1BNL | pdb_00001bnl

ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d1bnld_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Endostatin	Endostatin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1bnlc_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Endostatin	Endostatin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1bnlb_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Endostatin	Endostatin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1bnla_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Endostatin	Endostatin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	C-type lectin-like	8037139	3001261	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C-type lectin-like	8037139	3001261	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	C-type lectin-like	8037139	3001261	SCOP2B (2022-06-29)
A	SCOP2 Family	Endostatin	8024760	4002514	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C-type lectin-like	8037139	3001261	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Endostatin_C	e1bnlD1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Endostatin_C	ECOD (1.6)
C	Endostatin_C	e1bnlC1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Endostatin_C	ECOD (1.6)
B	Endostatin_C	e1bnlB1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Endostatin_C	ECOD (1.6)
A	Endostatin_C	e1bnlA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Endostatin_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
C	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
B	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
A	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF06482	Collagenase NC10 and Endostatin (Endostatin)	Collagenase NC10 and Endostatin	NC10 stands for Non-helical region 10 and is taken from Swiss:P39059. A mutation in this region in Swiss:P39060 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a ...	NC10 stands for Non-helical region 10 and is taken from Swiss:P39059. A mutation in this region in Swiss:P39060 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor ([1]). Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance according to ([2]).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	COLLAGEN XVIII	structural molecule activity extracellular matrix structural constituent extracellular matrix structural constituent conferring tensile strength cation binding ion binding binding metal ion binding small molecule binding	response to stimulus response to chemical response to xenobiotic stimulus developmental process epithelium development endothelial cell differentiation cellular developmental process endothelium development cell development tissue development epithelial cell differentiation cell morphogenesis endothelial cell development anatomical structure morphogenesis response to stimulus response to chemical response to xenobiotic stimulus developmental process epithelium development endothelial cell differentiation cellular developmental process endothelium development cell development tissue development epithelial cell differentiation cell morphogenesis endothelial cell development anatomical structure morphogenesis epithelial cell development endothelial cell morphogenesis epithelial cell morphogenesis cell differentiation anatomical structure development cellular process animal organ development animal organ morphogenesis multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development system development skeletal system development negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process cell adhesion sensory perception of light stimulus system process sensory perception nervous system process visual perception response to acid chemical response to stress response to hydrostatic pressure response to oxygen-containing compound response to abiotic stimulus response to water	protein-containing complex collagen trimer basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space protein-containing complex collagen trimer basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR008160	Collagen triple helix repeat	Repeat
A, B, C, D	IPR036790	Frizzled cysteine-rich domain superfamily	Homologous Superfamily
A, B, C, D	IPR016187	C-type lectin fold	Homologous Superfamily
A, B, C, D	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C, D	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, B, C, D	IPR010363	Domain of unknown function DUF959, collagen XVIII, N-terminal	Domain
A, B, C, D	IPR010515	Collagenase NC10/endostatin	Domain
A, B, C, D	IPR035523	Collagen alpha-1(XVIII) chain, frizzled domain	Domain
A, B, C, D	IPR048287	Thrombospondin-like, N-terminal domain	Domain
A, B, C, D	IPR045463	Collagen type XV/XVIII, trimerization domain	Domain
A, B, C, D	IPR050149	Collagen superfamily	Family
A, B, C, D	IPR020067	Frizzled domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P39060	Knobloch syndrome angiosarcoma intellectual disability calcinosis heart valve disease pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor transitional cell carcinoma cataract glaucoma malignant ependymoma medulloblastoma Microcalcification pancreatic intraductal papillary-mucinous carcinoma Knobloch syndrome angiosarcoma intellectual disability calcinosis heart valve disease pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor transitional cell carcinoma cataract glaucoma malignant ependymoma medulloblastoma Microcalcification pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma atypical teratoid rhabdoid tumor glioblastoma interstitial cystitis malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer thoracic aortic aneurysm ulcerative colitis gastric carcinoma malignant mesothelioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.