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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 5.3.2.1

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Search Summary

This query matches 144 Structures.

Refinements

Structure Determination Methodology

experimental (144)

Scientific Name of Source Organism

	Homo sapiens (112)
	Leishmania major (4)
	Mus musculus (3)
	Oncomelania hupensis (3)
	Trichomonas vaginalis G3 (3)
	Escherichia coli K-12 (2)
	Plasmodium falciparum (2)
	Plasmodium yoelii yoelii (2)
	Arabidopsis thaliana (1)
	Escherichia coli (1)

More...

Taxonomy

	Eukaryota (140)
	Bacteria (5)

Experimental Method

	X-RAY DIFFRACTION (143)
	NEUTRON DIFFRACTION (1)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (144)

Refinement Resolution (Å)

	1.0 - 1.5 (21)
	1.5 - 2.0 (84)
	2.0 - 2.5 (26)
	2.5 - 3.0 (10)
	3.0 - 3.5 (2)
	3.5 - 4.0 (1)

Release Date

	1995 - 1999 (8)
	2000 - 2004 (8)
	2005 - 2009 (18)
	2010 - 2014 (36)
	2015 - 2019 (42)
	2020 - 2024 (30)
	2025 - 2029 (2)

Enzyme Classification Name

Isomerases (144)

Symmetry Type

	Cyclic (142)
	Tetrahedral (1)
	Asymmetric (1)

SCOP Classification

	Alpha and beta proteins (a+b) (117)
	Artifacts (19)

AllSelected

1 to 25 of 144 Structures

Page 1 of 6

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1CA7 \| pdb_00001ca7	Download File View File

MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXPHENYLPYRUVATE

Lubetsky, J.B., Lolis, E.

(1999) Biochemistry 38: 7346-7354

Released	1999-06-30
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) (protein)
Unique Ligands	EN1

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1CGQ \| pdb_00001cgq	Download File View File

MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH ALANINE INSERTED BETWEEN PRO-1 AND MET-2

Lubetsky, J.B., Lolis, E.

(1999) Biochemistry 38: 7346-7354

Released	1999-06-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) (protein)

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1FIM \| pdb_00001fim	Download File View File

MACROPHAGE MIGRATION INHIBITORY FACTOR

Suzuki, M., Sugimoto, H., Nakagawa, A., Tanaka, I.

(1996) Nat Struct Biol 3: 259-266

Released	1996-07-11
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Rattus norvegicus
Macromolecule	MACROPHAGE MIGRATION INHIBITORY FACTOR (protein)

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1GCZ \| pdb_00001gcz	Download File View File

MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) COMPLEXED WITH INHIBITOR.

Katayama, N., Kurihara, H.

(2001) J Med Chem 44: 540-547

Released	2001-02-21
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	MACROPHAGE MIGRATION INHIBITORY FACTOR (protein)
Unique Ligands	CIT, SO4, YZ9

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1GD0 \| pdb_00001gd0	Download File View File

HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)

Kurihara, H., Katayama, N.

(2001) J Med Chem 44: 540-547

Released	2001-02-21
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	MACROPHAGE MIGRATION INHIBITORY FACTOR (protein)
Unique Ligands	CIT, SO4

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1GIF \| pdb_00001gif	Download File View File

HUMAN GLYCOSYLATION-INHIBITING FACTOR

Kato, Y., Kuroki, R.

(1996) Proc Natl Acad Sci U S A 93: 3007-3010

Released	1997-03-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	GLYCOSYLATION-INHIBITING FACTOR (protein)

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1GYJ \| pdb_00001gyj	Download File View File

The Crystal Structure of YdcE, a 4-Oxalocrotonate Tautomerase Homologue from Escherichia coli, Confirms the Structural Basis for Oligomer Diversity

Almrud, J., Kern, A., Wang, S., Czerwinski, R., Johnson, W., Murzin, A., Hackert, M., Whitman, C.

(2002) Biochemistry 41: 12010

Released	2002-10-10
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Escherichia coli K-12
Macromolecule	HYPOTHETICAL PROTEIN YDCE (protein)

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1GYX \| pdb_00001gyx	Download File View File

The Crystal Structure of YdcE, a 4-Oxalocrotonate Tautomerase Homologue from Escherichia coli, Confirms the Structural Basis for Oligomer Diversity

Almrud, J., Kern, A., Wang, S., Czerwinski, R., Johnson, W., Murzin, A., Hackert, M., Whitman, C.

