Download MendeleyThe ligand-free structure of human PPARgamma LBD
Jang, D.M., Han, B.W.To be published.
7CXG
The ligand-free structure of human PPARgamma LBD Q286E mutant
- PDB DOI: https://doi.org/10.2210/pdb7CXG/pdb
- Classification: TRANSCRIPTION
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2020-09-01 Released: 2021-09-01
- Funding Organization(s): National Research Foundation (NRF, Korea)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.88 Å
- R-Value Free: 0.231
- R-Value Work: 0.187
Starting Model: experimental
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This is version 1.1 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Peroxisome proliferator-activated receptor gamma | 283 | Homo sapiens | Mutation(s): 1 Gene Names: PPARG, NR1C3 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P37231 (Homo sapiens) Explore P37231 Go to UniProtKB: P37231 | |||||
PHAROS: P37231 GTEx: ENSG00000132170 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P37231 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GOL (Subject of Investigation/LOI) Query on GOL | C [auth A], D [auth A], E [auth B] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.88 Å
- R-Value Free: 0.231
- R-Value Work: 0.187
- Space Group: C 1 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 91.986 | α = 90 |
| b = 59.886 | β = 103.399 |
| c = 117.761 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| MOLREP | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2021-09-01 Deposition Author(s): Jang, D.M., Han, B.W.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Research Foundation (NRF, Korea) | Korea, Republic Of | 2011-0030001 |
Revision History (Full details and data files)
- Version 1.0: 2021-09-01
Type: Initial release - Version 1.1: 2023-11-29
Changes: Data collection, Derived calculations, Refinement description
