Annotations: 1A9C

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
O	d1a9co_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
N	d1a9cn_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
M	d1a9cm_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
L	d1a9cl_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
K	d1a9ck_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
J	d1a9cj_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
I	d1a9ci_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H	d1a9ch_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d1a9cg_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1a9cf_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d1a9ce_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1a9cd_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1a9cc_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1a9cb_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1a9ca_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
O	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
O	GTP_cyclohydroI	e1a9cO1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
N	GTP_cyclohydroI	e1a9cN1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
M	GTP_cyclohydroI	e1a9cM1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
L	GTP_cyclohydroI	e1a9cL1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
K	GTP_cyclohydroI	e1a9cK1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
J	GTP_cyclohydroI	e1a9cJ1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
I	GTP_cyclohydroI	e1a9cI1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
H	GTP_cyclohydroI	e1a9cH1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
G	GTP_cyclohydroI	e1a9cG1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
F	GTP_cyclohydroI	e1a9cF1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
E	GTP_cyclohydroI	e1a9cE1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
D	GTP_cyclohydroI	e1a9cD1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
C	GTP_cyclohydroI	e1a9cC1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
B	GTP_cyclohydroI	e1a9cB1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
A	GTP_cyclohydroI	e1a9cA1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
O	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
O	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
N	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
N	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
M	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
M	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
L	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
L	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
K	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
K	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
J	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
J	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
I	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
I	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
H	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
H	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
G	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
G	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
F	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
F	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
E	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
E	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
D	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
D	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
C	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
C	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
B	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
B	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
A	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
A	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O	PF01227	GTP cyclohydrolase I (GTP_cyclohydroI)	GTP cyclohydrolase I	This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins including Swiss:Q46920.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O	GTP CYCLOHYDROLASE I	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GTP cyclohydrolase activity cyclohydrolase activity hydrolase activity GTP cyclohydrolase I activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GTP cyclohydrolase activity cyclohydrolase activity hydrolase activity GTP cyclohydrolase I activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding identical protein binding protein binding	tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA queuosine(34) biosynthetic process tRNA wobble guanine modification tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA queuosine(34) biosynthetic process tRNA wobble guanine modification tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing macromolecule modification metabolic process cellular process tRNA wobble base modification macromolecule metabolic process RNA processing small molecule metabolic process one-carbon metabolic process polyol metabolic process small molecule biosynthetic process alcohol metabolic process diol biosynthetic process diol metabolic process tetrahydrobiopterin biosynthetic process tetrahydrobiopterin metabolic process pteridine-containing compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process pteridine-containing compound metabolic process folic acid-containing compound biosynthetic process modified amino acid biosynthetic process modified amino acid metabolic process folic acid-containing compound metabolic process tetrahydrofolate biosynthetic process tetrahydrofolate metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O	IPR020602	GTP cyclohydrolase I domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O	IPR043133	GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O	IPR043134	GTP cyclohydrolase I, N-terminal domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O	IPR018234	GTP cyclohydrolase I, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O	IPR001474	GTP cyclohydrolase I	Family