(2002) Biochemistry 41: 12010-12024

Released	2002-10-10
Method	X-RAY DIFFRACTION 1.35 Å
Organisms	Escherichia coli K-12
Macromolecule	HYPOTHETICAL PROTEIN YDCE (protein)
Unique Ligands	BEZ, EPE

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1GYY \| pdb_00001gyy	Download File View File

The Crystal Structure of YdcE, a 4-Oxalocrotonate Tautomerase Homologue from Escherichia coli, Confirms the Structural Basis for Oligomer Diversity

Almrud, J., Kern, A., Wang, S., Czerwinski, R., Johnson, W., Murzin, A., Hackert, M., Whitman, C.

(2002) Biochemistry 41: 12010

Released	2002-10-10
Method	X-RAY DIFFRACTION 1.35 Å
Organisms	Escherichia coli
Macromolecule	HYPOTHETICAL PROTEIN YDCE (protein)
Unique Ligands	FHC

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1HFO \| pdb_00001hfo	Download File View File

The Structure of the Macrophage Migration Inhibitory Factor from Trichinella Spiralis.

Roe, S.M., Meyer, D.J.

(2001) Biochem J 357: 373

Released	2001-08-30
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Trichinella spiralis
Macromolecule	MIGRATION INHIBITORY FACTOR (protein)

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1LJT \| pdb_00001ljt	Download File View File

Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1)

Lubetsky, J.B., Dios, A., Han, J., Aljabari, B., Ruzsicska, B., Mitchell, R., Lolis, E., Al-Abed, Y.

(2002) J Biological Chem 277: 24976-24982

Released	2002-11-27
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Macrophage migration inhibitory factor (protein)
Unique Ligands	HDI

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1MFF \| pdb_00001mff	Download File View File

MACROPHAGE MIGRATION INHIBITORY FACTOR Y95F MUTANT

Taylor, A.B., Stamps, S.L., Wang, S.C., Hackert, M.L., Whitman, C.P.

(2000) Biochemistry 39: 9671-9678

Released	1999-07-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mus musculus
Macromolecule	MACROPHAGE MIGRATION INHIBITORY FACTOR (protein)

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1MFI \| pdb_00001mfi	Download File View File

CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR COMPLEXED WITH (E)-2-FLUORO-P-HYDROXYCINNAMATE

Taylor, A.B., Johnson Jr., W.H., Czerwinski, R.M., Whitman, C.P., Hackert, M.L.

(1999) Biochemistry 38: 7444-7452

Released	1999-06-22
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Mus musculus
Macromolecule	PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) (protein)
Unique Ligands	FHC

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1MIF \| pdb_00001mif	Download File View File

MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)

Sun, H.-W., Lolis, E.

(1996) Proc Natl Acad Sci U S A 93: 5191-5196

Released	1996-12-07
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	MACROPHAGE MIGRATION INHIBITORY FACTOR (protein)

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1P1G \| pdb_00001p1g	Download File View File

MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH PRO-1 MUTATED TO GLY-1

Lubetsky, J.B., Lolis, E.

(1999) Biochemistry 38: 7346-7354

Released	1999-06-07
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) (protein)

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1UIZ \| pdb_00001uiz	Download File View File

Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.

Suzuki, M., Takamura, Y., Maeno, M., Tochinai, S., Iyaguchi, D., Tanaka, I., Nishihira, J., Ishibashi, T.

(2004) J Biological Chem 279: 21406-21414

Released	2004-05-25
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Xenopus laevis
Macromolecule	Macrophage Migration Inhibitory Factor (protein)

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2GDG \| pdb_00002gdg	Download File View File

Crystal structure of covalently modified macrophage inhibitory factor

Golubkov, P.A., Hackert, M.L.

(2006) Bioorg Chem 34: 183-199

Released	2006-07-04
Method	X-RAY DIFFRACTION 1.45 Å
Organisms	Mus musculus
Macromolecule	Macrophage migration inhibitory factor (protein)

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2OOH \| pdb_00002ooh	Download File View File

Crystal Structure of MIF bound to a Novel Inhibitor, OXIM-11

Crichlow, G.V., Al-Abed, Y., Lolis, E.

