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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "ITGAV"

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Search Summary

This query matches 50 Structures.

Refinements

Structure Determination Methodology

experimental (50)

Scientific Name of Source Organism

	Homo sapiens (48)
	Mus musculus (12)
	Foot-and-mouth disease virus (3)
	Ecballium elaterium (2)
	synthetic construct (2)
	Caulobacter vibrioides (1)
	Caulobacter vibrioides CB15 (1)
	Foot-and-mouth disease virus O (1)
	Sus scrofa (1)

Taxonomy

	Eukaryota (48)
	Riboviria (4)
	Bacteria (2)
	other sequences (2)

Experimental Method

	ELECTRON MICROSCOPY (27)
	X-RAY DIFFRACTION (23)

Polymer Entity Type

Protein (50)

Refinement Resolution (Å)

	2.0 - 2.5 (5)
	2.5 - 3.0 (14)
	3.0 - 3.5 (20)
	3.5 - 4.0 (3)
	> 4.5 (8)

Release Date

	2000 - 2004 (1)
	2010 - 2014 (9)
	2015 - 2019 (16)
	2020 - 2024 (22)
	2025 - 2029 (2)

Enzyme Classification Name

Hydrolases (1)

Membrane Protein Annotation

mpstruc (2)

Symmetry Type

	Asymmetric (49)
	Cyclic (1)
	Icosahedral (1)

SCOP Classification

	All beta proteins (13)
	Artifacts (1)
	Small proteins (1)
	Alpha and beta proteins (a+b) (1)
	Alpha and beta proteins (a/b) (1)

AllSelected

1 to 25 of 50 Structures

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1U8C \| pdb_00001u8c	Download File View File

A novel adaptation of the integrin PSI domain revealed from its crystal structure

Xiong, J.P., Stehle, T., Goodman, S.L., Arnaout, M.A.

(2004) J Biological Chem 279: 40252-40254

Released	2004-12-28
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	CA, NAG
Unique branched monosaccharides	NAG, NDG

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4EKJ \| pdb_00004ekj	Download File View File

Crystal structure of a monomeric beta-xylosidase from Caulobacter crescentus CB15

Santos, C.R., Polo, C.C., Correa, J.M., Simao, R.C.G., Seixas, F.A.V., Murakami, M.T.

(2012) Acta Crystallogr D Biol Crystallogr 68: 1339-1345

Released	2012-09-26
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Caulobacter vibrioides
Macromolecule	Beta-xylosidase (protein)
Unique Ligands	SO4

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4G1E \| pdb_00004g1e	Download File View File

Crystal structure of integrin alpha V beta 3 with coil-coiled tag.

Dong, X., Mi, L., Zhu, J., Wang, W., Luo, B., Springer, T.A.

(2012) Biochemistry 51: 8814-8828

Released	2012-12-12
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	CA, CL, NAG, NI, SO4
Unique branched monosaccharides	BMA, MAN, NAG

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4G1M \| pdb_00004g1m	Download File View File

Re-refinement of alpha V beta 3 structure

Springer, T.A., Mi, L., Zhu, J.

(2012) Biochemistry 51: 8814-8828

Released	2012-12-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	CA, NA, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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4M29 \| pdb_00004m29	Download File View File

Structure of a GH39 Beta-xylosidase from Caulobacter crescentus

Polo, C.C., Santos, C.R., Correa, J.M., Simao, R.C.G., Seixas, F.A.V., Murakami, M.T.

Thesis

Released	2013-08-14
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Caulobacter vibrioides CB15
Macromolecule	Beta-xylosidase (protein)
Unique Ligands	MES

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4MMX \| pdb_00004mmx	Download File View File

Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin

van Agthoven, J., Xiong, J., Arnaout, M.A.

(2014) Nat Struct Mol Biol 21: 383-388

Released	2014-03-26
Method	X-RAY DIFFRACTION 3.32 Å
Organisms	Homo sapiens
Macromolecule	Fibronectin (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	MN, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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4MMY \| pdb_00004mmy	Download File View File

Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif

van Agthoven, J., Xiong, J., Arnaout, M.A.

