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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 5.1.3.14

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Search Summary

This query matches 32 Structures.

Refinements

Structure Determination Methodology

experimental (32)

Scientific Name of Source Organism

	Thermus thermophilus HB27 (10)
	Bacillus anthracis (3)
	Streptomyces kasugaensis (3)
	Escherichia coli (2)
	Methanocaldococcus jannaschii DSM 2661 (2)
	Neisseria meningitidis Z2491 (2)
	Bacillus subtilis (1)
	Bacillus subtilis subsp. subtilis str. 168 (1)
	Burkholderia vietnamiensis G4 (1)
	Homo sapiens (1)

More...

Taxonomy

	Bacteria (29)
	Archaea (2)
	Eukaryota (1)

Experimental Method

X-RAY DIFFRACTION (32)

Polymer Entity Type

Protein (32)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (8)
	2.0 - 2.5 (17)
	2.5 - 3.0 (5)

Release Date

	2000 - 2004 (4)
	2005 - 2009 (3)
	2010 - 2014 (5)
	2015 - 2019 (2)
	2020 - 2024 (18)

Enzyme Classification Name

	Isomerases (32)
	Hydrolases (1)
	Transferases (1)

Symmetry Type

	Cyclic (29)
	Asymmetric (3)
	Dihedral (3)

SCOP Classification

	Alpha and beta proteins (a/b) (14)
	Artifacts (7)

AllSelected

1 to 25 of 32 Structures

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1F6D \| pdb_00001f6d	Download File View File

THE STRUCTURE OF UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE FROM E. COLI.

Campbell, R.E., Mosimann, S.C., Tanner, M.E., Strynadka, N.C.J.

(2000) Biochemistry 39: 14993-15001

Released	2000-12-13
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli
Macromolecule	UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (protein)
Unique Ligands	CL, NA, UDP

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1O6C \| pdb_00001o6c	Download File View File

Crystal structure of UDP-N-acetylglucosamine 2-epimerase

Structural GenomiX

(2005) Proteins 60: 787-796

Released	2003-11-25
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Bacillus subtilis
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)

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1V4V \| pdb_00001v4v	Download File View File

Crystal Structure Of UDP-N-Acetylglucosamine 2-Epimerase From Thermus Thermophilus HB8

Bagautdinov, B., Tahirov, T.H., RIKEN Structural Genomics/Proteomics Initiative (RSGI)

To be published

Released	2003-12-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Thermus thermophilus
Macromolecule	UDP-N-Acetylglucosamine 2-Epimerase (protein)
Unique Ligands	ACY, GOL

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1VGV \| pdb_00001vgv	Download File View File

Crystal structure of UDP-N-acetylglucosamine_2 epimerase

Structural GenomiX

(2005) Proteins 60: 787-796

Released	2003-11-25
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Escherichia coli
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	UD1

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3BEO \| pdb_00003beo	Download File View File

A Structural Basis for the allosteric regulation of non-hydrolyzing UDP-GlcNAc 2-epimerases

Velloso, L.M., Bhaskaran, S.S., Schuch, R., Fischetti, V.A., Stebbins, C.E.

(2008) EMBO Rep 9: 199-205

Released	2008-02-19
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Bacillus anthracis
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	UD1, UDP

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3DZC \| pdb_00003dzc	Download File View File

2.35 Angstrom resolution structure of WecB (VC0917), a UDP-N-acetylglucosamine 2-epimerase from Vibrio cholerae.

Minasov, G., Shuvalova, L., Dubrovska, I., Winsor, J., Papazisi, L., Kwon, K., Hasseman, J., Peterson, S.N., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

To be published

Released	2008-08-12
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Vibrio cholerae
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	CA, CL

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3EO3 \| pdb_00003eo3	Download File View File

Crystal structure of the N-acetylmannosamine kinase domain of human GNE protein

Nedyalkova, L., Tong, Y., Rabeh, W.M., Hong, B., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)

(2009) PLoS One 4: e7165-e7165

Released	2008-10-07
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens
Macromolecule	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (protein)
Unique Ligands	UNX, ZN

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3OT5 \| pdb_00003ot5	Download File View File

2.2 Angstrom Resolution Crystal Structure of putative UDP-N-acetylglucosamine 2-epimerase from Listeria monocytogenes

Minasov, G., Halavaty, A., Shuvalova, L., Dubrovska, I., Winsor, J., Papazisi, L., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

To be published

Released	2010-09-22
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Listeria monocytogenes EGD-e
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	PEG, PGE

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4FKZ \| pdb_00004fkz	Download File View File

Crystal structure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP

Yang, C.S., Chen, S.C., Kuan, S.M., Chen, Y.R., Liu, Y.H., Chen, Y.

