1C6V | pdb_00001c6v

SIV INTEGRASE (CATALYTIC DOMAIN + DNA BIDING DOMAIN COMPRISING RESIDUES 50-293) MUTANT WITH PHE 185 REPLACED BY HIS (F185H)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth X]	d1c6vx_	All beta proteins	SH3-like barrel	DNA-binding domain of retroviral integrase	DNA-binding domain of retroviral integrase	DNA-binding domain of retroviral integrase	(Simian immunodeficiency virus ) [TaxId: 11723 ],	SCOPe (2.08)
D	d1c6vd_	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Ribonuclease H-like	Retroviral integrase, catalytic domain	Retroviral integrase, catalytic domain	(Simian immunodeficiency virus ) [TaxId: 11723 ],	SCOPe (2.08)
C	d1c6vc_	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Ribonuclease H-like	Retroviral integrase, catalytic domain	Retroviral integrase, catalytic domain	(Simian immunodeficiency virus ) [TaxId: 11723 ],	SCOPe (2.08)
B	d1c6vb_	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Ribonuclease H-like	Retroviral integrase, catalytic domain	Retroviral integrase, catalytic domain	(Simian immunodeficiency virus ) [TaxId: 11723 ],	SCOPe (2.08)
A	d1c6va_	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Ribonuclease H-like	Retroviral integrase, catalytic domain	Retroviral integrase, catalytic domain	(Simian immunodeficiency virus ) [TaxId: 11723 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth X]	SCOP2 Family	DNA-binding domain of retroviral integrase	8029306	4001775	SCOP2 (2022-06-29)
E [auth X]	SCOP2 Superfamily	DNA-binding domain of retroviral integrase	8041685	3000355	SCOP2 (2022-06-29)
A	SCOP2 Family	Retroviral integrase, catalytic domain	8032156	4000539	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ribonuclease H-like	8044534	3000143	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth X]	IN_DBD_C	e1c6vX1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: IN_DBD_C	ECOD (1.6)
D	rve	e1c6vD1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: rve	ECOD (1.6)
C	rve	e1c6vC1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: rve	ECOD (1.6)
B	rve	e1c6vB1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: rve	ECOD (1.6)
A	rve	e1c6vA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: rve	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth X]	2.30.30.10	Mainly Beta	Roll	SH3 type barrels.	Integrase, C-terminal domain superfamily, retroviral	CATH (4.3.0)
D	3.30.420.10	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C	3.30.420.10	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
B	3.30.420.10	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.30.420.10	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth X]	PF00552	Integrase DNA binding domain (IN_DBD_C)	Integrase DNA binding domain	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain. The central domain is the catalytic domain Pfam:PF00665. This dom ...	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain. The central domain is the catalytic domain Pfam:PF00665. This domain is the carboxyl terminal domain that is a non-specific DNA binding domain [1].	Domain
A, B, C, D	PF00665	Integrase core domain (rve)	Integrase core domain	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The ca ...	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E [auth X]	PROTEIN (SIU89134)	catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity hydrolase activity, acting on ester bonds nuclease activity exoribonuclease H activity exonuclease activity catalytic activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity hydrolase activity, acting on ester bonds nuclease activity exoribonuclease H activity exonuclease activity catalytic activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups DNA binding binding nucleic acid binding RNA-directed DNA polymerase activity RNA binding RNA stem-loop binding aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein aspartic-type endopeptidase activity endopeptidase activity endonuclease activity RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism RNA-DNA hybrid ribonuclease activity RNA endonuclease activity structural molecule activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host viral life cycle viral genome integration into host DNA viral penetration into host nucleus symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host viral life cycle viral genome integration into host DNA viral penetration into host nucleus intracellular transport of virus transport of virus nucleobase-containing compound metabolic process metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process DNA integration nucleic acid metabolic process establishment of integrated proviral latency viral latency establishment of viral latency viral gene expression viral translational frameshifting viral translation DNA recombination proteolysis protein metabolic process	cellular anatomical structure membrane host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region other organism part viral nucleocapsid viral capsid virion component host cell plasma membrane host cell membrane host cell cellular anatomical structure membrane host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region other organism part viral nucleocapsid viral capsid virion component host cell plasma membrane host cell membrane host cell host intracellular membrane-bounded organelle host cell nucleus host intracellular organelle
