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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "ANPEP"

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Search Summary

This query matches 32 Structures.

Refinements

Structure Determination Methodology

experimental (32)

Scientific Name of Source Organism

	Sus scrofa (17)
	Homo sapiens (12)
	Human coronavirus 229E (5)
	Canis lupus familiaris (3)
	Porcine deltacoronavirus (3)
	Coronaviridae sp. (1)
	Felis catus (1)
	Porcine respiratory coronavirus (1)
	TGEV virulent Purdue (1)

Taxonomy

	Eukaryota (32)
	Riboviria (11)
	Eukaryota (eukaryotes) (1)

Experimental Method

	X-RAY DIFFRACTION (29)
	ELECTRON MICROSCOPY (3)

Polymer Entity Type

Protein (32)

Refinement Resolution (Å)

	1.5 - 2.0 (8)
	2.0 - 2.5 (10)
	2.5 - 3.0 (7)
	3.0 - 3.5 (5)
	3.5 - 4.0 (2)

Release Date

	2010 - 2014 (12)
	2015 - 2019 (13)
	2020 - 2024 (6)
	2025 - 2029 (1)

Enzyme Classification Name

Hydrolases (32)

Symmetry Type

	Asymmetric (25)
	Cyclic (7)

SCOP Classification

	All beta proteins (22)
	All alpha proteins (22)
	Alpha and beta proteins (a+b) (22)
	Artifacts (14)

AllSelected

1 to 25 of 32 Structures

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4F5C \| pdb_00004f5c	Download File View File

Crystal structure of the spike receptor binding domain of a porcine respiratory coronavirus in complex with the pig aminopeptidase N ectodomain

Santiago, C., Reguera, J., Gaurav, M., Ordono, D., Enjuanes, L., Casasnovas, J.M.

(2012) PLoS Pathog 8: e1002859-e1002859

Released	2012-08-22
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Porcine respiratory coronavirus Sus scrofa
Macromolecule	Aminopeptidase N (protein) PRCV spike protein (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

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4FKE \| pdb_00004fke	Download File View File

Crystal structure of porcine aminopeptidase-N

Chen, L., Lin, Y.L., Peng, G., Li, F.

(2012) Proc Natl Acad Sci U S A 109: 17966-17971

Released	2012-10-17
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

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4FKH \| pdb_00004fkh	Download File View File

Crystal structure of porcine aminopeptidase-N complexed with alanine

Chen, L., Lin, Y.L., Peng, G., Li, F.

(2012) Proc Natl Acad Sci U S A 109: 17966-17971

Released	2012-10-17
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	ALA, NAG, ZN
Unique branched monosaccharides	NAG

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4FKK \| pdb_00004fkk	Download File View File

Crystal structure of porcine aminopeptidase-N complexed with bestatin

Chen, L., Lin, Y.L., Peng, G., Li, F.

(2012) Proc Natl Acad Sci U S A 109: 17966-17971

Released	2012-10-17
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	BES, NAG, ZN
Unique branched monosaccharides	NAG

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4FYQ \| pdb_00004fyq	Download File View File

Human aminopeptidase N (CD13)

Wong, A.H., Rini, J.M.

(2012) J Biological Chem 287: 36804-36813

Released	2012-09-05
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	ACY, NAG, SO4, ZN
Unique branched monosaccharides	BMA, NAG

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4FYR \| pdb_00004fyr	Download File View File

Human aminopeptidase N (CD13) in complex with bestatin

Wong, A.H., Rini, J.M.

(2012) J Biological Chem 287: 36804-36813

Released	2012-09-05
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Homo sapiens
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	ACY, BES, NAG, SO4, ZN
Unique branched monosaccharides	BMA, NAG

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4FYS \| pdb_00004fys	Download File View File

Human aminopeptidase N (CD13) in complex with angiotensin IV

Wong, A.H., Rini, J.M.

