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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Keywords HAS EXACT PHRASE "DNA/ANTIBIOTIC"

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Search Summary

This query matches 68 Structures.

Refinements

Structure Determination Methodology

experimental (68)

Scientific Name of Source Organism

	synthetic construct (32)
	Streptomyces antibioticus (14)
	Streptomyces echinatus (8)
	Bacillus cereus (5)
	Streptomyces sp. (5)
	Mycobacterium tuberculosis (4)
	Mycolicibacterium smegmatis MC2 155 (4)
	Streptomyces (4)
	Bacillus subtilis (3)
	Streptococcus pneumoniae (3)

More...

Taxonomy

	Bacteria (56)
	other sequences (32)
	Eukaryota (1)

Experimental Method

	X-RAY DIFFRACTION (54)
	SOLUTION NMR (8)
	ELECTRON MICROSCOPY (6)

Polymer Entity Type

	DNA (68)
	Protein (57)

Refinement Resolution (Å)

	1.0 - 1.5 (8)
	1.5 - 2.0 (15)
	2.0 - 2.5 (8)
	2.5 - 3.0 (12)
	3.0 - 3.5 (16)
	3.5 - 4.0 (1)

Release Date

	1990 - 1994 (2)
	1995 - 1999 (8)
	2000 - 2004 (7)
	2005 - 2009 (6)
	2010 - 2014 (11)
	2015 - 2019 (17)
	2020 - 2024 (16)
	2025 - 2029 (1)

Enzyme Classification Name

	Transferases (11)
	Isomerases (6)

Symmetry Type

	Asymmetric (32)
	Cyclic (25)

SCOP Classification

	Multi-domain proteins (alpha and beta) (2)
	All alpha proteins (1)
	Alpha and beta proteins (a+b) (1)

AllSelected

1 to 25 of 68 Structures

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173D \| pdb_0000173d	Download File View File

MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA

Kamitori, S., Takusagawa, F.

(1994) J Am Chem Soc 116: 4154

Released	1994-10-15
Method	X-RAY DIFFRACTION 3 Å
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) DNA (5'-D(GPAPAPGPCPTPTPC)-3') (nucleic acid)

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185D \| pdb_0000185d	Download File View File

SEQUENCE SPECIFICITY OF QUINOXALINE ANTIBIOTICS. 1. SOLUTION STRUCTURE OF A 1:1 COMPLEX BETWEEN TRIOSTIN A AND [D(GACGTC)]2 AND COMPARISON WITH THE SOLUTION STRUCTURE OF THE [N-MECYS3, N-MECYS7]TANDEM-[D(GATATC)]2 COMPLEX

Addess, K.J., Feigon, J.

(1994) Biochemistry 33: 12386

Released	1995-02-07
Method	SOLUTION NMR
Organisms	Streptomyces sp.
Macromolecule	TRIOSTIN A (protein) DNA (5'-D(GPAPCPGPTPC)-3') (nucleic acid)
Unique Ligands	QUI

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193D \| pdb_0000193d	Download File View File

SOLUTION STRUCTURE OF A QUINOMYCIN BISINTERCALATOR-DNA COMPLEX

Chen, H., Patel, D.J.

(1995) J Mol Biology 246: 164

Released	1995-02-27
Method	SOLUTION NMR
Macromolecule	QUINOMYCIN (protein) DNA (5'-D(APCPAPCPGPTPGPT)-3') (nucleic acid)
Unique Ligands	HQU

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1DSC \| pdb_00001dsc	Download File View File

NMR STUDY OF DNA (5'-D(GPAPAPGPCPTPTPC)-3') SELF-COMPLEMENTARY DUPLEX COMPLEXED WITH ACTINOMYCIN D, MINIMIZED AVERAGE STRUCTURE

Lian, C., Robinson, H., Wang, A.H.-J.

(1996) J Am Chem Soc 118: 8791

Released	1996-12-07
Method	SOLUTION NMR
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) DNA (5'-D(GPAPAPGPCPTPTPC)-3') (nucleic acid)

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1DSD \| pdb_00001dsd	Download File View File

NMR STUDY OF DNA (5'-D(GPAPTPGPCPTPTPC)-3') T:T MISMATCHED DUPLEX COMPLEXED WITH ACTINOMYCIN D, MINIMIZED AVERAGE STRUCTURE

Lian, C., Robinson, H., Wang, A.H.-J.

(1996) J Am Chem Soc 118: 8791

Released	1996-12-07
Method	SOLUTION NMR
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) DNA (5'-D(GPAPTPGPCPTPTPC)-3') (nucleic acid)

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1FJA \| pdb_00001fja	Download File View File

NMR STUDY OF DEOXYRIBONUCLEIC ACID COMPLEXED WITH ACTINOMYCIN D

Chen, H., Liu, X., Patel, D.J.

