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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 1.1.1

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Search Summary

This query matches 3,224 Structures.

Refinements

Structure Determination Methodology

experimental (3,224)

Scientific Name of Source Organism

	Homo sapiens (876)
	Escherichia coli (125)
	Equus caballus (102)
	Mycobacterium tuberculosis H37Rv (82)
	Rattus norvegicus (60)
	Escherichia coli K-12 (59)
	Saccharomyces cerevisiae (56)
	Mus musculus (50)
	Thermus thermophilus HB8 (42)
	Pseudomonas aeruginosa PAO1 (35)

More...

Taxonomy

	Eukaryota (1,660)
	Bacteria (1,415)
	Archaea (148)
	other sequences (6)
	Eukaryota (eukaryotes) (2)
	Varidnaviria (1)
	unclassified sequences (1)

Experimental Method

	X-RAY DIFFRACTION (3,022)
	ELECTRON MICROSCOPY (198)
	SOLUTION NMR (4)
	NEUTRON DIFFRACTION (1)
	SOLUTION SCATTERING (1)

Polymer Entity Type

	Protein (3,224)
	RNA (13)
	DNA (3)

Refinement Resolution (Å)

	0.5 - 1.0 (48)
	1.0 - 1.5 (244)
	1.5 - 2.0 (960)
	2.0 - 2.5 (1,119)
	2.5 - 3.0 (612)
	3.0 - 3.5 (179)
	3.5 - 4.0 (35)
	4.0 - 4.5 (14)
	> 4.5 (10)

Release Date

	1975 - 1979 (1)
	1980 - 1984 (4)
	1985 - 1989 (9)
	1990 - 1994 (37)
	1995 - 1999 (129)
	2000 - 2004 (354)
	2005 - 2009 (532)
	2010 - 2014 (696)
	2015 - 2019 (690)
	2020 - 2024 (713)

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Enzyme Classification Name

	Oxidoreductases (3,224)
	Transferases (175)
	Lyases (136)
	Hydrolases (106)
	Isomerases (31)

Membrane Protein Annotation

	PDBTM (19)
	OPM (20)
	mpstruc (15)
	MemProtMD (13)

Symmetry Type

	Cyclic (1,621)
	Dihedral (1,035)
	Asymmetric (734)
	Tetrahedral (25)
	Helical (3)

SCOP Classification

	Alpha and beta proteins (a/b) (1,807)
	Alpha and beta proteins (a+b) (339)
	Artifacts (361)
	All alpha proteins (166)
	All beta proteins (110)
	Multi-domain proteins (alpha and beta) (32)
	Peptides (2)
	Low resolution protein structures (2)
	Small proteins (2)

AllSelected

1 to 25 of 3,224 Structures

Page 1 of 129

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1A05 \| pdb_00001a05	Download File View File

CRYSTAL STRUCTURE OF THE COMPLEX OF 3-ISOPROPYLMALATE DEHYDROGENASE FROM THIOBACILLUS FERROOXIDANS WITH 3-ISOPROPYLMALATE

Imada, K., Inagaki, K., Matsunami, H., Kawaguchi, H., Tanaka, H., Tanaka, N., Namba, K.

(1998) Structure 6: 971-982

Released	1998-06-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Acidithiobacillus ferrooxidans
Macromolecule	3-ISOPROPYLMALATE DEHYDROGENASE (protein)
Unique Ligands	IPM, MG

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1A27 \| pdb_00001a27	Download File View File

HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 C-TERMINAL DELETION MUTANT COMPLEXED WITH ESTRADIOL AND NADP+

Mazza, C., Breton, R., Housset, D., Fontecilla-Camps, J.-C.

(1997) Thesis

Released	1998-05-27
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	17-BETA-HYDROXYSTEROID-DEHYDROGENASE (protein)
Unique Ligands	EST, NAP

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1A4U \| pdb_00001a4u	Download File View File

ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS

Benach, J., Atrian, S., Gonzalez-Duarte, R., Ladenstein, R.

(1998) J Mol Biology 282: 383-399

Released	1999-02-16
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Scaptodrosophila lebanonensis
Macromolecule	ALCOHOL DEHYDROGENASE (protein)

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1A5Z \| pdb_00001a5z	Download File View File

LACTATE DEHYDROGENASE FROM THERMOTOGA MARITIMA (TMLDH)

Auerbach, G., Ostendorp, R., Prade, L., Korndoerfer, I., Dams, T., Huber, R., Jaenicke, R.

