1HX8 | pdb_00001hx8

CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF DROSOPHILA AP180

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1hx8b1	All alpha proteins	Spectrin repeat-like	GAT-like domain	Phosphoinositide-binding clathrin adaptor, domain 2	AP180 (Lap)	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d1hx8b2	All alpha proteins	alpha-alpha superhelix	ENTH/VHS domain	Phosphoinositide-binding clathrin adaptor, N-terminal domain	AP180 (Lap)	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
A	d1hx8a1	All alpha proteins	Spectrin repeat-like	GAT-like domain	Phosphoinositide-binding clathrin adaptor, domain 2	AP180 (Lap)	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
A	d1hx8a2	All alpha proteins	alpha-alpha superhelix	ENTH/VHS domain	Phosphoinositide-binding clathrin adaptor, N-terminal domain	AP180 (Lap)	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	GAT-like domain	8035565	3001306	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ENTH/VHS domain-like	8035567	3000164	SCOP2B (2022-06-29)
A	SCOP2 Family	Phosphoinositide-binding clathrin adaptor, domain 2	8023185	4000581	SCOP2 (2022-06-29)
A	SCOP2 Family	Phosphoinositide-binding clathrin adaptor, N-terminal domain	8023187	4000571	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GAT-like domain	8035565	3001306	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ENTH/VHS domain-like	8035567	3000164	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	ANTH_C	e1hx8B1	A: alpha bundles	X: Spectrin repeat-like	H: GAT-like domain (From Topology)	T: GAT-like domain	F: ANTH_C	ECOD (1.6)
B	ANTH_N	e1hx8B2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ANTH_N	ECOD (1.6)
A	ANTH_C	e1hx8A1	A: alpha bundles	X: Spectrin repeat-like	H: GAT-like domain (From Topology)	T: GAT-like domain	F: ANTH_C	ECOD (1.6)
A	ANTH_N	e1hx8A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ANTH_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
B	1.20.58.150	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
A	1.20.58.150	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07651	ANTH domain (ANTH)	ANTH domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	SYNAPSE-ENRICHED CLATHRIN ADAPTOR PROTEIN LAP	clathrin binding protein binding binding clathrin heavy chain binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding SNARE binding clathrin binding protein binding binding clathrin heavy chain binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding SNARE binding 1-phosphatidylinositol binding	trans-synaptic signaling regulation of biological process signaling neuron-neuron synaptic transmission biological regulation cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling cellular process response to light stimulus response to stimulus taxis trans-synaptic signaling regulation of biological process signaling neuron-neuron synaptic transmission biological regulation cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling cellular process response to light stimulus response to stimulus taxis phototaxis energy taxis response to external stimulus response to radiation response to abiotic stimulus locomotion vesicle localization establishment of organelle localization cellular localization transport establishment of vesicle localization establishment of localization localization organelle localization establishment of localization in cell synaptic vesicle localization synaptic vesicle transport import into cell vesicle budding from membrane synaptic vesicle cycle vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse cellular component organization vesicle organization synaptic vesicle recycling synaptic vesicle budding cellular component organization or biogenesis synaptic vesicle endocytosis membrane organization synaptic vesicle budding from presynaptic endocytic zone membrane organelle organization endocytosis clathrin-dependent endocytosis receptor-mediated endocytosis clathrin coat assembly cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly intracellular transport endosomal transport synaptic vesicle endosomal processing synaptic vesicle recycling via endosome clathrin-dependent synaptic vesicle endocytosis regulation of localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of biological process positive regulation of endocytosis positive regulation of receptor-mediated endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of transport positive regulation of clathrin-dependent endocytosis regulation of clathrin-dependent endocytosis	cellular anatomical structure clathrin-coated pit membrane endomembrane system membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm cellular anatomical structure clathrin-coated pit membrane endomembrane system membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm vesicle extrinsic component of plasma membrane presynaptic endocytic zone synapse plasma membrane presynaptic membrane extrinsic component of presynaptic endocytic zone membrane synaptic membrane cell periphery extrinsic component of synaptic membrane presynapse presynaptic endocytic zone membrane extrinsic component of presynaptic membrane cell junction plasma membrane region extrinsic component of membrane Golgi apparatus transport vesicle synaptic vesicle secretory vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008942	ENTH/VHS	Homologous Superfamily
A, B	IPR011417	AP180 N-terminal homology (ANTH) domain	Domain
A, B	IPR045192	Clathrin coat assembly protein AP180-like	Family
A, B	IPR014712	ANTH domain superfamily	Homologous Superfamily
A, B	IPR013809	ENTH domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.