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235,183 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Keywords HAS EXACT PHRASE "CHAPERONE/HYDROLASE"

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Search Summary

This query matches 51 Structures.

Refinements

Structure Determination Methodology

experimental (51)

Scientific Name of Source Organism

	Homo sapiens (27)
	Escherichia coli K-12 (18)
	Escherichia coli (6)
	Escherichia coli O157:H7 (4)
	Thermus thermophilus HB8 (4)
	Bacillus subtilis (1)
	Escherichia coli 55989 (1)
	Haemophilus influenzae (1)
	Haemophilus influenzae Rd KW20 (1)
	Mycobacterium kansasii ATCC 12478 (1)

More...

Taxonomy

	Eukaryota (29)
	Bacteria (28)
	Duplodnaviria (1)

Experimental Method

	X-RAY DIFFRACTION (28)
	ELECTRON MICROSCOPY (14)
	SOLUTION NMR (9)

Polymer Entity Type

Protein (51)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (12)
	2.0 - 2.5 (5)
	2.5 - 3.0 (5)
	3.0 - 3.5 (7)
	3.5 - 4.0 (4)
	4.0 - 4.5 (2)
	> 4.5 (6)

Release Date

	2000 - 2004 (6)
	2005 - 2009 (3)
	2010 - 2014 (1)
	2015 - 2019 (12)
	2020 - 2024 (29)

Enzyme Classification Name

	Hydrolases (50)
	Lyases (2)

Symmetry Type

	Asymmetric (34)
	Cyclic (8)
	Dihedral (7)
	Icosahedral (1)
	Octahedral (1)
	Tetrahedral (1)

SCOP Classification

	Alpha and beta proteins (a+b) (11)
	Alpha and beta proteins (a/b) (8)

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1 to 25 of 51 Structures

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1G3I \| pdb_00001g3i	Download File View File

CRYSTAL STRUCTURE OF THE HSLUV PROTEASE-CHAPERONE COMPLEX

Sousa, M.C., Trame, C.B., Tsuruta, H., Wilbanks, S.M., Reddy, V.S., McKay, D.B.

(2000) Cell 103: 633-643

Released	2000-11-22
Method	X-RAY DIFFRACTION 3.41 Å
Organisms	Haemophilus influenzae
Macromolecule	ATP-DEPENDENT HSLU PROTEASE ATP-BINDING SUBUNIT HSLU (protein) ATP-DEPENDENT PROTEASE HSLV (protein)
Unique Ligands	ATP

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1G4A \| pdb_00001g4a	Download File View File

CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM

Wang, J., Song, J.J., Franklin, M.C., Kamtekar, S., Im, Y.J., Rho, S.H., Seong, I.S., Lee, C.S., Chung, C.H., Eom, S.H.

(2001) Structure 9: 177-184

Released	2001-02-21
Method	X-RAY DIFFRACTION 3 Å
Organisms	Escherichia coli
Macromolecule	ATP-DEPENDENT HSL PROTEASE ATP-BINDING SUBUNIT HSLU (protein) ATP-DEPENDENT PROTEASE HSLV (protein)
Unique Ligands	DAT

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1G4B \| pdb_00001g4b	Download File View File

CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM

Wang, J., Song, J.J., Franklin, M.C., Kamtekar, S., Im, Y.J., Rho, S.H., Seong, I.S., Lee, C.S., Chung, C.H., Eom, S.H.

(2001) Structure 9: 177-184

Released	2001-02-21
Method	X-RAY DIFFRACTION 7 Å
Organisms	Escherichia coli
Macromolecule	ATP-DEPENDENT HSL PROTEASE ATP-BINDING SUBUNIT HSLU (protein) ATP-DEPENDENT PROTEASE HSLV (protein)

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1IZY \| pdb_00001izy	Download File View File

Crystal structure of Hsp31

Cha, S.S., Lee, S.J.

(2003) J Biological Chem 278: 44552-44559

Released	2003-10-16
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Escherichia coli
Macromolecule	Hsp31 (protein)

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1IZZ \| pdb_00001izz	Download File View File

Crystal structure of Hsp31

Cha, S.S., Lee, S.J.

(2003) J Biological Chem 278: 44552-44559

Released	2003-10-16
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Escherichia coli
Macromolecule	Hsp31 (protein)

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1KYI \| pdb_00001kyi	Download File View File

HslUV (H. influenzae)-NLVS Vinyl Sulfone Inhibitor Complex

Sousa, M.C., Kessler, B.M., Overkleeft, H.S., McKay, D.B.

