1E79

Bovine F1-ATPase inhibited by DCCD (dicyclohexylcarbodiimide)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1e79a1	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase alpha subunit, domain 3	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d1e79a2	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	N-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase alpha subunit, domain 1	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d1e79a3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	Central domain of alpha subunit of F1 ATP synthase	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1e79b1	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase alpha subunit, domain 3	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1e79b2	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	N-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase alpha subunit, domain 1	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1e79b3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	Central domain of alpha subunit of F1 ATP synthase	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1e79c1	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase alpha subunit, domain 3	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1e79c2	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	N-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase alpha subunit, domain 1	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1e79c3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	Central domain of alpha subunit of F1 ATP synthase	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d1e79d1	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase beta subunit, domain 3	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d1e79d2	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	N-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase beta subunit, domain 1	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d1e79d3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	Central domain of beta subunit of F1 ATP synthase	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F	d1e79f1	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase beta subunit, domain 3	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F	d1e79f2	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	N-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase beta subunit, domain 1	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F	d1e79f3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	Central domain of beta subunit of F1 ATP synthase	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E	d1e79e1	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase beta subunit, domain 3	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E	d1e79e2	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	N-terminal domain of alpha and beta subunits of F1 ATP synthase	F1 ATP synthase beta subunit, domain 1	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E	d1e79e3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	Central domain of beta subunit of F1 ATP synthase	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
G	d1e79g_	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	ATP synthase (F1-ATPase), gamma subunit	ATP synthase (F1-ATPase), gamma subunit	F1 ATP synthase gamma subunit	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
H	d1e79h1	All alpha proteins	Long alpha-hairpin	Epsilon subunit of F1F0-ATP synthase C-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
H	d1e79h2	All beta proteins	Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase N-terminal domain	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
I	d1e79i_	All alpha proteins	Non-globular all-alpha subunits of globular proteins	Epsilon subunit of mitochondrial F1F0-ATP synthase	Epsilon subunit of mitochondrial F1F0-ATP synthase	Epsilon subunit of mitochondrial F1F0-ATP synthase	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RecA-like P-loop NTPases	8018243	3002019	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ATP synthase alpha/beta C-terminal domain-like	8056868	3000684	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018248	3001034	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RecA-like P-loop NTPases	8018243	3002019	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018248	3001034	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ATP synthase alpha/beta C-terminal domain-like	8056868	3000684	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RecA-like P-loop NTPases	8018243	3002019	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ATP synthase alpha/beta C-terminal domain-like	8056868	3000684	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018248	3001034	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ATP synthase alpha/beta C-terminal domain-like	8056904	3000684	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018258	3001034	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RecA-like P-loop NTPases	8018253	3002019	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	RecA-like P-loop NTPases	8018253	3002019	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ATP synthase alpha/beta C-terminal domain-like	8056904	3000684	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018258	3001034	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018258	3001034	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RecA-like P-loop NTPases	8018253	3002019	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ATP synthase alpha/beta C-terminal domain-like	8056904	3000684	SCOP2B (2022-06-29)
G	SCOP2 Family	ATP synthase gamma subunit-like	8032034	4000503	SCOP2 (2022-06-29)
G	SCOP2 Superfamily	ATP synthase gamma subunit-like	8044412	3000451	SCOP2 (2022-06-29)
H	SCOP2B Superfamily	Epsilon subunit of F1F0-ATP synthase N-terminal domain	8037352	3000182	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Epsilon subunit of F1F0-ATP synthase C-terminal domain	8037350	3000785	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	epsilon subunit of mitochondrial F1F0-ATP synthase	8037353	3001799	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ATP-synt_ab_N	e1e79A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
