1L8O | pdb_00001l8o

Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1l8oa_	Alpha and beta proteins (a/b)	HAD-like	HAD-like	Phosphoserine phosphatase	Phosphoserine phosphatase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1l8ob_	Alpha and beta proteins (a/b)	HAD-like	HAD-like	Phosphoserine phosphatase	Phosphoserine phosphatase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	HAD-like	8033471	3001890	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HAD-like	8033471	3001890	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HAD	e1l8oA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: HAD	ECOD (1.6)
B	HAD	e1l8oB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: HAD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
A	1.10.150.210	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
B	1.10.150.210	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00702	haloacid dehalogenase-like hydrolase (Hydrolase)	haloacid dehalogenase-like hydrolase	This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted fo ...	This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	L-3-phosphoserine phosphatase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity L-phosphoserine phosphatase activity catalytic activity	response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus response to ketone response to lipid response to chemical response to oxygen-containing compound response to testosterone response to nutrient levels serine family amino acid metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus response to ketone response to lipid response to chemical response to oxygen-containing compound response to testosterone response to nutrient levels serine family amino acid metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process L-serine metabolic process alpha-amino acid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process metabolic process cellular process small molecule metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development organic acid biosynthetic process carboxylic acid biosynthetic process small molecule biosynthetic process L-amino acid biosynthetic process L-serine biosynthetic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process serine family amino acid biosynthetic process alpha-amino acid biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR023214	HAD superfamily	Homologous Superfamily
A, B	IPR050582	HAD-like hydrolase superfamily, SerB	Family
A, B	IPR036412	HAD-like superfamily	Homologous Superfamily
A, B	IPR004469	Phosphoserine phosphatase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P78330	PSPH deficiency malignant pancreatic neoplasm non-small cell lung carcinoma adenoma Amino Acid Metabolism, Inherited Disorders atypical teratoid rhabdoid tumor heart disease intellectual disability malignant ependymoma medulloblastoma oligodendroglioma sinusitis adrenal cortex carcinoma astrocytic tumor breast cancer PSPH deficiency malignant pancreatic neoplasm non-small cell lung carcinoma adenoma Amino Acid Metabolism, Inherited Disorders atypical teratoid rhabdoid tumor heart disease intellectual disability malignant ependymoma medulloblastoma oligodendroglioma sinusitis adrenal cortex carcinoma astrocytic tumor breast cancer exocrine pancreatic carcinoma inborn serine deficiency lung cancer malignant glioma nasopharyngeal carcinoma psoriasis atopic eczema ductal breast carcinoma in situ glioblastoma inherited amino acid metabolic disorder malignant colon neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.