(2002) J Mol Biology 318: 779-785

Released	2002-05-15
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Haemophilus influenzae Rd KW20
Macromolecule	ATP-dependent hsl protease ATP-binding subunit hslU (protein) ATP-dependent protease hslV (protein)
Unique Ligands	ATP, LVS

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1YYF \| pdb_00001yyf	Download File View File

Correction of X-ray Intensities from an HslV-HslU co-crystal containing lattice translocation defects

Wang, J., Rho, S.H., Park, H.H., Eom, S.H.

(2005) Acta Crystallogr D Biol Crystallogr 61: 932-941

Released	2005-07-12
Method	X-RAY DIFFRACTION 4.16 Å
Organisms	Bacillus subtilis Escherichia coli
Macromolecule	ATP-dependent hsl protease ATP-binding subunit hslU (protein) ATP-dependent protease hslV (protein)
Unique Ligands	ADP

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2GQ0 \| pdb_00002gq0	Download File View File

Crystal Structure of the Middle Domain of HtpG, the E. coli Hsp90

Harris, S.F., Shiau, A.K., Agard, D.A.

(2006) Cell 127: 329-340

Released	2006-10-31
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Escherichia coli
Macromolecule	Chaperone protein htpG (protein)

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2Z5C \| pdb_00002z5c	Download File View File

Crystal Structure of a Novel Chaperone Complex for Yeast 20S Proteasome Assembly

Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano, Y., Murata, S., Kato, K., Yamane, T., Tanaka, K.

(2008) Nat Struct Mol Biol 15: 228-236

Released	2008-01-22
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Proteasome component PUP2 (protein) Protein YPL144W (protein) Uncharacterized protein YLR021W (protein)

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4JPO \| pdb_00004jpo	Download File View File

5A resolution structure of Proteasome Assembly Chaperone Hsm3 in complex with a C-terminal fragment of Rpt1

Lovell, S., Battaile, K.P., Singh, R., Roelofs, J.

(2013) Nature 497: 512-516

Released	2013-04-10
Method	X-RAY DIFFRACTION 5 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	26S protease regulatory subunit 7 homolog (protein) DNA mismatch repair protein HSM3 (protein)

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5JTL \| pdb_00005jtl	Download File View File

The structure of chaperone SecB in complex with unstructured proPhoA

Huang, C., Saio, T., Rossi, P., Kalodimos, C.G.

(2016) Nature 537: 202-206

Released	2016-08-24
Method	SOLUTION NMR
Organisms	Escherichia coli K-12 Escherichia coli O157:H7
Macromolecule	Alkaline phosphatase (protein) Protein-export protein SecB (protein)

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5JTM \| pdb_00005jtm	Download File View File

The structure of chaperone SecB in complex with unstructured PhoA binding site a

Huang, C., Saio, T., Rossi, P., Kalodimos, C.G.

(2016) Nature 537: 202-206

Released	2016-08-24
Method	SOLUTION NMR
Organisms	Escherichia coli 55989 Escherichia coli K-12
Macromolecule	Alkaline phosphatase (protein) Protein-export protein SecB (protein)

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5JTN \| pdb_00005jtn	Download File View File

The structure of chaperone SecB in complex with unstructured proPhoA binding site c

Huang, C., Saio, T., Rossi, P., Kalodimos, C.G.

(2016) Nature 537: 202-206

Released	2016-08-24
Method	SOLUTION NMR
Organisms	Escherichia coli K-12 Escherichia coli O157:H7
Macromolecule	Alkaline phosphatase (protein) Protein-export protein SecB (protein)

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5JTO \| pdb_00005jto	Download File View File

The structure of chaperone SecB in complex with unstructured proPhoA binding site d

Huang, C., Saio, T., Rossi, P., Kalodimos, C.G.

(2016) Nature 537: 202-206

Released	2016-08-24
Method	SOLUTION NMR
Organisms	Escherichia coli K-12 Escherichia coli O157:H7
Macromolecule	Alkaline phosphatase (protein) Protein-export protein SecB (protein)

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5JTP \| pdb_00005jtp	Download File View File

The structure of chaperone SecB in complex with unstructured proPhoA binding site e

Huang, C., Saio, T., Rossi, P., Kalodimos, C.G.

(2016) Nature 537: 202-206

Released	2016-08-24
Method	SOLUTION NMR
Organisms	Escherichia coli K-12 Escherichia coli O157:H7
Macromolecule	Alkaline phosphatase (protein) Protein-export protein SecB (protein)

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5VBA \| pdb_00005vba	Download File View File

Structure of EspG1 chaperone from the type VII (ESX-1) secretion system determined with the assistance of N-terminal T4 lysozyme fusion

Korotkov, K.V.

