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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Chemical ID(s) = 4Z5

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Search Summary

This query matches 23 Structures.

Refinements

Structure Determination Methodology

experimental (23)

Scientific Name of Source Organism

	Homo sapiens (22)
	Mus musculus (1)
	synthetic construct (1)

Taxonomy

	Eukaryota (23)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (21)
	ELECTRON MICROSCOPY (2)

Polymer Entity Type

Protein (23)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (3)
	2.0 - 2.5 (9)
	2.5 - 3.0 (6)
	3.0 - 3.5 (2)
	4.0 - 4.5 (1)
	> 4.5 (1)

Release Date

	2005 - 2009 (3)
	2010 - 2014 (7)
	2015 - 2019 (3)
	2020 - 2024 (10)

Enzyme Classification Name

Hydrolases (23)

Symmetry Type

	Asymmetric (11)
	Cyclic (13)
	Dihedral (1)

AllSelected

1 to 23 of 23 Structures

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2G7R \| pdb_00002g7r	Download File View File

X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1

Walker, J.R., Wybenga-Groot, L., Newman, E.M., Finerty Jr., P.J., Butler-Cole, C., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)

To be published

Released	2006-04-04
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)

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3BFO \| pdb_00003bfo	Download File View File

Crystal structure of Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Walker, J.R., Akutsu, M., Littler, D.R., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)

To be published

Released	2007-12-11
Method	X-RAY DIFFRACTION 1.15 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Isoform 2) (protein)

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3K0W \| pdb_00003k0w	Download File View File

Crystal structure of the tandem IG-like C2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1

Walker, J.R., Qiu, L., Butler-Cole, C., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)

To be published

Released	2009-10-27
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1, isoform 2 (protein)
Unique Ligands	CL

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3UO8 \| pdb_00003uo8	Download File View File

Crystal structure of the MALT1 paracaspase (P1 form)

Jeffrey, P.D., Yu, J.W., Shi, Y.

(2011) Proc Natl Acad Sci U S A 108: 21004-21009

Released	2011-12-21
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein) Z-Val-Arg-Pro-DL-Arg-fluoromethylketone (protein)

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3UOA \| pdb_00003uoa	Download File View File

Crystal structure of the MALT1 paracaspase (P21 form)

Jeffrey, P.D., Yu, J.W., Shi, Y.

(2011) Proc Natl Acad Sci U S A 108: 21004-21009

Released	2011-12-21
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein) Z-Val-Arg-Pro-DL-Arg-fluoromethylketone (protein)
Unique Ligands	MG

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3V4L \| pdb_00003v4l	Download File View File

Mouse MALT1(caspase-IG3 domains) in complex with a irreversible peptidic inhibitor

Renatus, M., Wiesmann, C.

(2012) J Mol Biology 419: 4-21

Released	2012-03-14
Method	X-RAY DIFFRACTION 3.15 Å
Organisms	Mus musculus
Macromolecule	MALT1 Inhibitor (protein) Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (protein)

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3V4O \| pdb_00003v4o	Download File View File

Human MALT1 (caspase domain) in complex with an irreversible peptidic inhibitor

Renatus, M., Wiesmann, C.

(2012) J Mol Biology 419: 4-21

Released	2012-03-14
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	MALT1 Inhibitor (protein) Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)

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3V55 \| pdb_00003v55	Download File View File

Human MALT1 (334-719) in its ligand free form

Renatus, M., Wiesmann, C.

(2012) J Mol Biology 419: 4-21

Released	2012-03-14
Method	X-RAY DIFFRACTION 1.81 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)

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4I1P \| pdb_00004i1p	Download File View File

Human MALT1 (caspase-IG3) in complex with activity based-probe

Schlauderer, F., Lammens, K., Hopfner, K.P.

(2015) Chem Biol 22: 129-138

Released	2014-07-09
Method	X-RAY DIFFRACTION 2.403 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein) tetrapeptide (protein)
Unique Ligands	ACT

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4I1R \| pdb_00004i1r	Download File View File

Human MALT1 (caspase-IG3) in complex with thioridazine

Schlauderer, F., Lammens, K., Hopfner, K.P.

(2013) Angew Chem Int Ed Engl 52: 10384-10387

Released	2013-08-28
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	LZU

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6F7I \| pdb_00006f7i	Download File View File

human MALT1(329-728) IN COMPLEX WITH MLT-747

Renatus, M., Renatus, M.