(1996) J Mol Biology 258: 457

Released	1996-06-10
Method	SOLUTION NMR
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) DNA (5'-D(APAPGPCPGPCPTPT)-3') (nucleic acid)

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1I3W \| pdb_00001i3w	Download File View File

ACTINOMYCIN D BINDING TO CGATCGATCG

Robinson, H., Gao, Y.-G., Yang, X.-L., Sanishvili, R., Joachimiak, A., Wang, A.H.-J.

(2001) Biochemistry 40: 5587

Released	2001-05-21
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) 5'-D(CGPAPTPCPGPAP(BRU)PCPGP)-3' (nucleic acid)

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1L1V \| pdb_00001l1v	Download File View File

UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE

Chou, S.-H., Chin, K.-H., Chen, F.-M.

(2002) Proc Natl Acad Sci U S A 99: 6625

Released	2002-03-06
Method	SOLUTION NMR
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) 5'-D(GPTPCPAPCPCPGPAP*C)-3' (nucleic acid)

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1MNV \| pdb_00001mnv	Download File View File

Actinomycin D binding to ATGCTGCAT

Hou, M.-H., Robinson, H., Gao, Y.-G., Wang, A.H.-J.

(2002) Nucleic Acids Res 30: 4910

Released	2002-11-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) 5'-D(APTPGPCPTPGPCPAP*T)-3' (nucleic acid)

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1OVF \| pdb_00001ovf	Download File View File

NMR Structure of ActD/5'-CCGTTTTGTGG-3' Complex

Chin, K.-H., Chou, S.-H., Chen, F.-M.

(2003) Nucleic Acids Res 31: 2622

Released	2003-05-27
Method	SOLUTION NMR
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) (5'-D(CPCPGPTPTPTPTPGPTPGP*G)-3') (nucleic acid)

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1PFE \| pdb_00001pfe	Download File View File

Echinomycin-(gcgtacgc)2 complex

Cuesta-Seijo, J.A.

(2005) Acta Crystallogr D Biol Crystallogr 61: 442

Released	2004-06-08
Method	X-RAY DIFFRACTION 1.1 Å
Organisms	Streptomyces echinatus
Macromolecule	ECHINOMYCIN (protein) 5'-D(GPCPGPTPAPCPGPC)-3' (nucleic acid)
Unique Ligands	CL, QUI

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1UNJ \| pdb_00001unj	Download File View File

Crystal structure of a 7-Aminoactinomycin D complex with non-complementary DNA

Alexopoulos, E.C., Klement, R., Jares-Erijman, E.A., Uson, I., Jovin, T.M., Sheldrick, G.M.

(2005) Acta Crystallogr D Biol Crystallogr 61: 407

Released	2004-12-16
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Streptomyces antibioticus synthetic construct
Macromolecule	7-AMINO-ACTINOMYCIN D (protein) 5'-D(TPTPAPGPBRUTP)-3' (nucleic acid)

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1UNM \| pdb_00001unm	Download File View File

Crystal structure of 7-Aminoactinomycin D with non-complementary DNA

Alexopoulos, E.C., Klement, R., Jares-Erijman, E.A., Uson, I., Jovin, T.M., Sheldrick, G.M.

(2005) Acta Crystallogr D Biol Crystallogr 61: 407

Released	2004-09-24
Method	X-RAY DIFFRACTION 2 Å
Organisms	Streptomyces antibioticus synthetic construct
Macromolecule	7-AMINOACTINOMYCIN D (protein) 5'-D(TPTPAPGPBRUTP)-3' (nucleic acid)

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1VS2 \| pdb_00001vs2	Download File View File

Interactions of quinoxaline antibiotic and DNA: the molecular structure of a TRIOSTIN A-D(GCGTACGC) complex

Wang, A.H.-J., Ughetto, G., Quigley, G.J., Rich, A.

(1986) J Biomol Struct Dyn 4: 319

Released	2006-06-27
Method	X-RAY DIFFRACTION 2 Å
Organisms	Streptomyces sp.
Macromolecule	TRIOSTIN A (protein) 5'-D(GPCPGPTPAPCPGPC)-3' (nucleic acid)
Unique Ligands	QUI

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1VTG \| pdb_00001vtg	Download File View File

THE MOLECULAR STRUCTURE OF A DNA-TRIOSTIN A COMPLEX

Wang, A.H.-J., Ughetto, G., Quigley, G.J., Hakoshima, T., Van Der Marel, G.A., Van Boom, J.H., Rich, A.

(1984) Science 225: 1115-1121

Released	2011-07-13
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Streptomyces sp. synthetic construct
Macromolecule	triostin A (protein) DNA (5'-D(CPGPTPAPCPG)-3') (nucleic acid)
Unique Ligands	QUI

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1XVK \| pdb_00001xvk	Download File View File

X-ray structure of an Echinomycin-(GCGTACGC)2 complex

Cuesta-Seijo, J.A., Sheldrick, G.M.

