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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Spevak, W."

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Search Summary

This query matches 17 Structures.

Refinements

Structure Determination Methodology

experimental (17)

Scientific Name of Source Organism

Homo sapiens (17)

Taxonomy

Eukaryota (17)

Experimental Method

X-RAY DIFFRACTION (17)

Polymer Entity Type

Protein (17)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (2)
	2.0 - 2.5 (7)
	2.5 - 3.0 (4)
	3.0 - 3.5 (1)

Release Date

	2000 - 2004 (1)
	2010 - 2014 (3)
	2015 - 2019 (10)
	2020 - 2024 (3)

Enzyme Classification Name

	Transferases (13)
	Hydrolases (1)

Symmetry Type

	Asymmetric (12)
	Cyclic (7)

SCOP Classification

	Alpha and beta proteins (a+b) (11)
	Artifacts (9)
	All alpha proteins (3)

AllSelected

1 to 17 of 17 Structures

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1JQH \| pdb_00001jqh	Download File View File

IGF-1 receptor kinase domain

Pautsch, A., Zoephel, A., Ahorn, H., Spevak, W., Hauptmann, R., Nar, H.

(2001) Structure 9: 955-965

Released	2002-04-19
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	IGF-1 receptor kinase (protein)
Unique Ligands	ANP, MG, SO4

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3OG7 \| pdb_00003og7	Download File View File

B-Raf Kinase V600E oncogenic mutant in complex with PLX4032

Zhang, Y., Zhang, K.Y., Zhang, C.

(2010) Nature 467: 596-599

Released	2010-09-22
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens
Macromolecule	AKAP9-BRAF fusion protein (protein)
Unique Ligands	032

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4HVS \| pdb_00004hvs	Download File View File

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647

Zhang, Y., Zhang, C.

(2013) Proc Natl Acad Sci U S A 110: 5689-5694

Released	2013-03-27
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Mast/stem cell growth factor receptor Kit (protein)
Unique Ligands	647

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4HW7 \| pdb_00004hw7	Download File View File

Crystal structure of FMS kinase domain with a small molecular inhibitor, PLX647-OME

Zhang, Y., Zhang, C.

(2013) Proc Natl Acad Sci U S A 110: 5689-5694

Released	2013-03-27
Method	X-RAY DIFFRACTION 2.9001 Å
Organisms	Homo sapiens
Macromolecule	Macrophage colony-stimulating factor 1 receptor (protein)
Unique Ligands	64M

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4RT7 \| pdb_00004rt7	Download File View File

Crystal Structure of FLT3 with a small molecule inhibitor

Zhang, Y., Zhang, C.

(2015) Cancer Discov 5: 668-679

Released	2015-04-22
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Receptor-type tyrosine-protein kinase FLT3 (protein)
Unique Ligands	P30

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4XV1 \| pdb_00004xv1	Download File View File

B-Raf Kinase V600E oncogenic mutant in complex with PLX7904

Zhang, Y., Zhang, C.

(2015) Nature 526: 583-586

Released	2015-10-28
Method	X-RAY DIFFRACTION 2.47 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	904

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4XV2 \| pdb_00004xv2	Download File View File

B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib

zhang, Y., zhang, c.

(2015) Nature 526: 583-586

Released	2015-10-28
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	P06

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4XV3 \| pdb_00004xv3	Download File View File

B-Raf Kinase V600E oncogenic mutant in complex with PLX7922

Zhang, Y., Zhang, C.

(2015) Nature 526: 583-586

Released	2015-10-28
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	P02

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4XV9 \| pdb_00004xv9	Download File View File

B-Raf Kinase domain in complex with PLX5568

zhang, Y., zhang, c., wang, w.

(2015) Nature 526: 583-586

Released	2015-10-28
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	1OO, SO4

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5TXK \| pdb_00005txk	Download File View File

CRYSTAL STRUCTURE OF USP35 C450S IN COMPLEX WITH UBIQUITIN

Bader, G., Weiss-Puxbaum, A., Zoephel, A.

(2018) J Cell Sci 131:

Released	2018-05-09
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Homo sapiens
Macromolecule	Polyubiquitin-B (protein) Ubiquitin carboxyl-terminal hydrolase 35,Ubiquitin carboxyl-terminal hydrolase 35 (protein)
Unique Ligands	EDO, SO4, ZN

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5WMA \| pdb_00005wma	Download File View File

N-terminal bromodomain of BRD4 in complex with PLX5981

Zhang, Y.

