Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
FBIRe1i3oF1 A: few secondary structure elementsX: Inhibitor of apoptosis (IAP) repeat (From Topology)H: Inhibitor of apoptosis (IAP) repeat (From Topology)T: Inhibitor of apoptosis (IAP) repeatF: BIRECOD (1.6)
EBIRe1i3oE1 A: few secondary structure elementsX: Inhibitor of apoptosis (IAP) repeat (From Topology)H: Inhibitor of apoptosis (IAP) repeat (From Topology)T: Inhibitor of apoptosis (IAP) repeatF: BIRECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
F1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1) Chain ACATH (4.3.0)
E1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1) Chain ACATH (4.3.0)
A3.40.50.1460 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
C3.40.50.1460 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
B3.30.70.1470 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Caspase-likeCATH (4.3.0)
D3.30.70.1470 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Caspase-likeCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
E, F
PF00653Inhibitor of Apoptosis domain (BIR)Inhibitor of Apoptosis domainBIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, incl ...BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin (Swiss:O15392) [2].
Domain
A, C
PF00656Caspase domain (Peptidase_C14)Caspase domain- Domain
B, D
PF00656Caspase domain (Peptidase_C14)Caspase domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
E, F
BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4
A, C
CASPASE 3
B, D
CASPASE 3

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
E, F
PharosP98170
A, C
PharosP42574
B, D
PharosP42574