RCSB PDB: Search

1KSW \| pdb_00001ksw	Download File View File

Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP

Witucki, L.A., Huang, X., Shah, K., Liu, Y., Kyin, S., Eck, M.J., Shokat, K.M.

(2002) Chem Biol 9: 25-33

Released	2002-02-27
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (protein)
Unique Ligands	NBS

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1WMA \| pdb_00001wma	Download File View File

Crystal structure of human CBR1 in complex with Hydroxy-PP

Rauh, D., Bateman, R., Shokat, K.M.

(2005) PLoS Biol 3: 128-128

Released	2005-04-26
Method	X-RAY DIFFRACTION 1.24 Å
Organisms	Homo sapiens
Macromolecule	Carbonyl reductase [NADPH] 1 (protein)
Unique Ligands	AB3, NDP, P33, PE5, SO4

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2CHW \| pdb_00002chw	Download File View File

A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39

Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.

(2006) Cell 125: 733

Released	2006-05-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (protein)
Unique Ligands	039

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2CHX \| pdb_00002chx	Download File View File

A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90

Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.

(2006) Cell 125: 733

Released	2006-05-22
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (protein)
Unique Ligands	090

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2CHZ \| pdb_00002chz	Download File View File

A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93

Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.

(2006) Cell 125: 733

Released	2006-05-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (protein)
Unique Ligands	093

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2HOS \| pdb_00002hos	Download File View File

Phage-Selected Homeodomain Bound to Unmodified DNA

Shokat, K.M., Feldman, M.E., Simon, M.D.

(2006) ACS Chem Biol 1: 755-760

Released	2006-12-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Drosophila melanogaster
Macromolecule	Segmentation polarity homeobox protein engrailed (protein) 5'-D(APTPCPCPGPGPGPGPAPTPTPAPCPAPTPGPGPCPAPAPA)-3' (nucleic acid) 5'-D(TPTPTPTPGPCPCPAPTPGPTPAPAPTPCPCPCPCPGPGPA)-3' (nucleic acid)
Unique Ligands	3MO, GOL

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2HOT \| pdb_00002hot	Download File View File

Phage selected homeodomain bound to modified DNA

Feldman, M.E., Simon, M.D., Shokat, K.M.

(2006) ACS Chem Biol 1: 755-760

Released	2006-12-12
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Drosophila melanogaster
Macromolecule	Segmentation polarity homeobox protein engrailed (protein) 5'-D(APTPCPCPGPGPGPGPAPTPTPAPCPAPTPGPGPCPAPAPA)-3' (nucleic acid) 5'-D(TPTPTPTPGPCPCPAPTPGPTPAPAPTPCPCPCPCPGPGPA)-3' (nucleic acid)
Unique Ligands	GOL, P2O

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2HWO \| pdb_00002hwo	Download File View File

Crystal structure of Src kinase domain in complex with covalent inhibitor

Rauh, D., Blair, J.A., Shokat, K.M.

(2007) Nat Chem Biol 3: 229-238

Released	2007-02-27
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Gallus gallus
Macromolecule	Proto-oncogene tyrosine-protein kinase Src (protein)
Unique Ligands	GOL, RBS

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2HWP \| pdb_00002hwp	Download File View File

Crystal structure of Src kinase domain in complex with covalent inhibitor PD168393

Rauh, D., Blair, J.A., Shokat, K.M.

(2007) Nat Chem Biol 3: 229-238

Released	2007-02-27
Method	X-RAY DIFFRACTION 2.48 Å
Organisms	Gallus gallus
Macromolecule	Proto-oncogene tyrosine-protein kinase Src (protein)
Unique Ligands	DJK

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2PFG \| pdb_00002pfg	Download File View File

Crystal structure of human CBR1 in complex with BiGF2.

Rauh, D., Bateman, R.L., Shokat, K.M.

(2007) Org Biomol Chem 5: 3363-3367

Released	2007-09-25
Method	X-RAY DIFFRACTION 1.54 Å
Organisms	Homo sapiens
Macromolecule	Carbonyl reductase [NADPH] 1 (protein)
Unique Ligands	CL, DDD, GOL, NAP

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2V4L \| pdb_00002v4l	Download File View File

complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284

Apsel, B., Gonzalez, B., Blair, J.A., Nazif, T.M., Feldman, M.E., Williams, R.L., Shokat, K.M., Knight, Z.A.

(2008) Nat Chem Biol 4: 691

Released	2008-10-14
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (protein)
Unique Ligands	ABJ

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2WEI \| pdb_00002wei	Download File View File

Crystal structure of the kinase domain of Cryptosporidium parvum calcium dependent protein kinase in complex with 3-MB-PP1

Roos, A.K., King, O., Chaikuad, A., Zhang, C., Shokat, K.M., Wernimont, A.K., Artz, J.D., Lin, L., MacKenzie, F.I., Finerty, P.J., Vedadi, M., Schapira, M., Indarte, M., Kozieradzki, I., Pike, A.C.W., Fedorov, O., Doyle, D., Muniz, J., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., von Delft, F., Heightman, T., Hui, R.

(2011) BMC Genomics 12: 478

Released	2009-04-28
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Cryptosporidium parvum Iowa II
Macromolecule	CALMODULIN-DOMAIN PROTEIN KINASE 1, PUTATIVE (protein)
Unique Ligands	VGG

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2WXF \| pdb_00002wxf	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	039

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2WXG \| pdb_00002wxg	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZN

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2WXH \| pdb_00002wxh	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZO

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2WXI \| pdb_00002wxi	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	GOL, S30

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2WXJ \| pdb_00002wxj	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	RW3

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2WXK \| pdb_00002wxk	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	RW4

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2WXL \| pdb_00002wxl	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZS4

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2WXM \| pdb_00002wxm	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZM

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2WXN \| pdb_00002wxn	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	DLN

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2WXO \| pdb_00002wxo	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZP

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2WXP \| pdb_00002wxp	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	GD9

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2WXQ \| pdb_00002wxq	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)
Unique Ligands	ZZQ

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2WXR \| pdb_00002wxr	Download File View File

The crystal structure of the murine class IA PI 3-kinase p110delta.

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

(2010) Nat Chem Biol 6: 117

Released	2010-01-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Mus musculus
Macromolecule	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (protein)

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1KSW | pdb_00001ksw

1WMA | pdb_00001wma

2CHW | pdb_00002chw

2CHX | pdb_00002chx

2CHZ | pdb_00002chz

2HOS | pdb_00002hos

2HOT | pdb_00002hot

2HWO | pdb_00002hwo

2HWP | pdb_00002hwp

2PFG | pdb_00002pfg

2V4L | pdb_00002v4l

2WEI | pdb_00002wei

2WXF | pdb_00002wxf

2WXG | pdb_00002wxg

2WXH | pdb_00002wxh

2WXI | pdb_00002wxi

2WXJ | pdb_00002wxj

2WXK | pdb_00002wxk

2WXL | pdb_00002wxl

2WXM | pdb_00002wxm

2WXN | pdb_00002wxn

2WXO | pdb_00002wxo

2WXP | pdb_00002wxp

2WXQ | pdb_00002wxq

2WXR | pdb_00002wxr