(2007) J Biological Chem 282: 23089-23095

Released	2007-06-05
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Macrophage migration inhibitory factor (protein)
Unique Ligands	GOL, OX3, SO4

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2OOW \| pdb_00002oow	Download File View File

MIF Bound to a Fluorinated OXIM Derivative

Crichlow, G.V., Al-Abed, Y., Lolis, E.

(2007) J Biological Chem 282: 23089-23095

Released	2007-06-05
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Macrophage migration inhibitory factor (protein)
Unique Ligands	GOL, IPA, OX4, SO4

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2OOZ \| pdb_00002ooz	Download File View File

Macrophage Migration Inhibitory Factor (MIF) Complexed with OXIM6 (an OXIM Derivative Not Containing a Ring in its R-group)

Crichlow, G.V., Al-Abed, Y., Lolis, E.

(2007) J Biological Chem 282: 23089-23095

Released	2007-06-05
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Macrophage migration inhibitory factor (protein)
Unique Ligands	GOL, IPA, OX5, SO4

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2WKF \| pdb_00002wkf	Download File View File

Crystal Structure of Macrophage Migration Inhibitory Factor from Plasmodium falciparum

Dobson, S.E., Augustijn, K.D., Brannigan, J.A., Dodson, E.J., Waters, A.P., Wilkinson, A.J.

(2009) Protein Sci 18: 2578-2591

Released	2009-10-27
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	MACROPHAGE MIGRATION INHIBITORY FACTOR (protein)
Unique Ligands	GOL

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2XCZ \| pdb_00002xcz	Download File View File

Crystal Structure of macrophage migration inhibitory factor homologue from Prochlorococcus marinus

Wasiel, A.A., Rozeboom, H.J., Hauke, D., Baas, B.J., Zandvoort, E., Quax, W.J., Thunnissen, A.M.W.H., Poelarends, G.J.

(2010) Biochemistry 49: 7572

Released	2010-09-01
Method	X-RAY DIFFRACTION 1.64 Å
Organisms	Prochlorococcus marinus str. MIT 9313
Macromolecule	POSSIBLE ATLS1-LIKE LIGHT-INDUCIBLE PROTEIN (protein)
Unique Ligands	PEG

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3B64 \| pdb_00003b64	Download File View File

Macrophage Migration Inhibitory Factor (MIF) From /Leishmania Major

Zierow, S., Cho, Y., Lolis, E.

(2008) J Immunol 180: 8250-8261

Released	2008-06-10
Method	X-RAY DIFFRACTION 1.03 Å
Organisms	Leishmania major
Macromolecule	Macrophage migration inhibitory factor-like protein (protein)
Unique Ligands	IPA

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3B9S \| pdb_00003b9s	Download File View File

Macrophage Migration Inhibitory Factor (MIF) complexed with Inhibitor, 4-IPP.

Zierow, S., Crichlow, G., Lolis, E.

(2008) Cancer Res 68: 7253-7257

Released	2008-09-23
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Macrophage Migration Inhibitory Factor (protein)
Unique Ligands	GOL, RW1, SO4

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3CE4 \| pdb_00003ce4	Download File View File

Structure of Macrophage Migration Inhibitory Factor Covalently Inhibited by PMSF Treatment

Crichlow, G.V., Lolis, E.

(2009) Biochemistry 48: 132-139

Released	2008-12-30
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens
Macromolecule	Macrophage migration inhibitory factor (protein)
Unique Ligands	GOL, IPA, PMS, SO4

1 to 25 of 144 Structures

Page 1 of 6

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1CA7 | pdb_00001ca7

1CGQ | pdb_00001cgq

1FIM | pdb_00001fim

1GCZ | pdb_00001gcz

1GD0 | pdb_00001gd0

1GIF | pdb_00001gif

1GYJ | pdb_00001gyj

1GYX | pdb_00001gyx

1GYY | pdb_00001gyy

1HFO | pdb_00001hfo

1LJT | pdb_00001ljt

1MFF | pdb_00001mff

1MFI | pdb_00001mfi

1MIF | pdb_00001mif

1P1G | pdb_00001p1g

1UIZ | pdb_00001uiz

2GDG | pdb_00002gdg

2OOH | pdb_00002ooh

2OOW | pdb_00002oow

2OOZ | pdb_00002ooz

2WKF | pdb_00002wkf

2XCZ | pdb_00002xcz

3B64 | pdb_00003b64

3B9S | pdb_00003b9s

3CE4 | pdb_00003ce4