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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 3.6.5

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Search Summary

This query matches 3,670 Structures.

Refinements

Structure Determination Methodology

experimental (3,670)

Scientific Name of Source Organism

	Homo sapiens (2,617)
	Rattus norvegicus (492)
	Bos taurus (481)
	Mus musculus (452)
	synthetic construct (308)
	Gallus gallus (260)
	Sus scrofa (232)
	Lama glama (164)
	Saccharomyces cerevisiae (155)
	Escherichia coli (150)

More...

Taxonomy

	Eukaryota (3,438)
	Bacteria (343)
	other sequences (308)
	Archaea (76)
	Riboviria (51)
	Duplodnaviria (30)
	Eukaryota (eukaryotes) (15)
	unclassified sequences (13)
	Monodnaviria (7)
	Varidnaviria (1)

Experimental Method

	X-RAY DIFFRACTION (2,062)
	ELECTRON MICROSCOPY (1,534)
	SOLUTION NMR (66)
	ELECTRON CRYSTALLOGRAPHY (7)
	NEUTRON DIFFRACTION (1)

Polymer Entity Type

	Protein (3,670)
	RNA (187)
	DNA (1)

Refinement Resolution (Å)

	1.0 - 1.5 (183)
	1.5 - 2.0 (580)
	2.0 - 2.5 (698)
	2.5 - 3.0 (789)
	3.0 - 3.5 (745)
	3.5 - 4.0 (279)
	4.0 - 4.5 (117)
	> 4.5 (213)

Release Date

	1990 - 1994 (20)
	1995 - 1999 (70)
	2000 - 2004 (142)
	2005 - 2009 (261)
	2010 - 2014 (394)
	2015 - 2019 (732)
	2020 - 2024 (1,933)
	2025 - 2029 (118)

Enzyme Classification Name

	Hydrolases (3,670)
	Transferases (219)
	Lyases (81)
	Isomerases (48)
	Ligases (38)
	Oxidoreductases (17)
	Translocases (3)

Membrane Protein Annotation

	PDBTM (848)
	mpstruc (557)
	OPM (452)
	MemProtMD (438)

Symmetry Type

	Asymmetric (3,350)
	Cyclic (312)
	Helical (67)
	Dihedral (27)

SCOP Classification

	Alpha and beta proteins (a/b) (1,227)
	Alpha and beta proteins (a+b) (309)
	Artifacts (436)
	All alpha proteins (452)
	All beta proteins (208)
	Coiled coil proteins (11)
	Low resolution protein structures (6)
	Small proteins (11)
	Membrane and cell surface proteins and peptides (5)
	Peptides (4)

AllSelected

1 to 25 of 3,670 Structures

Page 1 of 147

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121P \| pdb_0000121p	Download File View File

STRUKTUR UND GUANOSINTRIPHOSPHAT-HYDROLYSEMECHANISMUS DES C-TERMINAL VERKUERZTEN MENSCHLICHEN KREBSPROTEINS P21-H-RAS

Krengel, U., Scheffzek, K., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.

(1991) Thesis

Released	1994-01-31
Method	X-RAY DIFFRACTION 1.54 Å
Organisms	Homo sapiens
Macromolecule	H-RAS P21 PROTEIN (protein)
Unique Ligands	GCP, MG

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1A2B \| pdb_00001a2b	Download File View File

HUMAN RHOA COMPLEXED WITH GTP ANALOGUE

Ihara, K., Muraguchi, S., Kato, M., Shimizu, T., Shirakawa, M., Kuroda, S., Kaibuchi, K., Hakoshima, T.

(1998) J Biological Chem 273: 9656-9666

Released	1998-06-17
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	TRANSFORMING PROTEIN RHOA (protein)
Unique Ligands	GSP, MG

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1A4R \| pdb_00001a4r	Download File View File

G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM

Rudolph, M.G., Vetter, I.R., Wittinghofer, A.

(1999) Protein Sci 8: 778-787

Released	1999-03-02
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	G25K GTP-BINDING PROTEIN (protein)
Unique Ligands	GDP, GNH, MG

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1AA9 \| pdb_00001aa9	Download File View File

HUMAN C-HA-RAS(1-171)(DOT)GDP, NMR, MINIMIZED AVERAGE STRUCTURE

Ito, Y., Yamasaki, Y., Muto, Y., Kawai, G., Nishimura, S., Miyazawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)

(1997) Biochemistry 36: 9109-9119

Released	1997-07-29
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	C-HA-RAS (protein)
Unique Ligands	GDP, MG

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1AGP \| pdb_00001agp	Download File View File

THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS

Franken, S.M., Scheidig, A.J., Wittinghofer, A., Goody, R.S.