(2012) J Biological Chem 287: 36804-36813

Released	2012-09-05
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Homo sapiens
Macromolecule	Aminopeptidase N (protein) Angiotensin IV (protein)
Unique Ligands	NAG, SO4
Unique branched monosaccharides	BMA, NAG

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4FYT \| pdb_00004fyt	Download File View File

Human aminopeptidase N (CD13) in complex with amastatin

Wong, A.H., Rini, J.M.

(2012) J Biological Chem 287: 36804-36813

Released	2012-09-05
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	AMASTATIN (protein) Aminopeptidase N (protein)
Unique Ligands	NAG, SO4, ZN
Unique branched monosaccharides	NAG

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4HOM \| pdb_00004hom	Download File View File

Crystal structure of porcine aminopeptidase-N complexed with substance P

Chen, L., Lin, Y.L., Peng, G., Li, F.

(2012) Proc Natl Acad Sci U S A 109: 17966-17971

Released	2012-10-31
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens Sus scrofa
Macromolecule	Aminopeptidase N (protein) substance P (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

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4NAQ \| pdb_00004naq	Download File View File

Crystal structure of porcine aminopeptidase-N complexed with poly-alanine

Chen, L., Lin, Y.L., Peng, G., Li, F.

(2012) Proc Natl Acad Sci U S A 109: 17966-17971

Released	2013-12-04
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein) poly A peptide (protein)
Unique Ligands	NAG, SO4, ZN
Unique branched monosaccharides	NAG

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4NZ8 \| pdb_00004nz8	Download File View File

Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine

Chen, L., Lin, Y.L., Peng, G., Li, F.

(2012) Proc Natl Acad Sci U S A 109: 17966-17971

Released	2013-12-25
Method	X-RAY DIFFRACTION 2 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein) CLEAVED poly-Ala (protein)
Unique Ligands	NAG, SO4, ZN
Unique branched monosaccharides	NAG

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4OU3 \| pdb_00004ou3	Download File View File

Crystal structure of porcine aminopeptidase N complexed with CNGRCG tumor-homing peptide

Liu, C., Yang, Y., Chen, L., Lin, Y.-L., Li, F.

(2014) J Biological Chem 289: 34520-34529

Released	2014-11-05
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein) tumor-homing peptide (protein)
Unique Ligands	NAG, SO4, ZN
Unique branched monosaccharides	NAG

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5LDS \| pdb_00005lds	Download File View File

Structure of the porcine aminopeptidase N ectodomain

Santiago, C., Reguera, J., Mudgal, G., Casasnovas, J.M.

(2017) Sci Rep 7: 46045-46045

Released	2017-04-05
Method	X-RAY DIFFRACTION 2 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	ACT, NAG, ZN
Unique branched monosaccharides	BMA, NAG

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5LG6 \| pdb_00005lg6	Download File View File

Structure of the deglycosylated porcine aminopeptidase N ectodomain

Santiago, C., Reguera, J., Mudgal, G., Casasnovas, J.M.

(2017) Sci Rep 7: 46045-46045

Released	2017-04-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	NAG, ZN

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5LHD \| pdb_00005lhd	Download File View File

Structure of glycosylated human aminopeptidase N

Recacha, R., Mudgal, G., Santiago, C., Casasnovas, J.M.

(2017) Sci Rep 7: 46045-46045

Released	2017-04-05
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	EDO, NAG, ZN
Unique branched monosaccharides	BMA, NAG

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5Z65 \| pdb_00005z65	Download File View File

Crystal structure of porcine aminopeptidase N ectodomain in functional form

Sun, Y.G., Li, R., Jiang, L.G., Qiao, S.L., Zhang, G.P.

(2018) Int J Biol Macromol 117: 704-712

Released	2019-01-02
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

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6ATK \| pdb_00006atk	Download File View File

Crystal structure of the human coronavirus 229E spike protein receptor binding domain in complex with human aminopeptidase N

Wong, A.H., Rini, J.M.

