RCSB PDB: Search

Warning You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.

Help

Help

RCSB PDB

Deposit
- PDBx/mmCIF file
- pdb_extract
- SF-Tool
- Ligand Expo
- MAXIT
- Validation Server
- Validation API
- Information for Journals
- Validation Task Forces
- wwPDB OneDep System
- PDB-IHM
Search
Visualize
Analyze
Download
Learn
- Training Courses
- Guide to PDB Data
- Molecule of the Month
- Educational Resources
- Curricula
- Browse
- News
- SciArt Galleries
- Irving Geis
- David Goodsell
About
Careers
COVID-19

235,183 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

	Include CSM
Advanced Search \| Browse Annotations		Help

Search
Query History
Browse Annotations
MyPDB

QUERY: Chem Comp Monomers (Polymer Entity Container Identifiers) = "TYS"

MyPDB Login

Search API

Advanced Search Query Builder

Help

Full Text

Structure Attributes

Help

NOT

Count

Add Subquery

Chemical Attributes

Sequence Similarity

Sequence Motif

Structure Similarity

Structure Motif

Chemical Similarity

Return

grouped by

Include Computed Structure Models (CSM)

Count

Clear

Search Summary

This query matches 345 Structures.

Refinements

Structure Determination Methodology

experimental (345)

Scientific Name of Source Organism

	Homo sapiens (332)
	Hirudo medicinalis (237)
	Human immunodeficiency virus 1 (28)
	synthetic construct (8)
	Glossina morsitans morsitans (6)
	Mus musculus (6)
	Arabidopsis (4)
	Arabidopsis thaliana (4)
	Macaca mulatta (4)
	Conus anemone (2)

More...

Taxonomy

	Eukaryota (344)
	Riboviria (30)
	Eukaryota (eukaryotes) (17)
	other sequences (8)
	Bacteria (4)

Experimental Method

	X-RAY DIFFRACTION (294)
	ELECTRON MICROSCOPY (39)
	SOLUTION NMR (12)

Polymer Entity Type

Protein (345)

Refinement Resolution (Å)

	1.0 - 1.5 (56)
	1.5 - 2.0 (124)
	2.0 - 2.5 (81)
	2.5 - 3.0 (29)
	3.0 - 3.5 (23)
	3.5 - 4.0 (13)
	4.0 - 4.5 (3)
	> 4.5 (4)

Release Date

	1990 - 1994 (6)
	1995 - 1999 (29)
	2000 - 2004 (54)
	2005 - 2009 (71)
	2010 - 2014 (52)
	2015 - 2019 (50)
	2020 - 2024 (80)
	2025 - 2029 (3)

Enzyme Classification Name

	Hydrolases (267)
	Transferases (5)
	Lyases (2)

Membrane Protein Annotation

	PDBTM (15)
	OPM (13)
	mpstruc (12)
	MemProtMD (7)

Symmetry Type

	Asymmetric (343)
	Cyclic (4)

SCOP Classification

	All beta proteins (115)
	Small proteins (5)
	Alpha and beta proteins (a+b) (3)
	Alpha and beta proteins (a/b) (3)
	Artifacts (3)
	Multi-domain proteins (alpha and beta) (1)

AllSelected

1 to 25 of 345 Structures

Page 1 of 14

Sort by

Explore in 3D

1A2C \| pdb_00001a2c	Download File View File

Structure of thrombin inhibited by AERUGINOSIN298-A from a BLUE-GREEN ALGA

Rios-Steiner, J.L., Murakami, M., Tulinsky, A.

(1998) J Am Chem Soc 120: 597

Released	1998-07-01
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens Microcystis aeruginosa
Macromolecule	Aeruginosin 298-A (protein) Hirudin variant-2 (protein) Thrombin heavy chain (protein) Thrombin light chain (protein)
Unique Ligands	NA

Explore in 3D

1A46 \| pdb_00001a46	Download File View File

THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR

St Charles, R., Matthews, J.H., Zhang, E., Tulinsky, A., Kahn, M.

(1999) J Med Chem 42: 1376-1383

Released	1998-05-27
Method	X-RAY DIFFRACTION 2.12 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	00K, NA

Explore in 3D

1A4W \| pdb_00001a4w	Download File View File

CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE

Matthews, J.H., Krishnan, R., Costanzo, M.J., Maryanoff, B.E., Tulinsky, A.