(1993) Biochemistry 32: 8411-8420

Released	1994-04-30
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	C-H-RAS P21 PROTEIN (protein)
Unique Ligands	GNP, MG

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1AGR \| pdb_00001agr	Download File View File

COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4

Tesmer, J.J.G., Sprang, S.R.

(1997) Cell 89: 251-261

Released	1997-06-16
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Rattus norvegicus
Macromolecule	GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) (protein) RGS4 (protein)
Unique Ligands	ALF, CIT, GDP, MG

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1AJE \| pdb_00001aje	Download File View File

CDC42 FROM HUMAN, NMR, 20 STRUCTURES

Feltham, J.L., Dotsch, V., Raza, S., Manor, D., Cerione, R.A., Sutcliffe, M.J., Wagner, G., Oswald, R.E.

(1997) Biochemistry 36: 8755-8766

Released	1997-11-12
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	CDC42HS (protein)

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1AM4 \| pdb_00001am4	Download File View File

COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS)

Rittinger, K., Walker, P., Gamblin, S.J., Smerdon, S.J.

(1997) Nature 388: 693-697

Released	1998-07-15
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	CDC42HS (protein) P50-RHOGAP (protein)
Unique Ligands	GNP, MG

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1AN0 \| pdb_00001an0	Download File View File

CDC42HS-GDP COMPLEX

Kongsaeree, P., Cerione, R., Clardy, J.

To be published

Released	1999-01-13
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	CDC42HS-GDP (protein)
Unique Ligands	GDP, MG

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1AS0 \| pdb_00001as0	Download File View File

GTP-GAMMA-S BOUND G42V GIA1

Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.

(1997) Biochemistry 36: 15660-15669

Released	1997-11-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Rattus norvegicus
Macromolecule	GIA1 (protein)
Unique Ligands	GSP, MG, SO4

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1AS2 \| pdb_00001as2	Download File View File

GDP+PI BOUND G42V GIA1

Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.

(1997) Biochemistry 36: 15660-15669

Released	1997-11-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Rattus norvegicus
Macromolecule	GIA1 (protein)
Unique Ligands	GDP, PO4

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1AS3 \| pdb_00001as3	Download File View File

GDP BOUND G42V GIA1

Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.

(1997) Biochemistry 36: 15660-15669

Released	1997-11-12
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Rattus norvegicus
Macromolecule	GIA1 (protein)
Unique Ligands	GDP, SO4

Explore in 3D

1AZS \| pdb_00001azs	Download File View File

COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE

Tesmer, J.J.G., Sprang, S.R.

(1997) Science 278: 1907-1916

Released	1998-02-25
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Bos taurus Canis lupus familiaris Rattus norvegicus
Macromolecule	GS-ALPHA (protein) IIC2 (protein) VC1 (protein)
Unique Ligands	FKP, GSP, MG

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1AZT \| pdb_00001azt	Download File View File

GS-ALPHA COMPLEXED WITH GTP-GAMMA-S

Tesmer, J.J.G., Sprang, S.R.

(1997) Science 278: 1943-1947

Released	1998-02-25
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Bos taurus
Macromolecule	GS-ALPHA (protein)
Unique Ligands	GSP, MG, PO4

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1BH2 \| pdb_00001bh2	Download File View File

A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT

Mixon, M.B., Posner, B.A., Wall, M.A., Gilman, A.G., Sprang, S.R.

(1998) J Biological Chem 273: 21752-21758

Released	1998-11-04
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Rattus norvegicus
Macromolecule	GUANINE NUCLEOTIDE-BINDING PROTEIN (protein)
Unique Ligands	GSP, MG

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1BKD \| pdb_00001bkd	Download File View File

COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1

Boriack-Sjodin, P.A., Margarit, S.M., Sagi, D.B., Kuriyan, J.

(1998) Nature 394: 337-343

Released	1999-01-13
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	H-RAS (protein) SON OF SEVENLESS-1 (protein)

Explore in 3D

1BOF \| pdb_00001bof	Download File View File

GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM

Coleman, D.E., Sprang, S.R.

(1998) Biochemistry 37: 14376-14385

Released	1999-01-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Rattus norvegicus
Macromolecule	GI ALPHA 1 (protein)
Unique Ligands	GDP, MG, SO4

Explore in 3D

1BYU \| pdb_00001byu	Download File View File

CANINE GDP-RAN

Stewart, M., Kent, H.M., Mccoy, A.J.

