Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1keea1 All alpha proteins Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1keea2 Alpha and beta proteins (a/b) Methylglyoxal synthase-like Methylglyoxal synthase-like Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1keea3 Alpha and beta proteins (a/b) PreATP-grasp domain PreATP-grasp domain BC N-terminal domain-like Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1keea5 Alpha and beta proteins (a+b) ATP-grasp Glutathione synthetase ATP-binding domain-like BC ATP-binding domain-like Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ed1keee1 All alpha proteins Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ed1keee2 Alpha and beta proteins (a/b) Methylglyoxal synthase-like Methylglyoxal synthase-like Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ed1keee3 Alpha and beta proteins (a/b) PreATP-grasp domain PreATP-grasp domain BC N-terminal domain-like Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ed1keee5 Alpha and beta proteins (a+b) ATP-grasp Glutathione synthetase ATP-binding domain-like BC ATP-binding domain-like Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Cd1keec1 All alpha proteins Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Cd1keec2 Alpha and beta proteins (a/b) Methylglyoxal synthase-like Methylglyoxal synthase-like Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Cd1keec3 Alpha and beta proteins (a/b) PreATP-grasp domain PreATP-grasp domain BC N-terminal domain-like Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Cd1keec5 Alpha and beta proteins (a+b) ATP-grasp Glutathione synthetase ATP-binding domain-like BC ATP-binding domain-like Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Gd1keeg1 All alpha proteins Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, large subunit connection domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Gd1keeg2 Alpha and beta proteins (a/b) Methylglyoxal synthase-like Methylglyoxal synthase-like Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Gd1keeg3 Alpha and beta proteins (a/b) PreATP-grasp domain PreATP-grasp domain BC N-terminal domain-like Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Gd1keeg5 Alpha and beta proteins (a+b) ATP-grasp Glutathione synthetase ATP-binding domain-like BC ATP-binding domain-like Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1keeb1 Alpha and beta proteins (a/b) The 'swivelling' beta/beta/alpha domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbamoyl phosphate synthetase, small subunit N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1keeb2 Alpha and beta proteins (a/b) Flavodoxin-like Class I glutamine amidotransferase-like Class I glutamine amidotransferases (GAT) Carbamoyl phosphate synthetase, small subunit C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Fd1keef1 Alpha and beta proteins (a/b) The 'swivelling' beta/beta/alpha domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbamoyl phosphate synthetase, small subunit N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Fd1keef2 Alpha and beta proteins (a/b) Flavodoxin-like Class I glutamine amidotransferase-like Class I glutamine amidotransferases (GAT) Carbamoyl phosphate synthetase, small subunit C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Dd1keed1 Alpha and beta proteins (a/b) The 'swivelling' beta/beta/alpha domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbamoyl phosphate synthetase, small subunit N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Dd1keed2 Alpha and beta proteins (a/b) Flavodoxin-like Class I glutamine amidotransferase-like Class I glutamine amidotransferases (GAT) Carbamoyl phosphate synthetase, small subunit C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Hd1keeh1 Alpha and beta proteins (a/b) The 'swivelling' beta/beta/alpha domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbamoyl phosphate synthetase, small subunit N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Hd1keeh2 Alpha and beta proteins (a/b) Flavodoxin-like Class I glutamine amidotransferase-like Class I glutamine amidotransferases (GAT) Carbamoyl phosphate synthetase, small subunit C-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyGlutathione synthetase ATP-binding domain-like 8036563 3000094 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPreATP-grasp domain 8044232 3001680 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMethylglyoxal synthase-like 8044174 3001443 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyGlutathione synthetase ATP-binding domain-like 8036561 3000094 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPreATP-grasp domain 8044230 3001680 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCarbamoyl phosphate synthetase, large subunit connection domain 8038131 3000839 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyGlutathione synthetase ATP-binding domain-like 8036561 3000094 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyCarbamoyl phosphate synthetase, large subunit connection domain 8038131 3000839 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPreATP-grasp domain 8044232 3001680 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPreATP-grasp domain 8044230 3001680 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyMethylglyoxal