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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Keywords HAS EXACT PHRASE "IMMUNE SYSTEM/Cytokine"

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This query matches 12 Structures.

Refinements

Structure Determination Methodology

experimental (12)

Scientific Name of Source Organism

	Homo sapiens (10)
	Mus musculus (4)
	Drosophila melanogaster (2)

Taxonomy

Eukaryota (12)

Experimental Method

X-RAY DIFFRACTION (12)

Polymer Entity Type

Protein (12)

Refinement Resolution (Å)

	1.5 - 2.0 (2)
	2.0 - 2.5 (3)
	2.5 - 3.0 (2)
	3.0 - 3.5 (4)
	4.0 - 4.5 (1)

Release Date

	2000 - 2004 (2)
	2005 - 2009 (4)
	2010 - 2014 (5)
	2015 - 2019 (1)

Symmetry Type

	Asymmetric (11)
	Cyclic (1)

SCOP Classification

	All beta proteins (9)
	All alpha proteins (5)
	Small proteins (3)
	Artifacts (2)

AllSelected

1 to 12 of 12 Structures

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1V7M \| pdb_00001v7m	Download File View File

Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab

Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R.

(2004) Proc Natl Acad Sci U S A 101: 1816-1821

Released	2004-03-02
Method	X-RAY DIFFRACTION 2.51 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Monoclonal TN1 Fab Heavy Chain (protein) Monoclonal TN1 Fab Light Chain (protein) Thrombopoietin (protein)

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1V7N \| pdb_00001v7n	Download File View File

Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab

Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R.

(2004) Proc Natl Acad Sci U S A 101: 1816-1821

Released	2004-03-02
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Monoclonal TN1 Fab Heavy Chain (protein) Monoclonal TN1 Fab Light Chain (protein) Thrombopoietin (protein)

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2ERJ \| pdb_00002erj	Download File View File

Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2

Debler, E.W., Stauber, D.J., Wilson, I.A.

(2006) Proc Natl Acad Sci U S A 103: 2793

Released	2006-02-21
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Cytokine receptor common gamma chain (protein) Interleukin-2 (protein) Interleukin-2 receptor alpha chain (protein) Interleukin-2 receptor beta chain (protein)
Unique Ligands	NAG
Unique branched monosaccharides	BMA, FUC, NAG

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3D85 \| pdb_00003d85	Download File View File

Crystal structure of IL-23 in complex with neutralizing FAB

Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V.

(2008) J Mol Biology 382: 942-955

Released	2008-09-02
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	FAB of antibody 7G10, heavy chain (protein) FAB of antibody 7G10, light chain (protein) Interleukin-12 subunit p40 (protein) Interleukin-23 subunit p19 (protein)
Unique Ligands	IMD, MPD

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3DUH \| pdb_00003duh	Download File View File

Structure of Interleukin-23

Lupardus, P.J., Garcia, K.C.

(2008) J Mol Biology 382: 931-941

Released	2008-08-19
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Interleukin-12 subunit beta (protein) Interleukin-23 subunit alpha (protein)
Unique Ligands	NAG

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3EO1 \| pdb_00003eo1	Download File View File

Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3

Gruetter, C., Gruetter, M.G.

(2008) Proc Natl Acad Sci U S A 105: 20251-20256

Released	2008-12-02
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	GC-1008 Fab Heavy Chain (protein) GC-1008 Fab Light Chain (protein) Transforming growth factor beta-3 (protein)

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3NFP \| pdb_00003nfp	Download File View File

Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain

Yang, H., Wang, J., Du, J., Zhong, C., Guo, Y., Ding, J.

(2010) Cell Res 20: 1361-1371

Released	2010-09-15
Method	X-RAY DIFFRACTION 2.86 Å
Organisms	Homo sapiens
Macromolecule	Heavy chain of Fab fragment of daclizumab (protein) Interleukin-2 receptor subunit alpha (protein) Light chain of Fab fragment of daclizumab (protein)

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3Q1S \| pdb_00003q1s	Download File View File

HIV-1 neutralizing antibody Z13e1 in complex with epitope display protein

Stanfield, R.L., Julien, J.-P., Pejchal, R., Gach, J.S., Zwick, M.B., Wilson, I.A.

(2011) J Mol Biology 414: 460-476

Released	2011-11-02
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Interleukin-22 (protein) Z13e1 Fab heavy chain (protein) Z13e1 Fab light chain (protein)
Unique Ligands	GOL, IPA

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4I77 \| pdb_00004i77	Download File View File

Lebrikizumab Fab bound to IL-13

Eigenbrot, C., Ultsch, M.

(2013) J Mol Biology 425: 1330-1339

Released	2013-02-06
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Interleukin-13 (protein) Lebrikizumab heavy chain (protein) Lebrikizumab light chain (protein)

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4LXR \| pdb_00004lxr	Download File View File

Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity

Stelter, M., Parthier, C., Breithaupt, C., Stubbs, M.T.

(2014) Proc Natl Acad Sci U S A 111: 6281-6286

Released	2014-04-09
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Drosophila melanogaster
Macromolecule	Protein spaetzle C-106 (protein) Protein toll (protein)
Unique Ligands	EPE, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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4LXS \| pdb_00004lxs	Download File View File

Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity (glycosylated form)

Stelter, M., Parthier, C., Breithaupt, C., Stubbs, M.T.

(2014) Proc Natl Acad Sci U S A 111: 6281-6286

Released	2014-04-09
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Drosophila melanogaster
Macromolecule	Protein spaetzle C-106 (protein) Protein toll (protein)
Unique Ligands	EPE, NAG
Unique branched monosaccharides	BMA, MAN, NAG

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4R9Y \| pdb_00004r9y	Download File View File

Crystal structure of KKOFab in complex with platelet factor 4

Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.

(2015) Nat Commun 6: 8277-8277

Released	2015-12-16
Method	X-RAY DIFFRACTION 4.11 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Platelet factor 4 (protein) Platelet factor 4 antibody KKO heavy chain (protein) Platelet factor 4 antibody KKO light chain (protein)

1 to 12 of 12 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1V7M | pdb_00001v7m

Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab

1V7N | pdb_00001v7n

Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab

2ERJ | pdb_00002erj

Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2

3D85 | pdb_00003d85

Crystal structure of IL-23 in complex with neutralizing FAB

3DUH | pdb_00003duh

Structure of Interleukin-23

3EO1 | pdb_00003eo1

Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3

3NFP | pdb_00003nfp

Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain

3Q1S | pdb_00003q1s

HIV-1 neutralizing antibody Z13e1 in complex with epitope display protein

4I77 | pdb_00004i77

Lebrikizumab Fab bound to IL-13

4LXR | pdb_00004lxr

Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity

4LXS | pdb_00004lxs

Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity (glycosylated form)

4R9Y | pdb_00004r9y

Crystal structure of KKOFab in complex with platelet factor 4

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Symmetry Type

SCOP Classification

1V7M | pdb_00001v7m

1V7N | pdb_00001v7n

2ERJ | pdb_00002erj

3D85 | pdb_00003d85

3DUH | pdb_00003duh

3EO1 | pdb_00003eo1

3NFP | pdb_00003nfp

3Q1S | pdb_00003q1s

4I77 | pdb_00004i77

4LXR | pdb_00004lxr

4LXS | pdb_00004lxs

4R9Y | pdb_00004r9y