(2014) Nat Struct Mol Biol 21: 383-388

Released	2014-03-26
Method	X-RAY DIFFRACTION 3.183 Å
Organisms	Homo sapiens
Macromolecule	Fibronectin (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	MN, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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4MMZ \| pdb_00004mmz	Download File View File

Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin

van Agthoven, J., Xiong, J., Arnaout, M.A.

(2014) Nat Struct Mol Biol 21: 383-388

Released	2014-03-26
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Fibronectin (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	GOL, MN, NA, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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4O02 \| pdb_00004o02	Download File View File

AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment.

Mahalingam, B., van Agthoven, J., Xiong, J., Arnaout, M.A.

(2014) J Biological Chem 289: 13801-13809

Released	2014-04-02
Method	X-RAY DIFFRACTION 3.605 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	17E6 heavy chain (protein) 17E6 light chain (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	MN, NAG, NO3
Unique branched monosaccharides	BMA, MAN, NAG

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4UM9 \| pdb_00004um9	Download File View File

Crystal structure of alpha V beta 6 with peptide

Dong, X., Springer, T.A.

(2014) Nat Struct Mol Biol 21: 1091

Released	2014-11-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-V heavy chain (protein) Integrin beta-6 (protein) Latency-associated peptide (protein)
Unique Ligands	CA, MAN, MG, NAG, SO4
Unique branched monosaccharides	BMA, MAN, NAG

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5FFG \| pdb_00005ffg	Download File View File

Crystal structure of integrin alpha V beta 6 head

Dong, X., Springer, T.A.

(2017) Nature 542: 55-59

Released	2017-01-25
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-V (protein) Integrin beta-6 (protein)
Unique Ligands	CA, MES, NAG, PEG, SO4
Unique branched monosaccharides	BMA, MAN, NAG

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5FFO \| pdb_00005ffo	Download File View File

Integrin alpha V beta 6 in complex with pro-TGF-beta

Dong, X., Zhao, B., Springer, T.A.

(2017) Nature 542: 55-59

Released	2017-01-25
Method	X-RAY DIFFRACTION 3.49 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-V (protein) Integrin beta-6 (protein) Transforming growth factor beta-1 (protein)
Unique Ligands	CA, MN, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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5NEM \| pdb_00005nem	Download File View File

Localised reconstruction of alpha v beta 6 bound to Foot and Mouth Disease Virus O PanAsia - Pose A.

Kotecha, A., Stuart, D.

(2017) Nat Commun 8: 15408-15408

Released	2017-06-21
Method	ELECTRON MICROSCOPY 10.8 Å
Organisms	Foot-and-mouth disease virus O Homo sapiens
Macromolecule	Unique protein chains: 6
Unique Ligands	CA, MAN, NAG
Unique branched monosaccharides	MAN, NAG

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5NER \| pdb_00005ner	Download File View File

Localised reconstruction of alpha v beta 6 bound to Foot and Mouth Disease Virus O PanAsia - Pose A prime.

Kotecha, A., Stuart, D.

(2017) Nat Commun 8: 15408-15408

Released	2017-06-21
Method	ELECTRON MICROSCOPY 11.5 Å
Organisms	Foot-and-mouth disease virus Homo sapiens
Macromolecule	Unique protein chains: 6
Unique Ligands	CA, MAN, NAG
Unique branched monosaccharides	MAN, NAG

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5NET \| pdb_00005net	Download File View File

Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose A.

Kotecha, A., Stuart, D.

(2017) Nat Commun 8: 15408-15408

Released	2017-06-21
Method	ELECTRON MICROSCOPY 8.6 Å
Organisms	Foot-and-mouth disease virus Homo sapiens
Macromolecule	Unique protein chains: 6
Unique Ligands	CA, MAN, NAG
Unique branched monosaccharides	MAN, NAG

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5NEU \| pdb_00005neu	Download File View File

Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose B.

Kotecha, A., Stuart, D.

(2017) Nat Commun 8: 15408-15408

Released	2017-06-21
Method	ELECTRON MICROSCOPY 12.3 Å
Organisms	Foot-and-mouth disease virus Homo sapiens
Macromolecule	Unique protein chains: 6
Unique Ligands	CA, MG

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6AVQ \| pdb_00006avq	Download File View File

The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance

Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D.