synthase-like 8044174 3001443 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyGlutathione synthetase ATP-binding domain-like 8036563 3000094 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPreATP-grasp domain 8044230 3001680 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMethylglyoxal synthase-like 8044174 3001443 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyGlutathione synthetase ATP-binding domain-like 8036563 3000094 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPreATP-grasp domain 8044232 3001680 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyGlutathione synthetase ATP-binding domain-like 8036561 3000094 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCarbamoyl phosphate synthetase, large subunit connection domain 8038131 3000839 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyCarbamoyl phosphate synthetase, large subunit connection domain 8038131 3000839 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyPreATP-grasp domain 8044232 3001680 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyMethylglyoxal synthase-like 8044174 3001443 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyGlutathione synthetase ATP-binding domain-like 8036561 3000094 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyGlutathione synthetase ATP-binding domain-like 8036563 3000094 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyPreATP-grasp domain 8044230 3001680 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyClass I glutamine amidotransferase-like 8044144 3001405 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCarbamoyl phosphate synthetase, small subunit N-terminal domain 8043909 3000949 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyCarbamoyl phosphate synthetase, small subunit N-terminal domain 8043909 3000949 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyClass I glutamine amidotransferase-like 8044144 3001405 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyClass I glutamine amidotransferase-like 8044144 3001405 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyCarbamoyl phosphate synthetase, small subunit N-terminal domain 8043909 3000949 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyCarbamoyl phosphate synthetase, small subunit N-terminal domain 8043909 3000949 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyClass I glutamine amidotransferase-like 8044144 3001405 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ACPSase_L_D3e1keeA1 A: alpha arraysX: HTHH: HTHT: wingedF: CPSase_L_D3ECOD (1.6)
AATP-graspe1keeA2 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: ATP-graspF: ATP-graspECOD (1.6)
AcarBe1keeA4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: PreATP-grasp domainF: carBECOD (1.6)
AMGSe1keeA6 A: a/b three-layered sandwichesX: Methylglyoxal synthase-like (From Topology)H: Methylglyoxal synthase-like (From Topology)T: Methylglyoxal synthase-likeF: MGSECOD (1.6)
ECPSase_L_D3e1keeE1 A: alpha arraysX: HTHH: HTHT: wingedF: CPSase_L_D3ECOD (1.6)
EATP-graspe1keeE2 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: ATP-graspF: ATP-graspECOD (1.6)
EcarBe1keeE4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: PreATP-grasp domainF: carBECOD (1.6)
EMGSe1keeE6 A: a/b three-layered sandwichesX: Methylglyoxal synthase-like (From Topology)H: Methylglyoxal synthase-like (From Topology)T: Methylglyoxal synthase-likeF: MGSECOD (1.6)
CCPSase_L_D3e1keeC1 A: alpha arraysX: HTHH: HTHT: wingedF: CPSase_L_D3ECOD (1.6)
CATP-graspe1keeC2 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: ATP-graspF: ATP-graspECOD (1.6)
CcarBe1keeC4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: PreATP-grasp domainF: carBECOD (1.6)
CMGSe1keeC6 A: a/b three-layered sandwichesX: Methylglyoxal synthase-like (From Topology)H: Methylglyoxal synthase-like (From Topology)T: Methylglyoxal synthase-likeF: MGSECOD (1.6)
GCPSase_L_D3e1keeG1 A: alpha arraysX: HTHH: HTHT: wingedF: CPSase_L_D3ECOD (1.6)
GATP-graspe1keeG2 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: ATP-graspF: ATP-graspECOD (1.6)
GcarBe1keeG4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: PreATP-grasp domainF: carBECOD (1.6)
GMGSe1keeG6 A: a/b three-layered sandwichesX: Methylglyoxal synthase-like (From Topology)H: Methylglyoxal synthase-like (From Topology)T: Methylglyoxal synthase-likeF: MGSECOD (1.6)
BGATasee1keeB1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Class I glutamine amidotransferase-likeF: GATaseECOD (1.6)
BCPSase_sm_chaine1keeB2 A: a/b three-layered sandwichesX: The swivelling beta/beta/alpha domainsH: The swivelling beta/beta/alpha domain (From Topology)T: The swivelling beta/beta/alpha domainF: CPSase_sm_chainECOD (1.6)
FGATasee1keeF1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Class I glutamine amidotransferase-likeF: GATaseECOD (1.6)
FCPSase_sm_chaine1keeF2 A: a/b three-layered sandwichesX: The swivelling beta/beta/alpha domainsH: The swivelling beta/beta/alpha domain (From Topology)T: The swivelling beta/beta/alpha domainF: CPSase_sm_chainECOD (1.6)
DGATasee1keeD1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Class I glutamine amidotransferase-likeF: GATaseECOD (1.6)