(2018) Cancer Discov 8: 458-477

Released	2018-08-01
Method	X-RAY DIFFRACTION 1.401 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	6JC, EDO

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5WMD \| pdb_00005wmd	Download File View File

N-terminal bromodomain of BRD4 in complex with OTX-015

Zhang, Y.

(2018) Cancer Discov 8: 458-477

Released	2018-08-01
Method	X-RAY DIFFRACTION 1.27 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	6JE

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5WMG \| pdb_00005wmg	Download File View File

N-terminal bromodomain of BRD4 in complex with OTX-015

Zhang, Y.

(2018) Cancer Discov 8: 458-477

Released	2018-08-01
Method	X-RAY DIFFRACTION 1.19 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	6JF, EDO

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6N33 \| pdb_00006n33	Download File View File

Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622

Zhang, Y.

(2019) Nat Commun 10: 3758-3758

Released	2019-09-18
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Macrophage colony-stimulating factor 1 receptor (protein)
Unique Ligands	622

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7KHG \| pdb_00007khg	Download File View File

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX3397

Zhang, Y.

(2021) JAMA Oncol 7: 1343-1350

Released	2021-07-07
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Mast/stem cell growth factor receptor Kit (protein)
Unique Ligands	P31

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7KHJ \| pdb_00007khj	Download File View File

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX8512 in the DFG-in state

Zhang, Y.

(2021) JAMA Oncol 7: 1343-1350

Released	2021-07-07
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Mast/stem cell growth factor receptor Kit (protein)
Unique Ligands	WEG

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7KHK \| pdb_00007khk	Download File View File

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX9486 (bezuclastinib) in the DFG-in state

Zhang, Y.

(2021) JAMA Oncol 7: 1343-1350

Released	2021-07-07
Method	X-RAY DIFFRACTION 2.34 Å
Organisms	Homo sapiens
Macromolecule	Mast/stem cell growth factor receptor Kit (protein)
Unique Ligands	WEJ

1 to 17 of 17 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1JQH | pdb_00001jqh

IGF-1 receptor kinase domain

3OG7 | pdb_00003og7

B-Raf Kinase V600E oncogenic mutant in complex with PLX4032

4HVS | pdb_00004hvs

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647

4HW7 | pdb_00004hw7

Crystal structure of FMS kinase domain with a small molecular inhibitor, PLX647-OME

4RT7 | pdb_00004rt7

Crystal Structure of FLT3 with a small molecule inhibitor

4XV1 | pdb_00004xv1

B-Raf Kinase V600E oncogenic mutant in complex with PLX7904

4XV2 | pdb_00004xv2

B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib

4XV3 | pdb_00004xv3

B-Raf Kinase V600E oncogenic mutant in complex with PLX7922

4XV9 | pdb_00004xv9

B-Raf Kinase domain in complex with PLX5568

5TXK | pdb_00005txk

CRYSTAL STRUCTURE OF USP35 C450S IN COMPLEX WITH UBIQUITIN

5WMA | pdb_00005wma

N-terminal bromodomain of BRD4 in complex with PLX5981

5WMD | pdb_00005wmd

N-terminal bromodomain of BRD4 in complex with OTX-015

5WMG | pdb_00005wmg

N-terminal bromodomain of BRD4 in complex with OTX-015

6N33 | pdb_00006n33

Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622

7KHG | pdb_00007khg

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX3397

7KHJ | pdb_00007khj

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX8512 in the DFG-in state

7KHK | pdb_00007khk

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX9486 (bezuclastinib) in the DFG-in state

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1JQH | pdb_00001jqh

3OG7 | pdb_00003og7

4HVS | pdb_00004hvs

4HW7 | pdb_00004hw7

4RT7 | pdb_00004rt7

4XV1 | pdb_00004xv1

4XV2 | pdb_00004xv2

4XV3 | pdb_00004xv3

4XV9 | pdb_00004xv9

5TXK | pdb_00005txk

5WMA | pdb_00005wma

5WMD | pdb_00005wmd

5WMG | pdb_00005wmg

6N33 | pdb_00006n33

7KHG | pdb_00007khg

7KHJ | pdb_00007khj

7KHK | pdb_00007khk