(1998) J Mol Biology 284: 1517-1527

Released	1998-12-02
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Canis lupus familiaris
Macromolecule	PROTEIN (GTP-BINDING PROTEIN RAN) (protein)
Unique Ligands	GDP, MG

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1C1Y \| pdb_00001c1y	Download File View File

CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).

Nassar, N.

(1995) Nature 375: 554-560

Released	1999-08-02
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	PROTO-ONCOGENE SERINE/THREONINE PROTEIN KINASE RAF-1 (protein) RAS-RELATED PROTEIN RAP-1A (protein)
Unique Ligands	CA, GTP, MG

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1CC0 \| pdb_00001cc0	Download File View File

CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX

Longenecker, K.L., Read, P., Derewenda, U., Dauter, Z., Garrard, S., Walker, L., Somlyo, A.V., Somlyo, A.P., Nakamoto, R.K., Derewenda, Z.S.

(1999) Acta Crystallogr D Biol Crystallogr 55: 1503-1515

Released	2000-01-07
Method	X-RAY DIFFRACTION 5 Å
Organisms	Homo sapiens
Macromolecule	rho GDP dissociation inhibitor alpha (protein) transforming protein rhoA (protein)
Unique Ligands	GDP, MG

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1CEE \| pdb_00001cee	Download File View File

SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP

Abdul-Manan, N., Aghazadeh, B., Liu, G.A., Majumdar, A., Ouerfelli, O., Rosen, M.K.

(1999) Nature 399: 379-383

Released	1999-06-30
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	GTP-BINDING RHO-LIKE PROTEIN (protein) WISKOTT-ALDRICH SYNDROME PROTEIN WASP (protein)
Unique Ligands	GCP, MG

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1CF4 \| pdb_00001cf4	Download File View File

CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX

Mott, H.R., Owen, D., Nietlispach, D., Lowe, P.N., Lim, L., Laue, E.D.

(1999) Nature 399: 384-388

Released	1999-06-18
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	PROTEIN (ACTIVATED P21CDC42HS KINASE) (protein) PROTEIN (CDC42 HOMOLOG) (protein)
Unique Ligands	GNP, MG

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1CIP \| pdb_00001cip	Download File View File

GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE

Coleman, D., Sprang, S.

(1999) J Biological Chem 274: 16669-16672

Released	1999-04-09
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Rattus norvegicus
Macromolecule	PROTEIN (GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT) (protein)
Unique Ligands	GNP, MG

Explore in 3D

1CJK \| pdb_00001cjk	Download File View File

COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN

Tesmer, J.J.G., Sprang, S.R.

(1999) Science 285: 756-760

Released	1999-08-31
Method	X-RAY DIFFRACTION 3 Å
Organisms	Bos taurus Canis lupus familiaris Rattus norvegicus
Macromolecule	ADENYLATE CYCLASE, TYPE II (protein) ADENYLATE CYCLASE, TYPE V (protein) GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) (protein)
Unique Ligands	CL, FOK, GSP, MES, MG, MN, TAT

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1CJT \| pdb_00001cjt	Download File View File

COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG

Tesmer, J.J.G., Sprang, S.R.

(1999) Science 285: 756-760

Released	1999-08-31
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Bos taurus Canis lupus familiaris Rattus norvegicus
Macromolecule	ADENYLATE CYCLASE, TYPE II (protein) ADENYLATE CYCLASE, TYPE V (protein) GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) (protein)
Unique Ligands	CL, DAD, FOK, GSP, MES, MG, MN

1 to 25 of 3,670 Structures

Page 1 of 147

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

121P | pdb_0000121p

1A2B | pdb_00001a2b

1A4R | pdb_00001a4r

1AA9 | pdb_00001aa9

1AGP | pdb_00001agp

1AGR | pdb_00001agr

1AJE | pdb_00001aje

1AM4 | pdb_00001am4

1AN0 | pdb_00001an0

1AS0 | pdb_00001as0

1AS2 | pdb_00001as2

1AS3 | pdb_00001as3

1AZS | pdb_00001azs

1AZT | pdb_00001azt

1BH2 | pdb_00001bh2

1BKD | pdb_00001bkd

1BOF | pdb_00001bof

1BYU | pdb_00001byu

1C1Y | pdb_00001c1y

1CC0 | pdb_00001cc0

1CEE | pdb_00001cee

1CF4 | pdb_00001cf4

1CIP | pdb_00001cip

1CJK | pdb_00001cjk

1CJT | pdb_00001cjt