DCPSase_sm_chaine1keeD2 A: a/b three-layered sandwichesX: The swivelling beta/beta/alpha domainsH: The swivelling beta/beta/alpha domain (From Topology)T: The swivelling beta/beta/alpha domainF: CPSase_sm_chainECOD (1.6)
HGATasee1keeH1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Class I glutamine amidotransferase-likeF: GATaseECOD (1.6)
HCPSase_sm_chaine1keeH2 A: a/b three-layered sandwichesX: The swivelling beta/beta/alpha domainsH: The swivelling beta/beta/alpha domain (From Topology)T: The swivelling beta/beta/alpha domainF: CPSase_sm_chainECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.20 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
A3.30.470.20 Alpha Beta 2-Layer Sandwich D-amino Acid Aminotransferase Chain A, domain 1CATH (4.3.0)
A3.30.1490.20 Alpha Beta 2-Layer Sandwich Dna Ligase domain 1CATH (4.3.0)
A1.10.1030.10 Mainly Alpha Orthogonal Bundle Carbamoyl Phosphate Synthetase Chain A, domain 4CATH (4.3.0)
A3.40.50.1380 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Methylglyoxal synthase-like domainCATH (4.3.0)
E3.40.50.20 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
E3.30.470.20 Alpha Beta 2-Layer Sandwich D-amino Acid Aminotransferase Chain A, domain 1CATH (4.3.0)
E3.30.1490.20 Alpha Beta 2-Layer Sandwich Dna Ligase domain 1CATH (4.3.0)
E1.10.1030.10 Mainly Alpha Orthogonal Bundle Carbamoyl Phosphate Synthetase Chain A, domain 4CATH (4.3.0)
E3.40.50.1380 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Methylglyoxal synthase-like domainCATH (4.3.0)
C3.40.50.20 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
C3.30.470.20 Alpha Beta 2-Layer Sandwich D-amino Acid Aminotransferase Chain A, domain 1CATH (4.3.0)
C3.30.1490.20 Alpha Beta 2-Layer Sandwich Dna Ligase domain 1CATH (4.3.0)
C1.10.1030.10 Mainly Alpha Orthogonal Bundle Carbamoyl Phosphate Synthetase Chain A, domain 4CATH (4.3.0)
C3.40.50.1380 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Methylglyoxal synthase-like domainCATH (4.3.0)
G3.40.50.20 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
G3.30.470.20 Alpha Beta 2-Layer Sandwich D-amino Acid Aminotransferase Chain A, domain 1CATH (4.3.0)
G3.30.1490.20 Alpha Beta 2-Layer Sandwich Dna Ligase domain 1CATH (4.3.0)
G1.10.1030.10 Mainly Alpha Orthogonal Bundle Carbamoyl Phosphate Synthetase Chain A, domain 4CATH (4.3.0)
G3.40.50.1380 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Methylglyoxal synthase-like domainCATH (4.3.0)
B3.50.30.20 Alpha Beta 3-Layer(bba) Sandwich Glucose Oxidase domain 1CATH (4.3.0)
B3.40.50.880 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Class I glutamine amidotransferase (GATase) domainCATH (4.3.0)
F3.50.30.20 Alpha Beta 3-Layer(bba) Sandwich Glucose Oxidase domain 1CATH (4.3.0)
F3.40.50.880 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Class I glutamine amidotransferase (GATase) domainCATH (4.3.0)
D3.50.30.20 Alpha Beta 3-Layer(bba) Sandwich Glucose Oxidase domain 1CATH (4.3.0)
D3.40.50.880 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Class I glutamine amidotransferase (GATase) domainCATH (4.3.0)
H3.50.30.20 Alpha Beta 3-Layer(bba) Sandwich Glucose Oxidase domain 1CATH (4.3.0)
H3.40.50.880 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Class I glutamine amidotransferase (GATase) domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C, E, G
PF02142MGS-like domain (MGS)MGS-like domainThis domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the allosteric effector ornithine. This family also includes ino ...This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the allosteric effector ornithine. This family also includes inosicase. The known structures in this family show a common phosphate binding site [1].
Domain
A, C, E, G
PF02786Carbamoyl-phosphate synthase L chain, ATP binding domain (CPSase_L_D2)Carbamoyl-phosphate synthase L chain, ATP binding domainCarbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [2]. The c ...Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [2]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117. The ATP binding domain (this one) has an ATP-grasp fold.
Domain
A, C, E, G
PF02787Carbamoyl-phosphate synthetase large chain, oligomerisation domain (CPSase_L_D3)Carbamoyl-phosphate synthetase large chain, oligomerisation domainCarbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain.Domain
B, D, F, H
PF00117Glutamine amidotransferase class-I (GATase)Glutamine amidotransferase class-I- Domain
B, D, F, H
PF00988Carbamoyl-phosphate synthase small chain, CPSase domain (CPSase_sm_chain)Carbamoyl-phosphate synthase small chain, CPSase domainThe carbamoyl-phosphate synthase domain is in the amino terminus of protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both ...The carbamoyl-phosphate synthase domain is in the amino terminus of protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [1]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00289. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117.
Domain
B, D, F, H
PF07722Peptidase C26 (Peptidase_C26)Peptidase C26These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C ...These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C terminus [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E, G
Carbamoyl-phosphate synthetase large chain
B, D, F, H
Carbamoyl-phosphate synthetase small chain