(2017) Structure 25: 1732-1739.e5

Released	2017-11-01
Method	ELECTRON MICROSCOPY 35 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Integrin alpha-V (protein) Integrin beta-3 (protein) LM609 Fab heavy chain (protein) LM609 Fab light chain (protein)

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6AVR \| pdb_00006avr	Download File View File

Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609

Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D.

(2017) Structure 25: 1732-1739.e5

Released	2017-11-01
Method	ELECTRON MICROSCOPY 35 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Fab LM609 heavy chain (protein) Fab LM609 light chain (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)

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6AVU \| pdb_00006avu	Download File View File

Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609

Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D.

(2017) Structure 25: 1732-1739.e5

Released	2017-11-01
Method	ELECTRON MICROSCOPY 35 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Fab LM609 heavy chain (protein) Fab LM609 light chain (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)

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6DJP \| pdb_00006djp	Download File View File

Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68

Cormier, A., Campbell, M.G., Nishimura, S.L., Cheng, Y.

(2018) Nat Struct Mol Biol 25: 698-704

Released	2018-07-25
Method	ELECTRON MICROSCOPY 4.8 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Unique protein chains: 6
Unique Ligands	NAG
Unique branched monosaccharides	BMA, MAN, NAG

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6MK0 \| pdb_00006mk0	Download File View File

Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161

van Agthoven, J., Arnaout, M.A.

(2019) Acs Pharmacol Transl Sci 2: 387-401

Released	2019-09-25
Method	X-RAY DIFFRACTION 3.005 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	JUY, MN, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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6MSL \| pdb_00006msl	Download File View File

Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D

van Agthoven, J.F., Arnaout, M.A.

(2019) Structure 27: 1443-1451.e6

Released	2019-10-23
Method	X-RAY DIFFRACTION 3.104 Å
Organisms	Ecballium elaterium Homo sapiens
Macromolecule	Cystine Knot Protein 2.5D (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	MN, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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6MSU \| pdb_00006msu	Download File View File

Integrin alphaVBeta3 in complex with EETI-II 2.5F

van Agthoven, J.F., Arnaout, M.A.

(2019) Structure 27: 1443-1451.e6

Released	2019-10-23
Method	X-RAY DIFFRACTION 3.11 Å
Organisms	Ecballium elaterium Homo sapiens
Macromolecule	Engineered EETI-II 2.5F (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	CL, MN, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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6NAJ \| pdb_00006naj	Download File View File

Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.

van Agthoven, J., Arnaout, M.A.

(2020) Nat Commun 11: 398-398

Released	2019-12-11
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Fibronectin, HR10 variant (protein) Integrin alpha-V (protein) Integrin beta-3 (protein)
Unique Ligands	MN, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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6OM1 \| pdb_00006om1	Download File View File

Crystal structure of an atypical integrin

Wang, J.C., Springer, T.A.

(2019) Nat Commun 10: 5481-5481

Released	2019-12-11
Method	X-RAY DIFFRACTION 2.66 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-V (protein) Integrin beta-8 (protein)
Unique Ligands	CA, EDO, MES, MG, NAG
Unique branched monosaccharides	BMA, MAN, NAG

1 to 25 of 50 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1U8C | pdb_00001u8c

4EKJ | pdb_00004ekj

4G1E | pdb_00004g1e

4G1M | pdb_00004g1m

4M29 | pdb_00004m29

4MMX | pdb_00004mmx

4MMY | pdb_00004mmy

4MMZ | pdb_00004mmz

4O02 | pdb_00004o02

4UM9 | pdb_00004um9

5FFG | pdb_00005ffg

5FFO | pdb_00005ffo

5NEM | pdb_00005nem

5NER | pdb_00005ner

5NET | pdb_00005net

5NEU | pdb_00005neu

6AVQ | pdb_00006avq

6AVR | pdb_00006avr

6AVU | pdb_00006avu

6DJP | pdb_00006djp

6MK0 | pdb_00006mk0

6MSL | pdb_00006msl

6MSU | pdb_00006msu

6NAJ | pdb_00006naj

6OM1 | pdb_00006om1