A, B, C, D	PROTEIN (SIV INTEGRASE)	catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity hydrolase activity, acting on ester bonds nuclease activity exoribonuclease H activity exonuclease activity catalytic activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity hydrolase activity, acting on ester bonds nuclease activity exoribonuclease H activity exonuclease activity catalytic activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups DNA binding binding nucleic acid binding RNA-directed DNA polymerase activity RNA binding RNA stem-loop binding aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein aspartic-type endopeptidase activity endopeptidase activity endonuclease activity RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism RNA-DNA hybrid ribonuclease activity RNA endonuclease activity structural molecule activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host viral life cycle viral genome integration into host DNA viral penetration into host nucleus symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host viral life cycle viral genome integration into host DNA viral penetration into host nucleus intracellular transport of virus transport of virus nucleobase-containing compound metabolic process metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process DNA integration nucleic acid metabolic process establishment of integrated proviral latency viral latency establishment of viral latency viral gene expression viral translational frameshifting viral translation DNA recombination proteolysis protein metabolic process	cellular anatomical structure membrane host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region other organism part viral nucleocapsid viral capsid virion component host cell plasma membrane host cell membrane host cell cellular anatomical structure membrane host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region other organism part viral nucleocapsid viral capsid virion component host cell plasma membrane host cell membrane host cell host intracellular membrane-bounded organelle host cell nucleus host intracellular organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth X]	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
E [auth X]	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
E [auth X]	IPR001995	Peptidase A2A, retrovirus, catalytic	Domain
E [auth X]	IPR001878	Zinc finger, CCHC-type	Domain
E [auth X]	IPR008919	Retrovirus capsid, N-terminal	Homologous Superfamily
E [auth X]	IPR012344	Matrix protein, lentiviral and alpha-retroviral, N-terminal	Homologous Superfamily
E [auth X]	IPR036862	Integrase, C-terminal domain superfamily, retroviral	Homologous Superfamily
E [auth X]	IPR018061	Retropepsins	Domain
E [auth X]	IPR010661	Reverse transcriptase thumb	Domain
E [auth X]	IPR002156	Ribonuclease H domain	Domain
E [auth X]	IPR036875	Zinc finger, CCHC-type superfamily	Homologous Superfamily
E [auth X]	IPR003308	Integrase, N-terminal zinc-binding domain	Domain
E [auth X]	IPR001584	Integrase, catalytic core	Domain
E [auth X]	IPR045345	Retroviral nucleocapsid Gag protein p24, C-terminal domain	Domain
E [auth X]	IPR010999	Retroviral matrix protein	Homologous Superfamily
E [auth X]	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
E [auth X]	IPR001969	Aspartic peptidase, active site	Active Site
E [auth X]	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
E [auth X]	IPR017856	Integrase-like, N-terminal	Homologous Superfamily
E [auth X]	IPR000071	Immunodeficiency lentiviral matrix, N-terminal	Domain
E [auth X]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
E [auth X]	IPR001037	Integrase, C-terminal, retroviral	Domain
E [auth X]	IPR034170	Retropepsin-like catalytic domain	Domain
E [auth X]	IPR000477	Reverse transcriptase domain	Domain
E [auth X]	IPR010659	Reverse transcriptase connection	Domain
E [auth X]	IPR008916	Retrovirus capsid, C-terminal	Homologous Superfamily
A, B, C, D	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
A, B, C, D	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
A, B, C, D	IPR001995	Peptidase A2A, retrovirus, catalytic	Domain
A, B, C, D	IPR001878	Zinc finger, CCHC-type	Domain
A, B, C, D	IPR008919	Retrovirus capsid, N-terminal	Homologous Superfamily
A, B, C, D	IPR012344	Matrix protein, lentiviral and alpha-retroviral, N-terminal	Homologous Superfamily
A, B, C, D	IPR036862	Integrase, C-terminal domain superfamily, retroviral	Homologous Superfamily
A, B, C, D	IPR018061	Retropepsins	Domain
A, B, C, D	IPR010661	Reverse transcriptase thumb	Domain
A, B, C, D	IPR002156	Ribonuclease H domain	Domain
A, B, C, D	IPR036875	Zinc finger, CCHC-type superfamily	Homologous Superfamily
A, B, C, D	IPR003308	Integrase, N-terminal zinc-binding domain	Domain
A, B, C, D	IPR001584	Integrase, catalytic core	Domain
A, B, C, D	IPR045345	Retroviral nucleocapsid Gag protein p24, C-terminal domain	Domain
A, B, C, D	IPR010999	Retroviral matrix protein	Homologous Superfamily
A, B, C, D	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A, B, C, D	IPR001969	Aspartic peptidase, active site	Active Site
A, B, C, D	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
A, B, C, D	IPR017856	Integrase-like, N-terminal	Homologous Superfamily
A, B, C, D	IPR000071	Immunodeficiency lentiviral matrix, N-terminal	Domain
A, B, C, D	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
A, B, C, D	IPR001037	Integrase, C-terminal, retroviral	Domain
A, B, C, D	IPR034170	Retropepsin-like catalytic domain	Domain
A, B, C, D	IPR000477	Reverse transcriptase domain	Domain
A, B, C, D	IPR010659	Reverse transcriptase connection	Domain
A, B, C, D	IPR008916	Retrovirus capsid, C-terminal	Homologous Superfamily