(1998) Structure 6: 769-781

Released	1999-03-23
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Thermotoga maritima
Macromolecule	L-LACTATE DEHYDROGENASE (protein)
Unique Ligands	CD, FBP, NAD, OXM

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1A71 \| pdb_00001a71	Download File View File

TERNARY COMPLEX OF AN ACTIVE SITE DOUBLE MUTANT OF HORSE LIVER ALCOHOL DEHYDROGENASE, PHE93=>TRP, VAL203=>ALA WITH NAD AND TRIFLUOROETHANOL

Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.

(1998) Biochemistry 37: 9295-9304

Released	1998-06-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Equus caballus
Macromolecule	LIVER ALCOHOL DEHYDROGENASE (protein)
Unique Ligands	ETF, NAD, ZN

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1A72 \| pdb_00001a72	Download File View File

AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH THE ISOSTERIC NAD ANALOG CPAD

Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.

(1998) Biochemistry 37: 9295-9304

Released	1998-06-17
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Equus caballus
Macromolecule	HORSE LIVER ALCOHOL DEHYDROGENASE (protein)
Unique Ligands	PAD, ZN

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1A80 \| pdb_00001a80	Download File View File

Native 2,5-DIKETO-D-GLUCONIC acid reductase a from CORYNBACTERIUM SP. complexed with nadph

Khurana, S., Powers, D.B., Anderson, S., Blaber, M.

(1998) Proc Natl Acad Sci U S A 95: 6768-6773

Released	1999-03-30
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Corynebacterium sp.
Macromolecule	2,5-DIKETO-D-GLUCONIC ACID REDUCTASE A (protein)
Unique Ligands	NDP

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1ABN \| pdb_00001abn	Download File View File

THE CRYSTAL STRUCTURE OF THE ALDOSE REDUCTASE NADPH BINARY COMPLEX

Borhani, D.W., Harter, T.M., Petrash, J.M.

(1992) J Biological Chem 267: 24841-24847

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	ALDOSE REDUCTASE (protein)
Unique Ligands	NDP

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1ADB \| pdb_00001adb	Download File View File

CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES

Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.

(1994) Biochemistry 33: 11734-11744

Released	1995-06-03
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Equus caballus
Macromolecule	ALCOHOL DEHYDROGENASE (protein)
Unique Ligands	CND, EOH, ZN

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1ADC \| pdb_00001adc	Download File View File

CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES

Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.

(1994) Biochemistry 33: 11734-11744

Released	1995-06-03
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Equus caballus
Macromolecule	ALCOHOL DEHYDROGENASE (protein)
Unique Ligands	EOH, PAD, ZN

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1ADF \| pdb_00001adf	Download File View File

CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN

Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.

(1994) Biochemistry 33: 23-32

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Equus caballus
Macromolecule	ALCOHOL DEHYDROGENASE (protein)
Unique Ligands	TAD, ZN

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1ADG \| pdb_00001adg	Download File View File

CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN

Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.

(1994) Biochemistry 33: 23-32

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Equus caballus
Macromolecule	ALCOHOL DEHYDROGENASE (protein)
Unique Ligands	SAD, ZN

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1ADS \| pdb_00001ads	Download File View File

AN UNLIKELY SUGAR SUBSTRATE SITE IN THE 1.65 ANGSTROMS STRUCTURE OF THE HUMAN ALDOSE REDUCTASE HOLOENZYME IMPLICATED IN DIABETIC COMPLICATIONS

Wilson, D.K., Quiocho, F.A.

(1992) Science 257: 81-84

Released	1993-10-31
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	ALDOSE REDUCTASE (protein)
Unique Ligands	NAP

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1AE1 \| pdb_00001ae1	Download File View File

TROPINONE REDUCTASE-I COMPLEX WITH NADP

Nakajima, K., Yamashita, A., Akama, H., Nakatsu, T., Kato, H., Hashimoto, T., Oda, J., Yamada, Y.

(1998) Proc Natl Acad Sci U S A 95: 4876-4881

Released	1998-11-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Datura stramonium
Macromolecule	TROPINONE REDUCTASE-I (protein)
Unique Ligands	NAP

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1AE4 \| pdb_00001ae4	Download File View File

ALDEHYDE REDUCTASE COMPLEXED WITH COFACTOR AND INHIBITOR, ALPHA CARBON ATOMS ONLY

El-Kabbani, O.

(1997) Proteins 29: 186-192

Released	1998-03-11
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Sus scrofa
Macromolecule	ALDEHYDE REDUCTASE (protein)
Unique Ligands	NAP, TOL

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1AFS \| pdb_00001afs	Download File View File

RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE

Bennett, M.J., Albert, R.H., Jez, J.M., Ma, H., Penning, T.M., Lewis, M.

(1997) Structure 5: 799-812

Released	1997-10-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Rattus norvegicus
Macromolecule	3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (protein)
Unique Ligands	NAP, TES

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1AGN \| pdb_00001agn	Download File View File

X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE

Hurley, T.D., Xie, P.

