1EPF | pdb_00001epf

CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1epfa1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Neural cell adhesion molecule (NCAM)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1epfb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Neural cell adhesion molecule (NCAM)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1epfb3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d1epfc1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Neural cell adhesion molecule (NCAM)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d1epfc3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1epfd1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Neural cell adhesion molecule (NCAM)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1epfd3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	I set domains	8054758	4007543	SCOP2 (2022-06-29)
A	SCOP2 Family	I set domains	8055506	4007543	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8054759	3000071	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8055507	3000071	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055507	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054759	3000071	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055507	3000071	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054759	3000071	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054759	3000071	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055507	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	I-set_5	e1epfA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_5	ECOD (1.6)
B	I-set_5	e1epfB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_5	ECOD (1.6)
C	I-set_5	e1epfC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_5	ECOD (1.6)
D	I-set_5	e1epfD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain
A, B, C, D	PF07679	Immunoglobulin I-set domain (I-set)	Immunoglobulin I-set domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PROTEIN (NEURAL CELL ADHESION MOLECULE)	protein binding binding signaling receptor binding fibroblast growth factor receptor binding growth factor receptor binding cytoskeletal protein binding LRR domain binding protein domain specific binding phosphatase binding enzyme binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling regulation of cell communication cellular process positive regulation of signaling calcium-independent cell-cell adhesion cell adhesion cell-cell adhesion multicellular organismal process regulation of growth positive regulation of cell population proliferation regulation of developmental process regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation organ growth striated muscle tissue development positive regulation of developmental process multicellular organism development positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth anatomical structure development regulation of cardiac muscle cell proliferation muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development positive regulation of developmental growth positive regulation of heart growth system development striated muscle cell proliferation developmental process heart development heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth cardiac muscle tissue development positive regulation of organ growth growth animal organ development tissue development circulatory system development positive regulation of growth regulation of cell population proliferation positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process response to stress multicellular organismal response to stress negative regulation of programmed cell death negative regulation of cellular process negative regulation of biological process regulation of programmed cell death cell death programmed cell death trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling cellular developmental process cell differentiation mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition response to alcohol response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol cellular response to ethanol response to ethanol response to morphine response to isoquinoline alkaloid response to nitrogen compound response to alkaloid regulation of localization regulation of cellular component organization transport regulation of exocyst assembly exocyst assembly membrane docking vesicle-mediated transport cellular component biogenesis cellular component organization localization organelle localization by membrane tethering regulation of protein-containing complex assembly cellular component assembly secretion by cell organelle localization protein-containing complex assembly cellular component organization or biogenesis vesicle docking involved in exocytosis protein-containing complex organization secretion export from cell regulation of cellular component biogenesis establishment of localization exocytosis vesicle docking exocytic process regulation of vesicle docking homotypic cell-cell adhesion neuron recognition cell projection organization cell development neuron projection development neuron projection fasciculation neurogenesis neuron differentiation axonal fasciculation cell recognition plasma membrane bounded cell projection organization nervous system development axon development generation of neurons neuron development cell surface receptor signaling pathway semaphorin-plexin signaling pathway regulation of semaphorin-plexin signaling pathway regeneration response to axon injury neuron projection regeneration axon regeneration cellular response to stress response to wounding peripheral nervous system axon regeneration cellular response to fluoride response to fluoride response to activity head development forebrain development brain development diencephalon development central nervous system development thalamus development commissural neuron axon guidance axonogenesis plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis axon guidance cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron projection guidance behavior adult behavior behavioral response to ethanol biological process involved in interspecies interaction between organisms response to other organism response to external stimulus cellular response to molecule of bacterial origin response to biotic stimulus cellular response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin system process learning or memory nervous system process medium-term memory cognition memory response to metal ion response to lead ion animal organ regeneration response to oxidative stress response to cocaine	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface external side of plasma membrane side of membrane cell-cell junction cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface external side of plasma membrane side of membrane cell-cell junction anchoring junction presynapse presynaptic membrane intracellular anatomical structure cytoplasm glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body neuronal cell body axon growth cone distal axon site of polarized growth Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR009138	Neural cell adhesion	Family
A, B, C, D	IPR003599	Immunoglobulin domain subtype	Domain
A, B, C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D	IPR003598	Immunoglobulin subtype 2	Domain
A, B, C, D	IPR013098	Immunoglobulin I-set	Domain
A, B, C, D	IPR003961	Fibronectin type III	Domain
A, B, C, D	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.