: 596-601

Released	2009-07-21
Method	X-RAY DIFFRACTION 2 Å
Organisms	Toxoplasma gondii ME49
Macromolecule	Calcium-dependent protein kinase 3 (protein)
Unique Ligands	GOL, J60, MG

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3IGO \| pdb_00003igo	Download File View File

Crystal structure of Cryptosporidium parvum CDPK1, cgd3_920

Wernimont, A.K., Artz, J.D., Finnerty, P., Amani, M., Allali-Hassanali, A., Vedadi, M., Tempel, W., MacKenzie, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Bochkarev, A., Hui, R., Lin, Y.H., Structural Genomics Consortium (SGC)

(2010) Nat Struct Mol Biol 17: 596-601

Released	2009-08-11
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Cryptosporidium parvum Iowa II
Macromolecule	Calmodulin-domain protein kinase 1 (protein)
Unique Ligands	ANP, CA, GOL, PO4, SRT

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3IS5 \| pdb_00003is5	Download File View File

Crystal structure of CDPK kinase domain from toxoplasma Gondii, TGME49_018720

Wernimont, A.K., Artz, J.D., Senisterra, G., MacKenzie, F., Hutchinson, A., Kozieradzki, I., Cossar, D., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Hui, R., Lin, Y.H., Structural Genomics Consortium (SGC)

To be published

Released	2009-10-20
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Toxoplasma gondii ME49
Macromolecule	Calcium-dependent protein kinase (protein)
Unique Ligands	ANP, CA, GOL, MG

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3JWP \| pdb_00003jwp	Download File View File

Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP

Wernimont, A.K., Hutchinson, A., Lin, Y.H., MacKenzie, F., Senisterra, G., Allali-Hassanali, A., Vedadi, M., Ravichandran, M., Cossar, D., Kozieradzki, I., Zhao, Y., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Hui, R., Qiu, W., Brand, V., Structural Genomics Consortium (SGC)

To be published

Released	2009-10-20
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Transcriptional regulatory protein sir2 homologue (protein)
Unique Ligands	AMP, PGE, ZN

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3K5K \| pdb_00003k5k	Download File View File

Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a

Dong, A., Wasney, G.A., Liu, F., Chen, X., Allali-Hassani, A., Senisterra, G., Chau, I., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Frye, S.V., Bochkarev, A., Brown, P.J., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)

(2009) J Med Chem 52: 7950-7953

Released	2009-11-10
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (protein)
Unique Ligands	CL, DXQ, SAH, UNX, ZN

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3KU2 \| pdb_00003ku2	Download File View File

Crystal Structure of inactivated form of CDPK1 from toxoplasma gondii, TGME49.101440

Wernimont, A.K., Artz, J.D., Finnerty, P., Xiao, T., He, H., Mackenzie, F., Sinestera, G., Hassani, A.A., Wasney, G., Vedadi, M., Lourido, S., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Sibley, D.L., Hui, R., Lin, Y.H., Structural Genomics Consortium (SGC)

(2010) Nat Struct Mol Biol 17: 596-601

Released	2010-02-16
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Toxoplasma gondii
Macromolecule	Calmodulin-domain protein kinase 1 (protein)
Unique Ligands	ANP, UNX

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3L19 \| pdb_00003l19	Download File View File

Crystal structure of calcium binding domain of CpCDPK3, cgd5_820

Qiu, W., Hutchinson, A., Wernimont, A., Walker, J.R., Sullivan, H., Lin, Y.-H., Mackenzie, F., Kozieradzki, I., Cossar, D., Schapira, M., Senisterra, G., Vedadi, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Bochkarev, A., Hui, R., Amani, M., Structural Genomics Consortium (SGC)

To be published

Released	2009-12-22
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Cryptosporidium parvum Iowa II
Macromolecule	Calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands (protein)
Unique Ligands	1PE, CA, GOL

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3LIJ \| pdb_00003lij	Download File View File

Crystal structure of full length CpCDPK3 (cgd5_820) in complex with Ca2+ and AMPPNP

Qiu, W., Hutchinson, A., Wernimont, A., Walker, J.R., Sullivan, H., Lin, Y.-H., Mackenzie, F., Kozieradzki, I., Cossar, D., Schapira, M., Senisterra, G., Vedadi, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Bochkarev, A., Hui, R., Amani, M., Structural Genomics Consortium (SGC)

To be published

Released	2010-02-02
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Cryptosporidium parvum Iowa II
Macromolecule	Calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands (protein)
Unique Ligands	ANP, CA, MG

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3MA6 \| pdb_00003ma6	Download File View File

Crystal structure of kinase domain of TgCDPK1 in presence of 3BrB-PP1

Wernimont, A.K., Qiu, W., Amani, M., Artz, J.D., Hassani, A.A., Senisterra, G., Vedadi, M., Sibley, L.D., Lourido, S., Shokat, K., Zhang, C., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Hui, R., Lin, Y.H., Structural Genomics Consortium (SGC)

To be published

Released	2010-07-21
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Toxoplasma gondii
Macromolecule	Calmodulin-domain protein kinase 1 (protein)
Unique Ligands	DXR