(1997) J Biological Chem 272: 18558-18563

Released	1997-03-12
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	HUMAN SIGMA ALCOHOL DEHYDROGENASE (protein)
Unique Ligands	ACT, NAD, ZN

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1AH0 \| pdb_00001ah0	Download File View File

PIG ALDOSE REDUCTASE COMPLEXED WITH SORBINIL

Moras, D., Podjarny, A.D.

(1997) Structure 5: 601-612

Released	1998-04-15
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Sus scrofa
Macromolecule	ALDOSE REDUCTASE (protein)
Unique Ligands	NAP, SBI

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1AH3 \| pdb_00001ah3	Download File View File

ALDOSE REDUCTASE COMPLEXED WITH TOLRESTAT INHIBITOR

Moras, D., Podjarny, A.

(1997) Structure 5: 601-612

Released	1998-04-15
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Sus scrofa
Macromolecule	ALDOSE REDUCTASE (protein)
Unique Ligands	NAP, TOL

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1AH4 \| pdb_00001ah4	Download File View File

PIG ALDOSE REDUCTASE, HOLO FORM

Moras, D., Podjarny, A.

(1997) Structure 5: 601-612

Released	1998-04-15
Method	X-RAY DIFFRACTION 2 Å
Organisms	Sus scrofa
Macromolecule	ALDOSE REDUCTASE (protein)
Unique Ligands	NAP

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1AHH \| pdb_00001ahh	Download File View File

7 ALPHA-HYDROXYSTEROID DEHYDROGENASE COMPLEXED WITH NAD+

Tanaka, N., Nonaka, T., Mitsui, Y.

(1996) Biochemistry 35: 7715-7730

Released	1996-10-14
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Escherichia coli
Macromolecule	7 ALPHA-HYDROXYSTEROID DEHYDROGENASE (protein)
Unique Ligands	NAD

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1AHI \| pdb_00001ahi	Download File View File

7 ALPHA-HYDROXYSTEROID DEHYDROGENASE COMPLEXED WITH NADH AND 7-OXO GLYCOCHENODEOXYCHOLIC ACID

Tanaka, N., Nonaka, T., Mitsui, Y.

(1996) Biochemistry 35: 7715-7730

Released	1996-10-14
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Escherichia coli
Macromolecule	7 ALPHA-HYDROXYSTEROID DEHYDROGENASE (protein)
Unique Ligands	CHO, NAI

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1AI2 \| pdb_00001ai2	Download File View File

ISOCITRATE DEHYDROGENASE COMPLEXED WITH ISOCITRATE, NADP+, AND CALCIUM (FLASH-COOLED)

Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.

(1997) Science 277: 202-206

Released	1997-10-15
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Escherichia coli
Macromolecule	ISOCITRATE DEHYDROGENASE (protein)
Unique Ligands	ICA, NAP

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1AI3 \| pdb_00001ai3	Download File View File

ORBITAL STEERING IN THE CATALYTIC POWER OF ENZYMES: SMALL STRUCTURAL CHANGES WITH LARGE CATALYTIC CONSEQUENCES

Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.

(1997) Science 277: 202-206

Released	1997-11-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Escherichia coli
Macromolecule	ISOCITRATE DEHYDROGENASE (protein)
Unique Ligands	ICT, MG, NDO

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1AK5 \| pdb_00001ak5	Download File View File

INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) FROM TRITRICHOMONAS FOETUS

Whitby, F.G.

(1997) Biochemistry 36: 10666-10674

Released	1997-09-17
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Tritrichomonas suis
Macromolecule	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (protein)
Unique Ligands	SO4

1 to 25 of 3,224 Structures

Page 1 of 129

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1A05 | pdb_00001a05

1A27 | pdb_00001a27

1A4U | pdb_00001a4u

1A5Z | pdb_00001a5z

1A71 | pdb_00001a71

1A72 | pdb_00001a72

1A80 | pdb_00001a80

1ABN | pdb_00001abn

1ADB | pdb_00001adb

1ADC | pdb_00001adc

1ADF | pdb_00001adf

1ADG | pdb_00001adg

1ADS | pdb_00001ads

1AE1 | pdb_00001ae1

1AE4 | pdb_00001ae4

1AFS | pdb_00001afs

1AGN | pdb_00001agn

1AH0 | pdb_00001ah0

1AH3 | pdb_00001ah3

1AH4 | pdb_00001ah4

1AHH | pdb_00001ahh

1AHI | pdb_00001ahi

1AI2 | pdb_00001ai2

1AI3 | pdb_00001ai3

1AK5 | pdb_00001ak5