(1996) Biophys J 71: 2830-2839

Released	1998-04-29
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	NA, QWE

Explore in 3D

1A5G \| pdb_00001a5g	Download File View File

HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN

St Charles, R., Tulinsky, A., Kahn, M.

(1999) J Med Chem 42: 1376-1383

Released	1998-05-27
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	00L, NA

Explore in 3D

1A61 \| pdb_00001a61	Download File View File

THROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR

St Charles, R., Matthews, J.H., Zhang, E., Tulinsky, A., Kahn, M.

(1999) J Med Chem 42: 1376-1383

Released	1998-06-17
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	00N, NA

Explore in 3D

1AD8 \| pdb_00001ad8	Download File View File

COMPLEX OF THROMBIN WITH AND INHIBITOR CONTAINING A NOVEL P1 MOIETY

Schreuder, H., Tardif, C., Malikayil, J.A.

(1997) Biochemistry 36: 1034-1040

Released	1997-11-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUDIN (53-65) PEPTIDE (protein) THROMBIN (LARGE SUBUNIT) (protein) THROMBIN (SMALL SUBUNIT) (protein)
Unique Ligands	MDL, NA

Explore in 3D

1AE8 \| pdb_00001ae8	Download File View File

HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP

De Simone, G., Balliano, G., Milla, P., Gallina, C., Giordano, C., Tarricone, C., Rizzi, M., Bolognesi, M., Ascenzi, P.

(1997) J Mol Biology 269: 558-569

Released	1997-12-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	AZL, NAG

Explore in 3D

1AFE \| pdb_00001afe	Download File View File

HUMAN ALPHA-THROMBIN INHIBITION BY CBZ-PRO-AZALYS-ONP

De Simone, G., Balliano, G., Milla, P., Gallina, C., Giordano, C., Tarricone, C., Rizzi, M., Bolognesi, M., Ascenzi, P.

(1997) J Mol Biology 269: 558-569

Released	1997-12-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	ALZ, NAG

Explore in 3D

1AHT \| pdb_00001aht	Download File View File

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROMS RESOLUTION

Chen, Z.

(1995) Arch Biochem Biophys 322: 198-203

Released	1996-03-17
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	APA

Explore in 3D

1AI8 \| pdb_00001ai8	Download File View File

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG

Skordalakes, E., Dodson, G., Elgendy, S., Goodwin, C.A., Green, D., Tyrrel, R., Scully, M.F., Freyssinet, J., Kakkar, V.V., Deadman, J.

(1992) Protein Sci 1: 426-471

Released	1997-10-15
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUDIN IIIB (protein)
Unique Ligands	T42

Explore in 3D

1AIX \| pdb_00001aix	Download File View File

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL

Skordalakes, E., Dodson, G., Elgendy, S., Goodwin, C.A., Green, D., Tyrrel, R., Scully, M.F., Freyssinet, J., Kakkar, V.V., Deadman, J.

(1992) Protein Sci 1: 426-471

Released	1997-10-15
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	T19

Explore in 3D

1AWF \| pdb_00001awf	Download File View File

NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT

Jhoti, H., Cleasby, A., Wonacott, A.

(1998) Biochemistry 37: 6645-6657

Released	1998-10-28
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA THROMBIN (protein) HIRUGEN (protein)
Unique Ligands	GR4

Explore in 3D

1AY6 \| pdb_00001ay6	Download File View File

THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF

Ganesh, V., Maryanoff, B.E., Tulinsky, A.

(1996) Bioorg Med Chem Lett 6: 2947-2952

Released	1998-03-18
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN HEAVY CHAIN (protein) THROMBIN LIGHT CHAIN (protein)
Unique Ligands	1ZV

Explore in 3D

1B5G \| pdb_00001b5g	Download File View File

HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN

St Charles, R., Tulinsky, A., Kahn, M.

(1999) J Med Chem 42: 1376-1383

Released	1998-05-27
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (protein) HIRUGEN (protein)
Unique Ligands	0ZE, NA

Explore in 3D

1BA8 \| pdb_00001ba8	Download File View File

THROMBIN INHIBITOR WITH A RIGID TRIPEPTIDYL ALDEHYDES

Krishnan, R., Zhang, E., Hakansson, K., Arni, R.K., Tulinsky, A., Lim-Wilby, M.S.L., Levy, O.E., Semple, J.E., Brunck, T.K.