A	ATP-synt_ab_C	e1e79A2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
A	ATP-synt_ab	e1e79A3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
B	ATP-synt_ab_N	e1e79B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
B	ATP-synt_ab_C	e1e79B2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
B	ATP-synt_ab	e1e79B3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
C	ATP-synt_ab_N	e1e79C1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
C	ATP-synt_ab_C	e1e79C2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
C	ATP-synt_ab	e1e79C3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
D	ATP-synt_ab_N	e1e79D1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
D	ATP-synt_ab_C	e1e79D3	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
D	ATP-synt_ab	e1e79D2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
F	ATP-synt_ab_N	e1e79F1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
F	ATP-synt_ab_C	e1e79F3	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
F	ATP-synt_ab	e1e79F2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
E	ATP-synt_ab_N	e1e79E1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
E	ATP-synt_ab_C	e1e79E3	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
E	ATP-synt_ab	e1e79E2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
G	ATP-synt	e1e79G2	A: a/b three-layered sandwiches	X: ATP synthase (F1-ATPase), gamma subunit (From Topology)	H: ATP synthase (F1-ATPase), gamma subunit (From Topology)	T: ATP synthase (F1-ATPase), gamma subunit	F: ATP-synt	ECOD (1.6)
H	ATP-synt_DE_N	e1e79H1	A: beta sandwiches	X: Epsilon subunit of F1F0-ATP synthase-N	H: Epsilon subunit of F1F0-ATP synthase-N (From Topology)	T: Epsilon subunit of F1F0-ATP synthase-N	F: ATP-synt_DE_N	ECOD (1.6)
H	KOG1758	e1e79H2	A: alpha bundles	X: Long alpha-hairpin	H: Epsilon subunit of F1F0-ATP synthase C-terminal domain (From Topology)	T: Epsilon subunit of F1F0-ATP synthase C-terminal domain	F: KOG1758	ECOD (1.6)
I	ATP-synt_Eps	e1e79I1	A: extended segments	X: Epsilon subunit of mitochondrial F1F0-ATP synthase (From Topology)	H: Epsilon subunit of mitochondrial F1F0-ATP synthase (From Topology)	T: Epsilon subunit of mitochondrial F1F0-ATP synthase	F: ATP-synt_Eps	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.30.20	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	1.20.150.20	Mainly Alpha	Up-down Bundle	Lysin	ATP synthase alpha/beta chain, C-terminal domain	CATH (4.3.0)
B	2.40.30.20	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	1.20.150.20	Mainly Alpha	Up-down Bundle	Lysin	ATP synthase alpha/beta chain, C-terminal domain	CATH (4.3.0)
C	2.40.30.20	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	1.20.150.20	Mainly Alpha	Up-down Bundle	Lysin	ATP synthase alpha/beta chain, C-terminal domain	CATH (4.3.0)
D	2.40.10.170	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	1.10.1140.10	Mainly Alpha	Orthogonal Bundle	Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain	Chain D, domain3	CATH (4.3.0)
F	2.40.10.170	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
F	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
F	1.10.1140.10	Mainly Alpha	Orthogonal Bundle	Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain	Chain D, domain3	CATH (4.3.0)
E	2.40.10.170	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E	1.10.1140.10	Mainly Alpha	Orthogonal Bundle	Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain	Chain D, domain3	CATH (4.3.0)
G	1.10.287.80	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ATP synthase, gamma subunit, helix hairpin domain	CATH (4.3.0)
G	3.40.1380.10	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
H	2.60.15.10	Mainly Beta	Sandwich	ATP Synthase	domain 1	CATH (4.3.0)
H	1.20.5.440	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	ATP synthase delta/epsilon subunit, C-terminal domain	CATH (4.3.0)
I	1.10.1620.20	Mainly Alpha	Orthogonal Bundle	Atp Synthase Epsilon Chain	Chain: I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
A, B, C	PF00306	ATP synthase alpha/beta chain, C terminal domain (ATP-synt_ab_C)	ATP synthase alpha/beta chain, C terminal domain	-	Domain
A, B, C	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
D, E, F	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
D, E, F	PF22919	C-terminal domain of V and A type ATP synthase (ATP-synt_VA_C)	C-terminal domain of V and A type ATP synthase	This entry represents a small alpha helical domain found at the C-terminus of a variety of ATP synthases.	Domain
D, E, F	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
G	PF00231	ATP synthase (ATP-synt)	ATP synthase	-	Domain
H	PF02823	ATP synthase, Delta/Epsilon chain, beta-sandwich domain (ATP-synt_DE_N)	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria. In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensit ...	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria. In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).	Domain
H	PF21335	Metazoan delta subunit of F1F0-ATP synthase, C-terminal domain (ATPD_C_metazoa)	Metazoan delta subunit of F1F0-ATP synthase, C-terminal domain	F-type ATPases consist of two structural domains, F1 containing the extramembraneous catalytic core, and F0 which contains the membrane proton channel. This entry includes ATP synthase subunit delta from animals (called epsilon in bacteria or chlorop ...	F-type ATPases consist of two structural domains, F1 containing the extramembraneous catalytic core, and F0 which contains the membrane proton channel. This entry includes ATP synthase subunit delta from animals (called epsilon in bacteria or chloroplast ATPase), which interacts with subunit C from F0 which is important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 C subunit). This entry represents the C-terminal alpha-helical domain which is likely to act as an inhibitor of ATPase activity [1-5].	Domain
I	PF04627	Mitochondrial ATP synthase epsilon chain (ATP-synt_Eps)	Mitochondrial ATP synthase epsilon chain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	ATP SYNTHASE ALPHA CHAIN HEART ISOFORM	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ADP binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex proton-transporting ATP synthase complex membrane protein complex cation channel complex transporter complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex proton-transporting ATP synthase complex, catalytic core F(1) monoatomic ion channel complex proton-transporting ATP synthase, catalytic core cell periphery plasma membrane
