Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyLumazine synthase 8036909 3001085 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyLumazine synthase 8036909 3001085 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyLumazine synthase 8036909 3001085 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyLumazine synthase 8036909 3001085 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyLumazine synthase 8036909 3001085 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BDMRL_synthasee1hqkB1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Lumazine synthaseF: DMRL_synthaseECOD (1.6)
CDMRL_synthasee1hqkC1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Lumazine synthaseF: DMRL_synthaseECOD (1.6)
DDMRL_synthasee1hqkD1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Lumazine synthaseF: DMRL_synthaseECOD (1.6)
EDMRL_synthasee1hqkE1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Lumazine synthaseF: DMRL_synthaseECOD (1.6)
ADMRL_synthasee1hqkA1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Lumazine synthaseF: DMRL_synthaseECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF008856,7-dimethyl-8-ribityllumazine synthase (DMRL_synthase)6,7-dimethyl-8-ribityllumazine synthaseThis family includes the beta chain of 6,7-dimethyl-8- ribityllumazine synthase EC:2.5.1.9, an enzyme involved in riboflavin biosynthesis. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function f ...This family includes the beta chain of 6,7-dimethyl-8- ribityllumazine synthase EC:2.5.1.9, an enzyme involved in riboflavin biosynthesis. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function for example Swiss:O28856. The family contains a number of different subsets including a family of proteins comprising archaeal lumazine and riboflavin synthases, type I lumazine synthases, and the eubacterial type II lumazine synthases [1]. It has been established that lumazine synthase catalyses the penultimate step in the biosynthesis of riboflavin in plants and microorganisms. The type I lumazine synthases area active in pentameric or icosahedral quaternary assemblies, whereas the type II are decameric [2]. Brucella, a bacterial genus that causes brucellosis, and other Rhizobiales have an atypical riboflavin metabolic pathway. Brucella spp code for both a type-I and a type-II lumazine synthase, and it has been shown that at least one of these two has to be present in order for Brucella to be viable, showing that in the case of Brucella flavin metabolism is implicated in bacterial virulence [3].
Domain

InterPro: Protein Family Classification InterPro Database Homepage