1F6D | pdb_00001f6d

THE STRUCTURE OF UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE FROM E. COLI.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1f6da_	Alpha and beta proteins (a/b)	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-N-acetylglucosamine 2-epimerase	UDP-N-acetylglucosamine 2-epimerase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1f6db_	Alpha and beta proteins (a/b)	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-N-acetylglucosamine 2-epimerase	UDP-N-acetylglucosamine 2-epimerase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1f6dc_	Alpha and beta proteins (a/b)	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-N-acetylglucosamine 2-epimerase	UDP-N-acetylglucosamine 2-epimerase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1f6dd_	Alpha and beta proteins (a/b)	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-N-acetylglucosamine 2-epimerase	UDP-N-acetylglucosamine 2-epimerase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	UDP-N-acetylglucosamine 2-epimerase	8020733	4000828	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Type B glycosyltransferase-like	8033113	3001586	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Type B glycosyltransferase-like	8033113	3001586	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Type B glycosyltransferase-like	8033113	3001586	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Type B glycosyltransferase-like	8033113	3001586	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Epimerase_2_C	e1f6dA2	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Epimerase_2_C	ECOD (1.6)
A	Epimerase_2_N	e1f6dA1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Epimerase_2_N	ECOD (1.6)
B	Epimerase_2_C	e1f6dB2	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Epimerase_2_C	ECOD (1.6)
B	Epimerase_2_N	e1f6dB1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Epimerase_2_N	ECOD (1.6)
C	Epimerase_2_C	e1f6dC2	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Epimerase_2_C	ECOD (1.6)
C	Epimerase_2_N	e1f6dC1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Epimerase_2_N	ECOD (1.6)
D	Epimerase_2_C	e1f6dD1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Epimerase_2_C	ECOD (1.6)
D	Epimerase_2_N	e1f6dD2	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Epimerase_2_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)
B	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)
C	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)
D	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02350	UDP-N-acetylglucosamine 2-epimerase (Epimerase_2)	UDP-N-acetylglucosamine 2-epimerase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE	isomerase activity racemase and epimerase activity UDP-N-acetylglucosamine 2-epimerase activity racemase and epimerase activity, acting on carbohydrates and derivatives catalytic activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process enterobacterial common antigen biosynthetic process carbohydrate derivative metabolic process primary metabolic process macromolecule biosynthetic process polysaccharide metabolic process biosynthetic process enterobacterial common antigen metabolic process metabolic process cellular process macromolecule metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR032892	UDP-N-acetylglucosamine 2-epimerase WecB	Family
A, B, C, D	IPR003331	UDP-N-acetylglucosamine 2-epimerase domain	Domain
A, B, C, D	IPR029767	UDP-N-acetylglucosamine 2-epimerase WecB-like	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	UDP-N-acetylglucosamine 2-epimerase M-CSA #544	The non-hydrolysing bacterial UDP-N-acetylglucosamine 2-epimerase catalyses the conversion of UDP-N-acetylglucosamine to UDP-N-acetylmannosamine, an intermediate in the biosynthesis of several cell surface polysaccarides. The enzyme is allosterically regulated by its substrate, UDP-N-acetylglucosamine, a reaction feature specific to the bacterial form of the enzyme. The structure of the enzyme shows homology with the glycosyl transferases.	Defined by 6 residues: ASP:A-95GLU:A-117GLU:A-131HIS:A-213ARG:A-215HIS:A-246 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 5.1.3.14 (PDB Primary Data) Search M-CSA Motif + EC 5.1.3.14

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.