1J1J | pdb_00001j1j

Crystal Structure of human Translin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d1j1jd_	All alpha proteins	alpha-alpha superhelix	Translin	Translin	Translin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1j1jc_	All alpha proteins	alpha-alpha superhelix	Translin	Translin	Translin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1j1jb_	All alpha proteins	alpha-alpha superhelix	Translin	Translin	Translin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1j1ja_	All alpha proteins	alpha-alpha superhelix	Translin	Translin	Translin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Translin	8036026	3000658	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Translin	8036026	3000658	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Translin	8036026	3000658	SCOP2B (2022-06-29)
A	SCOP2 Family	Translin	8023646	4001994	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Translin	8036026	3000658	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Translin	e1j1jD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Translin (From Topology)	T: Translin	F: Translin	ECOD (1.6)
C	Translin	e1j1jC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Translin (From Topology)	T: Translin	F: Translin	ECOD (1.6)
B	Translin	e1j1jB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Translin (From Topology)	T: Translin	F: Translin	ECOD (1.6)
A	Translin	e1j1jA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Translin (From Topology)	T: Translin	F: Translin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	1.20.58.190	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.20.58.200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.20.58.190	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.20.58.200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.190	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.20.58.190	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.20.58.200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01997	Translin family (Translin)	Translin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Translin	DNA binding binding nucleic acid binding RNA binding mRNA binding endonuclease activity nuclease activity catalytic activity, acting on a nucleic acid catalytic activity sequence-specific DNA binding identical protein binding protein binding single-stranded DNA binding	regulation of cellular process negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular process negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process siRNA processing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process post-transcriptional regulation of gene expression regulatory ncRNA-mediated post-transcriptional gene silencing post-transcriptional gene silencing	protein-containing complex endoribonuclease complex catalytic complex intracellular protein-containing complex endonuclease complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle male germ cell nucleus nucleus protein-containing complex endoribonuclease complex catalytic complex intracellular protein-containing complex endonuclease complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle male germ cell nucleus nucleus germ cell nucleus intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR016069	Translin, C-terminal	Homologous Superfamily
A, B, C, D	IPR036081	Translin superfamily	Homologous Superfamily
A, B, C, D	IPR016068	Translin, N-terminal	Homologous Superfamily
A, B, C, D	IPR002848	Translin family	Family
A, B, C, D	IPR033956	Translin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q15631	large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis lung cancer osteosarcoma plasma cell myeloma lymphoplasmacytic lymphoma ovarian cancer psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.