(2017) Nat Commun 8: 1735-1735

Released	2017-12-06
Method	X-RAY DIFFRACTION 3.505 Å
Organisms	Homo sapiens Human coronavirus 229E
Macromolecule	Aminopeptidase N (protein) Spike glycoprotein (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

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6BV0 \| pdb_00006bv0	Download File View File

Crystal structure of porcine aminopeptidase-N with Arginine

Chen, L., Lin, Y.-L., Li, F.

(2017) Sci Rep 7: 1424

Released	2018-01-17
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	ARG, NAG, SO4, ZN
Unique branched monosaccharides	NAG

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6BV1 \| pdb_00006bv1	Download File View File

Crystal structure of porcine aminopeptidase-N with Aspartic acid

Chen, L., Lin, Y.-L., Li, F.

(2017) Sci Rep 7: 1424

Released	2018-01-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	ASP, NAG, SO4, ZN
Unique branched monosaccharides	NAG

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6BV2 \| pdb_00006bv2	Download File View File

Crystal structure of porcine aminopeptidase-N with Isoleucine

Chen, L., Lin, Y.-L., Li, F.

(2017) Sci Rep 7: 1424

Released	2018-01-17
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	ILE, NAG, SO4, ZN
Unique branched monosaccharides	NAG

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6BV3 \| pdb_00006bv3	Download File View File

Crystal structure of porcine aminopeptidase-N with Leucine

Chen, L., Lin, Y.-L., Li, F.

(2017) Sci Rep 7: 1424

Released	2018-01-17
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	LEU, NAG, SO4, ZN
Unique branched monosaccharides	NAG

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6BV4 \| pdb_00006bv4	Download File View File

Crystal structure of porcine aminopeptidase-N with Methionine

Chen, L., Lin, Y.-L., Li, F.

(2017) Sci Rep 7: 1424

Released	2018-01-10
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	MET, NAG, SO4, ZN
Unique branched monosaccharides	NAG

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6U7E \| pdb_00006u7e	Download File View File

HCoV-229E RBD Class III in complex with human APN

Tomlinson, A.C.A., Li, Z., Rini, J.M.

(2019) Elife 8:

Released	2019-11-13
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens Human coronavirus 229E
Macromolecule	Aminopeptidase N (protein) Spike glycoprotein (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	BMA, NAG

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6U7F \| pdb_00006u7f	Download File View File

HCoV-229E RBD Class IV in complex with human APN

Tomlinson, A.C.A., Li, Z., Rini, J.M.

(2019) Elife 8:

Released	2019-11-13
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens Human coronavirus 229E
Macromolecule	Aminopeptidase N (protein) Spike glycoprotein (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

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6U7G \| pdb_00006u7g	Download File View File

HCoV-229E RBD Class V in complex with human APN

Tomlinson, A., Li, Z., Rini, J.M.

(2019) Elife 8:

Released	2019-11-13
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens Human coronavirus 229E
Macromolecule	Aminopeptidase N (protein) Spike protein (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

1 to 25 of 32 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4F5C | pdb_00004f5c

4FKE | pdb_00004fke

4FKH | pdb_00004fkh

4FKK | pdb_00004fkk

4FYQ | pdb_00004fyq

4FYR | pdb_00004fyr

4FYS | pdb_00004fys

4FYT | pdb_00004fyt

4HOM | pdb_00004hom

4NAQ | pdb_00004naq

4NZ8 | pdb_00004nz8

4OU3 | pdb_00004ou3

5LDS | pdb_00005lds

5LG6 | pdb_00005lg6

5LHD | pdb_00005lhd

5Z65 | pdb_00005z65

6ATK | pdb_00006atk

6BV0 | pdb_00006bv0

6BV1 | pdb_00006bv1

6BV2 | pdb_00006bv2

6BV3 | pdb_00006bv3

6BV4 | pdb_00006bv4

6U7E | pdb_00006u7e

6U7F | pdb_00006u7f

6U7G | pdb_00006u7g