(2019) Nat Chem Biol 15: 304-313

Released	2019-01-02
Method	X-RAY DIFFRACTION 2.43 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	CW5, GOL, MG

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6GK2 \| pdb_00006gk2	Download File View File

Helical reconstruction of BCL10 CARD and MALT1 DEATH DOMAIN complex

Schlauderer, F., Desfosses, A., Gutsche, I., Hopfner, K.P., Lammens, K.

(2018) Nat Commun 9: 4041-4041

Released	2018-10-31
Method	ELECTRON MICROSCOPY 4.9 Å
Organisms	Homo sapiens
Macromolecule	B-cell lymphoma/leukemia 10 (protein) Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)

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6H4A \| pdb_00006h4a	Download File View File

Human MALT1(329-728) in complex with MLT-748

Renatus, M., Renatus, M.

(2019) Nat Chem Biol 15: 304-313

Released	2019-02-13
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	FNB

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6YN8 \| pdb_00006yn8	Download File View File

Human MALT1(334-719) in complex with a tetrazole containing compound

Renatus, M.

(2020) Adv Ther (Weinh) 3:

Released	2020-06-24
Method	X-RAY DIFFRACTION 3.052 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	OZK

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6YN9 \| pdb_00006yn9	Download File View File

MALT1(329-728) in complex with a sulfonamide containing compound

Renatus, M.

(2020) Adv Ther (Weinh) 3:

Released	2020-06-24
Method	X-RAY DIFFRACTION 2.558 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	OZQ

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7A41 \| pdb_00007a41	Download File View File

MALT1 in complex with a NVS-MALT1 chemical probe

Renatus, M.

Not Published

Released	2020-12-02
Method	X-RAY DIFFRACTION 2.13 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	DMS, QYQ

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7AK0 \| pdb_00007ak0	Download File View File

Human MALT1(329-729) in complex with a chromane urea containing inhibitor

Renatus, M.

(2020) J Med Chem 63: 14576-14593

Released	2020-12-09
Method	X-RAY DIFFRACTION 2.316 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	RJK

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7AK1 \| pdb_00007ak1	Download File View File

Human MALT1(329-729) in complex with a chromane urea containing inhibitor

Renatus, M.

(2020) J Med Chem 63: 14576-14593

Released	2020-12-09
Method	X-RAY DIFFRACTION 2.507 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	MG, RJH

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7PAV \| pdb_00007pav	Download File View File

MALT1 in complex with compound 1

Kack, H., Oster, L.

(2021) Eur J Med Chem 227: 113925-113925

Released	2021-11-17
Method	X-RAY DIFFRACTION 2.199 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	6IO

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7PAW \| pdb_00007paw	Download File View File

MALT1 in complex with compound 1

Kack, H., Oster, L.

(2021) Eur J Med Chem 227: 113925-113925

Released	2021-11-17
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	6IT

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8CZO \| pdb_00008czo	Download File View File

Cryo-EM structure of BCL10 CARD - MALT1 DD filament

David, L., Wu, H.

(2022) Cancer Discov 12: 1922-1941

Released	2022-06-22
Method	ELECTRON MICROSCOPY 4.3 Å
Organisms	Homo sapiens
Macromolecule	B-cell lymphoma/leukemia 10 (protein) Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)

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8J5I \| pdb_00008j5i	Download File View File

MALT1 death domain

Lo, Y.C., Kuo, B.J.

To be published

Released	2024-04-24
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)

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8V4X \| pdb_00008v4x	Download File View File

Structure of MALT1 in complex with an allosteric inhibitor

Judge, R.A., Pappano, W.N.

(2024) Mol Cancer Ther 23: 949-960

Released	2024-05-01
Method	X-RAY DIFFRACTION 2.486 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	Inhibitor peptide (protein) Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (protein)
Unique Ligands	A1AAB

1 to 23 of 23 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

2G7R | pdb_00002g7r

3BFO | pdb_00003bfo

3K0W | pdb_00003k0w

3UO8 | pdb_00003uo8

3UOA | pdb_00003uoa

3V4L | pdb_00003v4l

3V4O | pdb_00003v4o

3V55 | pdb_00003v55

4I1P | pdb_00004i1p

4I1R | pdb_00004i1r

6F7I | pdb_00006f7i

6GK2 | pdb_00006gk2

6H4A | pdb_00006h4a

6YN8 | pdb_00006yn8

6YN9 | pdb_00006yn9

7A41 | pdb_00007a41

7AK0 | pdb_00007ak0

7AK1 | pdb_00007ak1

7PAV | pdb_00007pav

7PAW | pdb_00007paw

8CZO | pdb_00008czo

8J5I | pdb_00008j5i

8V4X | pdb_00008v4x