D, E, F	ATP SYNTHASE BETA CHAIN	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity channel activity ligase activity	ribose phosphate metabolic process aerobic respiration cellular respiration oxidative phosphorylation ATP metabolic process energy derivation by oxidation of organic compounds ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribose phosphate metabolic process aerobic respiration cellular respiration oxidative phosphorylation ATP metabolic process energy derivation by oxidation of organic compounds ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process primary metabolic process generation of precursor metabolites and energy nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process proton motive force-driven mitochondrial ATP synthesis metabolic process cellular process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex proton-transporting ATP synthase complex membrane protein complex cation channel complex transporter complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex proton-transporting ATP synthase complex, catalytic core F(1) monoatomic ion channel complex
G	ATP SYNTHASE GAMMA CHAIN	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex proton-transporting ATP synthase complex membrane protein complex cation channel complex transporter complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex proton-transporting ATP synthase complex, catalytic core F(1) monoatomic ion channel complex
H	ATP SYNTHASE DELTA CHAIN	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity channel activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity channel activity catalytic activity ligase activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport ribose phosphate metabolic process ATP metabolic process transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process aerobic respiration cellular respiration energy derivation by oxidation of organic compounds generation of precursor metabolites and energy protein-containing complex organization mitochondrial respirasome assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly proton-transporting ATP synthase complex assembly mitochondrial proton-transporting ATP synthase complex assembly proton-transporting two-sector ATPase complex assembly protein-containing complex assembly cellular component organization or biogenesis mitochondrion organization	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex proton-transporting ATP synthase complex membrane protein complex cation channel complex transporter complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex proton-transporting ATP synthase complex, catalytic core F(1) monoatomic ion channel complex
I	ATP SYNTHASE EPSILON CHAIN	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	ribose phosphate metabolic process aerobic respiration cellular respiration oxidative phosphorylation ATP metabolic process energy derivation by oxidation of organic compounds ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribose phosphate metabolic process aerobic respiration cellular respiration oxidative phosphorylation ATP metabolic process energy derivation by oxidation of organic compounds ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process primary metabolic process generation of precursor metabolites and energy nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process proton motive force-driven mitochondrial ATP synthesis metabolic process cellular process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex proton-transporting ATP synthase complex membrane protein complex cation channel complex transporter complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex proton-transporting ATP synthase complex, catalytic core F(1) monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR038376	ATP synthase, alpha subunit, C-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
A, B, C	IPR033732	ATP synthase, F1 complex, alpha subunit nucleotide-binding domain	Domain
A, B, C	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR023366	ATP synthase subunit alpha, N-terminal domain-like superfamily	Homologous Superfamily
A, B, C	IPR000793	ATP synthase, alpha subunit, C-terminal	Domain
A, B, C	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
A, B, C	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
A, B, C	IPR005294	ATP synthase, F1 complex, alpha subunit	Family
A, B, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D, E, F	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
D, E, F	IPR024034	ATPase, F1/V1 complex, beta/alpha subunit, C-terminal	Homologous Superfamily
D, E, F	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	Homologous Superfamily
D, E, F	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
D, E, F	IPR050053	ATPase alpha/beta chains	Family
D, E, F	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
D, E, F	IPR055190	ATP synthase A/B type, C-terminal domain	Domain
D, E, F	IPR003593	AAA+ ATPase domain	Domain
D, E, F	IPR005722	ATP synthase, F1 complex, beta subunit	Family
D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G	IPR023632	ATP synthase, F1 complex, gamma subunit conserved site	Conserved Site
G	IPR000131	ATP synthase, F1 complex, gamma subunit	Family
G	IPR035968	ATP synthase, F1 complex, gamma subunit superfamily	Homologous Superfamily
H	IPR036794	ATP synthase delta/epsilon subunit, C-terminal domain superfamily	Homologous Superfamily
H	IPR020546	ATP synthase, F1 complex, delta/epsilon subunit, N-terminal	Domain
H	IPR001469	ATP synthase, F1 complex, delta/epsilon subunit	Family
H	IPR036771	F0F1 ATP synthase delta/epsilon subunit, N-terminal	Homologous Superfamily
H	IPR048937	F1F0-ATP synthase delta subunit, C-terminal domain, metazoan	Domain
I	IPR036742	ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial	Homologous Superfamily
I	IPR006721	ATP synthase, F1 complex, epsilon subunit, mitochondrial	Family