To be published

Released	2013-05-08
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Bacillus subtilis subsp. subtilis str. 168
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	UD1, UDP

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4HWG \| pdb_00004hwg	Download File View File

Structure of UDP-N-acetylglucosamine 2-epimerase from Rickettsia bellii

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

To be published

Released	2012-11-28
Method	X-RAY DIFFRACTION 2 Å
Organisms	Rickettsia bellii RML369-C
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	PO4

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4NEQ \| pdb_00004neq	Download File View File

The structure of UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii

Chen, S.C., Yang, C.S., Huang, C.H., Chen, Y.

(2014) Proteins 82: 1519-1526

Released	2014-04-23
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Methanocaldococcus jannaschii DSM 2661
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	TRS

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4NES \| pdb_00004nes	Download File View File

Crystal structure of Methanocaldococcus jannaschii UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP

Chen, S.C., Yang, C.S., Huang, C.H., Chen, Y.

(2014) Proteins 82: 1519-1526

Released	2014-04-23
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Methanocaldococcus jannaschii DSM 2661
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	UD1, UDP

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5DLD \| pdb_00005dld	Download File View File

Crystal Structure of a UDP-N-acetylglucosamine 2-epimerase from Burkholderia vietnamiensis complexed with UDP-GlcNAc and UDP

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

To be published

Released	2015-09-30
Method	X-RAY DIFFRACTION 1.45 Å
Organisms	Burkholderia vietnamiensis G4
Macromolecule	UDP-N-Acetylglucosamine 2-epimerase (protein)
Unique Ligands	ACT, EDO, GOL, NA, UD1, UDP

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5ENZ \| pdb_00005enz	Download File View File

S. aureus MnaA-UDP co-structure

Fischmann, T.O.

(2016) PLoS Pathog 12: e1005585-e1005585

Released	2016-04-27
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Staphylococcus aureus
Macromolecule	UDP-GlcNAc 2-epimerase (protein)
Unique Ligands	PG4, SO4, TRS, UDP

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6VLB \| pdb_00006vlb	Download File View File

Crystal structure of ligand-free UDP-GlcNAc 2-epimerase from Neisseria meningitidis

Fisher, A.J., Hurlburt, N.K.

(2020) Acta Crystallogr F Struct Biol Commun 76: 557-567

Released	2020-11-11
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Neisseria meningitidis Z2491
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	EDO, NA

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6VLC \| pdb_00006vlc	Download File View File

Crystal structure of UDP-GlcNAc 2-epimerase from Neisseria meningitidis bound to UDP-GlcNAc

Fisher, A.J., Hurlburt, N.K.

(2020) Acta Crystallogr F Struct Biol Commun 76: 557-567

Released	2020-11-11
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Neisseria meningitidis Z2491
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	UD1

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7VYY \| pdb_00007vyy	Download File View File

The crystal structure of Non-hydrolyzing UDPGlcNAc 2-epimerase

Li, T.L., Rattinam, R.

(2022) Biomedicines 10:

Released	2022-11-16
Method	X-RAY DIFFRACTION 2.443 Å
Organisms	Streptomyces kasugaensis
Macromolecule	Putative UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	NA

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7VZ6 \| pdb_00007vz6	Download File View File

The crystal structure of Non-hydrolyzing UDPGlcNAc 2-epimerase in complex with UDP-glucose

Li, T.L., Rattinam, R.