(1998) Biochemistry 37: 12094-12103

Released	1999-04-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN (protein)
Unique Ligands	0IT, NAG

Explore in 3D

1BB0 \| pdb_00001bb0	Download File View File

THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES

Krishnan, R., Zhang, E., Hakansson, K., Arni, R.K., Tulinsky, A., Lim-Wilby, M.S.L., Levy, O.E., Semple, J.E., Brunck, T.K.

(1998) Biochemistry 37: 12094-12103

Released	1999-04-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN (protein)
Unique Ligands	0IV, NA

Explore in 3D

1BCU \| pdb_00001bcu	Download File View File

ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND PROFLAVIN

Conti, E., Rivetti, C., Wonacott, A., Brick, P.

(1998) FEBS Lett 425: 229-233

Released	1998-10-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (protein) HIRUGEN (protein)
Unique Ligands	PRL

Explore in 3D

1C1U \| pdb_00001c1u	Download File View File

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES

Katz, B.A., Luong, C.

(1998) Nature 391: 608-612

Released	2000-07-26
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ACETYL HIRUDIN (protein) ALPHA THROMBIN (protein)
Unique Ligands	BAI, NA, ZN

Explore in 3D

1C1V \| pdb_00001c1v	Download File View File

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES

Katz, B.A., Luong, C.

(1998) Nature 391: 608-612

Released	2000-07-26
Method	X-RAY DIFFRACTION 1.98 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	Hirudin-2 (protein) Thrombin heavy chain (protein) Thrombin light chain (protein)
Unique Ligands	BAB, NA, ZN

Explore in 3D

1C1W \| pdb_00001c1w	Download File View File

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES

Katz, B.A., Luong, C.

(1998) Nature 391: 608-612

Released	2000-07-26
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	Hirudin-2 (protein) Thrombin heavy chain (protein) Thrombin light chain (protein)
Unique Ligands	BAH, NA, ZN

Explore in 3D

1C4U \| pdb_00001c4u	Download File View File

SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-09-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	PROTEIN (HIRUGEN) (protein) thrombin (protein)
Unique Ligands	IH1, NA

Explore in 3D

1C4V \| pdb_00001c4v	Download File View File

SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-09-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN:LONG CHAIN (protein) THROMBIN:SHORT CHAIN (protein)
Unique Ligands	IH2, NA

Explore in 3D

1C4Y \| pdb_00001c4y	Download File View File

SELECTIVE NON-ELECTROPHILIC THROMBIN INHIBITORS

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-10-09
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN:LONG CHAIN (protein) THROMBIN:SHORT CHAIN (protein)
Unique Ligands	IH3

Explore in 3D

1C5L \| pdb_00001c5l	Download File View File

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.

(2000) Chem Biol 7: 299-312

Released	2000-12-22
Method	X-RAY DIFFRACTION 1.47 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	Hirudin (protein) thrombin (protein)
Unique Ligands	CA, NA

Explore in 3D

1C5N \| pdb_00001c5n	Download File View File

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.

(2000) Chem Biol 7: 299-312

Released	2000-12-22
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	Hirudin (protein) Thrombin heavy chain (protein) Thrombin light chain (protein)
Unique Ligands	CA, ESI, NA

1 to 25 of 345 Structures

Page 1 of 14

Sort by

About
About Us
Citing Us
Publications
Team
Careers
Usage & Privacy

Support
Contact Us
Help
Website FAQ
Glossary
Service Status

RCSB PDB is hosted by

RCSB PDB is a member of the

RCSB Partners
Nucleic Acid Knowledgebase

wwPDB Partners
RCSB PDB
PDBe
PDBj
BMRB
EMDB

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

Prepare Data

Validate Data

Deposit Data

Help and Resources

Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1A2C | pdb_00001a2c

1A46 | pdb_00001a46

1A4W | pdb_00001a4w

1A5G | pdb_00001a5g

1A61 | pdb_00001a61

1AD8 | pdb_00001ad8

1AE8 | pdb_00001ae8

1AFE | pdb_00001afe

1AHT | pdb_00001aht

1AI8 | pdb_00001ai8

1AIX | pdb_00001aix

1AWF | pdb_00001awf

1AY6 | pdb_00001ay6

1B5G | pdb_00001b5g

1BA8 | pdb_00001ba8

1BB0 | pdb_00001bb0

1BCU | pdb_00001bcu

1C1U | pdb_00001c1u

1C1V | pdb_00001c1v

1C1W | pdb_00001c1w

1C4U | pdb_00001c4u

1C4V | pdb_00001c4v

1C4Y | pdb_00001c4y

1C5L | pdb_00001c5l

1C5N | pdb_00001c5n