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3N9X \| pdb_00003n9x	Download File View File

Crystal structure of Map Kinase from plasmodium berghei, PB000659.00.0

Wernimont, A.K., Hutchinson, A., Sullivan, H., MacKenzie, F., Kozieradzki, I., Chau, I., Lew, J., Senisterra, G., Artz, J., Amani, M., Cossar, D., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Hui, R., Hills, T., Structural Genomics Consortium (SGC)

To be published

Released	2010-07-28
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Plasmodium berghei
Macromolecule	Phosphotransferase (protein)
Unique Ligands	GOL

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3NIE \| pdb_00003nie	Download File View File

Crystal Structure of PF11_0147

Wernimont, A.K., Hutchinson, A., Sullivan, H., MacKenzie, F., Kozieradzki, I., Chau, I., Lew, J., Senisterra, G., Cossar, D., Amani, M., Artz, J.D., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Hui, R., Hills, T., Structural Genomics Consortium (SGC)

To be published

Released	2010-08-11
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Plasmodium falciparum
Macromolecule	MAP2 kinase (protein)
Unique Ligands	ANP

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3O6O \| pdb_00003o6o	Download File View File

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021

Wernimont, A.K., Hutchinson, A., Sullivan, H., Weadge, J., Li, Y., Kozieradzki, I., Cossar, D., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Wyatt, P., Fairlamb, A.H., Ferguson, M.A.J., Thompson, S., MacKenzie, C., Hui, R., Pizarro, J.C., Hills, T., Structural Genomics Consortium (SGC)

(2013) PLoS Negl Trop Dis 7: e2492-e2492

Released	2010-08-18
Method	X-RAY DIFFRACTION 2 Å
Organisms	Trypanosoma brucei
Macromolecule	Heat shock protein 83 (protein)
Unique Ligands	1PE, 94M

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3OMU \| pdb_00003omu	Download File View File

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative

Wernimont, A.K., Hutchinson, A., Sullivan, H., Weadge, J., Cossar, D., Li, Y., Kozieradzki, I., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Wyatt, P.G., Fairlamb, A.H., MacKenzie, C., Ferguson, M.A.J., Hui, R., Pizarro, J.C., Hills, T., Structural Genomics Consortium (SGC)

(2013) PLoS Negl Trop Dis 7: e2492-e2492

Released	2010-10-27
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Trypanosoma brucei
Macromolecule	Heat shock protein 83 (protein)
Unique Ligands	IBD

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3OPD \| pdb_00003opd	Download File View File

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a benzamide derivative

Pizarro, J.C., Wernimont, A.K., Hutchinson, A., Sullivan, H., Chamberlain, K., Weadge, J., Cossar, D., Li, Y., Kozieradzki, I., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Wyatt, P.G., Fairlamb, A.H., MacKenzie, C., Ferguson, M.A.J., Hui, R., Hills, T., Structural Genomics Consortium (SGC)

(2013) PLoS Negl Trop Dis 7: e2492-e2492

Released	2010-10-13
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Trypanosoma brucei brucei
Macromolecule	Heat shock protein 83 (protein)
Unique Ligands	HIE

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3P8H \| pdb_00003p8h	Download File View File

Crystal structure of L3MBTL1 (MBT repeat) in complex with a nicotinamide antagonist

Lam, R., Herold, J.M., Ouyang, H., Tempel, W., Gao, C., Ravichandran, M., Senisterra, G., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Kireev, D., Frye, S.V., Brown, P.J., Structural Genomics Consortium (SGC)

(2011) J Med Chem 54: 2504-2511

Released	2010-11-03
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Lethal(3)malignant brain tumor-like protein (protein)
Unique Ligands	GOL, P8H, SO4

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3PEH \| pdb_00003peh	Download File View File

Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative

Wernimont, A.K., Tempel, W., Hutchinson, A., Weadge, J., Cossar, D., MacKenzie, F., Vedadi, M., Senisterra, G., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Wyatt, P.G., Fairlamb, A.H., MacKenzie, C., Ferguson, M.A.J., Hui, R., Pizarro, J.C., Hills, T., Structural Genomics Consortium (SGC)

To be published

Released	2010-11-17
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Endoplasmin homolog (protein)
Unique Ligands	IBD, SO4

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2I7N | pdb_00002i7n

2I7P | pdb_00002i7p

2ONU | pdb_00002onu

2P0K | pdb_00002p0k

2QG7 | pdb_00002qg7

2QNR | pdb_00002qnr

2WEI | pdb_00002wei

3C5I | pdb_00003c5i

3HX4 | pdb_00003hx4

3HZT | pdb_00003hzt

3IGO | pdb_00003igo

3IS5 | pdb_00003is5

3JWP | pdb_00003jwp

3K5K | pdb_00003k5k

3KU2 | pdb_00003ku2

3L19 | pdb_00003l19

3LIJ | pdb_00003lij

3MA6 | pdb_00003ma6

3N9X | pdb_00003n9x

3NIE | pdb_00003nie

3O6O | pdb_00003o6o

3OMU | pdb_00003omu

3OPD | pdb_00003opd

3P8H | pdb_00003p8h

3PEH | pdb_00003peh