(2019) J Mol Biology 431: 289-307

Released	2017-07-05
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Mycobacterium kansasii ATCC 12478 Tequatrovirus T4
Macromolecule	Lysozyme, ESX-1 secretion-associated protein EspG1 chimera (protein)
Unique Ligands	CL

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6DO2 \| pdb_00006do2	Download File View File

Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine

Ferrie, R.P., Chen, Y., Antoshchenko, T., Cooney, O.M., Huang, Y., Park, H.W.

To be published

Released	2019-06-12
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Endoplasmic reticulum chaperone BiP (protein)
Unique Ligands	H5V

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6MCK \| pdb_00006mck	Download File View File

p97 D1D2 with CB5083 bound

Xia, D., Tang, W.K.

(2019) Mol Pharmacol 95: 286-293

Released	2019-01-23
Method	X-RAY DIFFRACTION 3.77 Å
Organisms	Homo sapiens
Macromolecule	Transitional endoplasmic reticulum ATPase (protein)
Unique Ligands	JDP

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6PRI \| pdb_00006pri	Download File View File

Structural Basis for Client Recognition and Activity of Hsp40 Chaperones

Jiang, Y., Rossi, P., Kalodimos, C.G.

(2019) Science 365: 1313-1319

Released	2019-09-18
Method	SOLUTION NMR
Organisms	Escherichia coli K-12 Thermus thermophilus HB8
Macromolecule	Alkaline phosphatase,Chaperone protein DnaJ 2 (protein)

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6PRJ \| pdb_00006prj	Download File View File

Structural Basis for Client Recognition and Activity of Hsp40 Chaperones

Jiang, Y., Rossi, P., Kalodimos, C.G.

(2019) Science 365: 1313-1319

Released	2019-09-18
Method	SOLUTION NMR
Organisms	Escherichia coli K-12 Thermus thermophilus HB8
Macromolecule	Alkaline phosphatase,Chaperone protein DnaJ 2 fusion (protein)

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6PRP \| pdb_00006prp	Download File View File

Structural Basis for Client Recognition and Activity of Hsp40 Chaperones

Jiang, Y., Rossi, P., Kalodimos, C.G.

(2019) Science 365: 1313-1319

Released	2019-09-18
Method	SOLUTION NMR
Organisms	Thermus thermophilus Thermus thermophilus HB8
Macromolecule	Chaperone protein DnaK, Chaperone protein DnaJ 2 fusion (protein)

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6PRQ \| pdb_00006prq	Download File View File

Structural Basis for Client Recognition and Activity of Hsp40 Chaperones

Jiang, Y., Rossi, P., Kalodimos, C.G.

(2019) Science 365: 1313-1319

Released	2019-09-18
Method	SOLUTION NMR
Organisms	Escherichia coli K-12 Thermus thermophilus HB8
Macromolecule	Alkaline phosphatase,Chaperone protein DnaJ 2 fusion (protein)

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7N6J \| pdb_00007n6j	Download File View File

Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RKQSTIALALLPLLFTPRR

Jansen, R.M., Ozden, C., Gierasch, L.M., Garman, S.C.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-06-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli K-12
Macromolecule	Alkaline phosphatase peptide (protein) Chaperone protein DnaK (protein)
Unique Ligands	SO4

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7N6K \| pdb_00007n6k	Download File View File

Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RALALLPLSR

Jansen, R.M., Ozden, C., Gierasch, L.M., Garman, S.C.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-06-23
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Escherichia coli K-12
Macromolecule	Alkaline phosphatase peptide (protein) Chaperone protein DnaK (protein)
Unique Ligands	SO4

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7N6L \| pdb_00007n6l	Download File View File

Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide EANQQKPLLGLFADG

Jansen, R.M., Ozden, C., Gierasch, L.M., Garman, S.C.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-06-23
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Escherichia coli K-12
Macromolecule	Alkaline phosphatase peptide (protein) Chaperone protein DnaK (protein)
Unique Ligands	GOL, SO4

1 to 25 of 51 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1G3I | pdb_00001g3i

1G4A | pdb_00001g4a

1G4B | pdb_00001g4b

1IZY | pdb_00001izy

1IZZ | pdb_00001izz

1KYI | pdb_00001kyi

1YYF | pdb_00001yyf

2GQ0 | pdb_00002gq0

2Z5C | pdb_00002z5c

4JPO | pdb_00004jpo

5JTL | pdb_00005jtl

5JTM | pdb_00005jtm

5JTN | pdb_00005jtn

5JTO | pdb_00005jto

5JTP | pdb_00005jtp

5VBA | pdb_00005vba

6DO2 | pdb_00006do2

6MCK | pdb_00006mck

6PRI | pdb_00006pri

6PRJ | pdb_00006prj

6PRP | pdb_00006prp

6PRQ | pdb_00006prq

7N6J | pdb_00007n6j

7N6K | pdb_00007n6k

7N6L | pdb_00007n6l