(2005) Acta Crystallogr D Biol Crystallogr 61: 442

Released	2005-04-12
Method	X-RAY DIFFRACTION 1.26 Å
Organisms	Streptomyces echinatus
Macromolecule	ECHINOMYCIN (protein) 5'-D(GPCPGPTPAPCPGPC)-3' (nucleic acid)
Unique Ligands	MG, QUI

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1XVN \| pdb_00001xvn	Download File View File

echinomycin (ACGTACGT)2 complex

Cuesta-Seijo, J.A., Sheldrick, G.M.

(2005) Acta Crystallogr D Biol Crystallogr 61: 442

Released	2005-04-12
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Streptomyces echinatus
Macromolecule	ECHINOMYCIN (protein) 5'-D(APCPGPTPAPCPGPT)-3' (nucleic acid)
Unique Ligands	MG, QUI

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1XVR \| pdb_00001xvr	Download File View File

echinomycin (CGTACG)2 complex

Cuesta-Seijo, J.A., Sheldrick, G.M.

(2005) Acta Crystallogr D Biol Crystallogr 61: 442

Released	2005-04-12
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Streptomyces echinatus
Macromolecule	ECHINOMYCIN (protein) 5'-D(CPGPTPAPCPG)-3' (nucleic acid)
Unique Ligands	MG, QUI

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209D \| pdb_0000209d	Download File View File

Structural, physical and biological characteristics of RNA:DNA binding agent N8-actinomycin D

Shinomiya, M., Chu, W., Carlson, R.G., Weaver, R.F., Takusagawa, F.

(1995) Biochemistry 34: 8481

Released	1995-10-15
Method	X-RAY DIFFRACTION 3 Å
Organisms	Streptomyces antibioticus
Macromolecule	N8-ACTINOMYCIN D (protein) DNA (5'-D(GPAPAPGPCPTPTPC)-3') (nucleic acid)

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2ADW \| pdb_00002adw	Download File View File

Crystal structure of Echinomycin-(ACGTACGT)2 solved by SAD

Cuesta-Seijo, J.A., Sheldrick, G.M.

(2006) Acta Crystallogr D Biol Crystallogr 62: 417

Released	2006-03-28
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Streptomyces echinatus
Macromolecule	ECHINOMYCIN (protein) 5'-D(APCPGPTPAPCPGPT)-3' (nucleic acid)
Unique Ligands	MES, NI, QUI, ZN

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2D55 \| pdb_00002d55	Download File View File

Structural, physical and biological characteristics of RNA.DNA binding agent N8-actinomycin D

Shinomiya, M., Chu, W., Carlson, R.G., Weaver, R.F., Takusagawa, F.

(1992) J Mol Biology 225: 445

Released	1995-10-15
Method	X-RAY DIFFRACTION 3 Å
Organisms	Streptomyces antibioticus
Macromolecule	ACTINOMYCIN D (protein) DNA (5'-D(GPAPAPGPCPTPTPC)-3') (nucleic acid)

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2DA8 \| pdb_00002da8	Download File View File

SOLUTION STRUCTURE OF A COMPLEX BETWEEN (N-MECYS3,N-MECYS7)TANDEM AND (D(GATATC))2

Addess, K.J., Sinsheimer, J.S., Feigon, J.

(1993) Biochemistry 32: 2498

Released	1994-01-31
Method	SOLUTION NMR
Organisms	Streptomyces sp.
Macromolecule	CysMeTANDEM quinoxaline antibiotic (protein) DNA (5'-D(GPAPTPAPTPC)-3') (nucleic acid)
Unique Ligands	QUI

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316D \| pdb_0000316d	Download File View File

Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity

Takusagawa, F., Takusagawa, K.T., Carlson, R.G., Weaver, R.F.

(1997) Bioorg Med Chem 5: 1197

Released	1997-11-05
Method	X-RAY DIFFRACTION 3 Å
Organisms	Streptomyces antibioticus
Macromolecule	8-FLUORO-ACTINOMYCIN D (protein) DNA (5'-D(GPAPAPGPCPTPTPC)-3') (nucleic acid)

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3GO3 \| pdb_00003go3	Download File View File

Interactions of an echinomycin-DNA complex with manganese(II) ions

Pfoh, R., Cuesta-Seijo, J.A., Sheldrick, G.M.

(2009) Acta Crystallogr Sect F Struct Biol Cryst Commun 65: 660

Released	2009-03-31
Method	X-RAY DIFFRACTION 1.1 Å
Organisms	Streptomyces echinatus
Macromolecule	ECHINOMYCIN (protein) 5'-D(APCPGPTPAPCPGPT)-3' (nucleic acid)
Unique Ligands	MN, PEG, QUI