(2022) Biomedicines 10:

Released	2022-11-16
Method	X-RAY DIFFRACTION 2.092 Å
Organisms	Streptomyces kasugaensis
Macromolecule	Putative UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	NA, UPG

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7VZA \| pdb_00007vza	Download File View File

The crystal structure of Non-hydrolyzing UDPGlcNAc 2-epimerase in complex with UDP

Li, T.L., Rattinam, R.

(2022) Biomedicines 10:

Released	2022-11-16
Method	X-RAY DIFFRACTION 2.58 Å
Organisms	Streptomyces kasugaensis
Macromolecule	Putative UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	NA, UDP

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8AHE \| pdb_00008ahe	Download File View File

PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery

Baker, L.M., Murray, J.B., Hubbard, R.E.

(2022) RSC Med Chem 13: 1341-1349

Released	2022-09-14
Method	X-RAY DIFFRACTION 2.108 Å
Organisms	Bacillus anthracis
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	M2U, SO4

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8AHF \| pdb_00008ahf	Download File View File

PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery

Baker, L.M., Murray, J.B., Hubbard, R.E.

(2022) RSC Med Chem 13: 1341-1349

Released	2022-09-14
Method	X-RAY DIFFRACTION 2.271 Å
Organisms	Bacillus anthracis
Macromolecule	UDP-N-acetylglucosamine 2-epimerase (protein)
Unique Ligands	M3U, SO4

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8SXV \| pdb_00008sxv	Download File View File

X-ray crystal structure of UDP- 2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase from Thermus thermophilus strain HB27, apo form, pH 9

McKnight, J.O., Thoden, J.B., Holden, H.M.

(2023) J Biological Chem 299: 105200-105200

Released	2023-09-13
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Thermus thermophilus HB27
Macromolecule	UDP-2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase (protein)
Unique Ligands	CL

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8SXW \| pdb_00008sxw	Download File View File

X-ray crystal structure of UDP- 2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase from Thermus thermophilus strain HB27, D98N mutation, apo structure at pH 6

Kroft, C.W., Thoden, J.B., Holden, H.M.

(2023) J Biological Chem 299: 105200-105200

Released	2023-09-13
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Thermus thermophilus HB27
Macromolecule	UDP-2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase (protein)
Unique Ligands	CL, NA

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8SXY \| pdb_00008sxy	Download File View File

X-ray crystal structure of UDP- 2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase from Thermus thermophilus strain HB27 in complex with its product UDP-2,3-diacetamido-2,3-dideoxy-d-mannuronic acid at pH 5

McKnight, J.O., Thoden, J.B., Holden, H.M.

(2023) J Biological Chem 299: 105200-105200

Released	2023-09-13
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Thermus thermophilus HB27
Macromolecule	UDP-2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase (protein)
Unique Ligands	CL, MJ3

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8SY0 \| pdb_00008sy0	Download File View File

X-ray crystal structure of UDP- 2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase from Thermus thermophilus strain HB27 in complex with its product UDP-2,3-diacetamido-2,3-dideoxy-d-mannuronic acid at pH 9

McKnight, J.O., Thoden, J.B., Holden, H.M.

(2023) J Biological Chem 299: 105200-105200

Released	2023-09-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Thermus thermophilus HB27
Macromolecule	UDP-2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase (protein)
Unique Ligands	CL, EDO, MJ3, NA

1 to 25 of 32 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1F6D | pdb_00001f6d

1O6C | pdb_00001o6c

1V4V | pdb_00001v4v

1VGV | pdb_00001vgv

3BEO | pdb_00003beo

3DZC | pdb_00003dzc

3EO3 | pdb_00003eo3

3OT5 | pdb_00003ot5

4FKZ | pdb_00004fkz

4HWG | pdb_00004hwg

4NEQ | pdb_00004neq

4NES | pdb_00004nes

5DLD | pdb_00005dld

5ENZ | pdb_00005enz

6VLB | pdb_00006vlb

6VLC | pdb_00006vlc

7VYY | pdb_00007vyy

7VZ6 | pdb_00007vz6

7VZA | pdb_00007vza

8AHE | pdb_00008ahe

8AHF | pdb_00008ahf

8SXV | pdb_00008sxv

8SXW | pdb_00008sxw

8SXY | pdb_00008sxy

8SY0 | pdb_00008sy0