1N3T | pdb_00001n3t

Biosynthesis of pteridins. Reaction mechanism of GTP cyclohydrolase I

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth I]	d1n3ti_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
K [auth A]	d1n3ta_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
O [auth E]	d1n3te_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
N [auth D]	d1n3td_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
M [auth C]	d1n3tc_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
L [auth B]	d1n3tb_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
J [auth O]	d1n3to_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
I [auth N]	d1n3tn_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H [auth M]	d1n3tm_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G [auth L]	d1n3tl_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F [auth K]	d1n3tk_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E [auth J]	d1n3tj_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C [auth H]	d1n3th_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B [auth G]	d1n3tg_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A [auth F]	d1n3tf_	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	GTP cyclohydrolase I	GTP cyclohydrolase I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth I]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
K [auth A]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
O [auth E]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
N [auth D]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
M [auth C]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
L [auth B]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
J [auth O]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
I [auth N]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
H [auth M]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
G [auth L]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
F [auth K]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
E [auth J]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
C [auth H]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
B [auth G]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)
A [auth F]	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8035783	3000283	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth I]	GTP_cyclohydroI	e1n3tI1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
K [auth A]	GTP_cyclohydroI	e1n3tA1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
O [auth E]	GTP_cyclohydroI	e1n3tE1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
N [auth D]	GTP_cyclohydroI	e1n3tD1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
M [auth C]	GTP_cyclohydroI	e1n3tC1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
L [auth B]	GTP_cyclohydroI	e1n3tB1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
J [auth O]	GTP_cyclohydroI	e1n3tO1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
I [auth N]	GTP_cyclohydroI	e1n3tN1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
H [auth M]	GTP_cyclohydroI	e1n3tM1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
G [auth L]	GTP_cyclohydroI	e1n3tL1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
F [auth K]	GTP_cyclohydroI	e1n3tK1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
E [auth J]	GTP_cyclohydroI	e1n3tJ1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
C [auth H]	GTP_cyclohydroI	e1n3tH1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
B [auth G]	GTP_cyclohydroI	e1n3tG1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)
A [auth F]	GTP_cyclohydroI	e1n3tF1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: GTP_cyclohydroI	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth I]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
D [auth I]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
K [auth A]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
K [auth A]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
O [auth E]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
O [auth E]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
N [auth D]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
N [auth D]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
M [auth C]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
M [auth C]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
L [auth B]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
L [auth B]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
J [auth O]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
J [auth O]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
I [auth N]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
I [auth N]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
H [auth M]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
H [auth M]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
G [auth L]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
G [auth L]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
F [auth K]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
F [auth K]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
E [auth J]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
E [auth J]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
C [auth H]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
C [auth H]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
B [auth G]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
B [auth G]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)
A [auth F]	1.10.286.10	Mainly Alpha	Orthogonal Bundle	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
A [auth F]	3.30.1130.10	Alpha Beta	2-Layer Sandwich	GTP Cyclohydrolase I, domain 2	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], F [auth K], G [auth L], H [auth M], I [auth N], J [auth O], K [auth A], L [auth B], M [auth C], N [auth D], O [auth E]	PF01227	GTP cyclohydrolase I (GTP_cyclohydroI)	GTP cyclohydrolase I	This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins including Swiss:Q46920.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], F [auth K], G [auth L], H [auth M], I [auth N], J [auth O], K [auth A], L [auth B], M [auth C], N [auth D], O [auth E]	GTP cyclohydrolase I	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GTP cyclohydrolase activity cyclohydrolase activity hydrolase activity GTP cyclohydrolase I activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GTP cyclohydrolase activity cyclohydrolase activity hydrolase activity GTP cyclohydrolase I activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding identical protein binding protein binding	tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA queuosine(34) biosynthetic process tRNA wobble guanine modification tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA queuosine(34) biosynthetic process tRNA wobble guanine modification tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing macromolecule modification metabolic process cellular process tRNA wobble base modification macromolecule metabolic process RNA processing small molecule metabolic process one-carbon metabolic process polyol metabolic process small molecule biosynthetic process alcohol metabolic process diol biosynthetic process diol metabolic process tetrahydrobiopterin biosynthetic process tetrahydrobiopterin metabolic process pteridine-containing compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process pteridine-containing compound metabolic process folic acid-containing compound biosynthetic process modified amino acid biosynthetic process modified amino acid metabolic process folic acid-containing compound metabolic process tetrahydrofolate biosynthetic process tetrahydrofolate metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], F [auth K], G [auth L], H [auth M], I [auth N], J [auth O], K [auth A], L [auth B], M [auth C], N [auth D], O [auth E]	IPR020602	GTP cyclohydrolase I domain	Domain
A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], F [auth K], G [auth L], H [auth M], I [auth N], J [auth O], K [auth A], L [auth B], M [auth C], N [auth D], O [auth E]	IPR043133	GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase	Homologous Superfamily
A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], F [auth K], G [auth L], H [auth M], I [auth N], J [auth O], K [auth A], L [auth B], M [auth C], N [auth D], O [auth E]	IPR043134	GTP cyclohydrolase I, N-terminal domain	Homologous Superfamily
A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], F [auth K], G [auth L], H [auth M], I [auth N], J [auth O], K [auth A], L [auth B], M [auth C], N [auth D], O [auth E]	IPR018234	GTP cyclohydrolase I, conserved site	Conserved Site
A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], A [auth F], B [auth G], C [auth H], D [auth I], E [auth J], F [auth K], G [auth L], H [auth M], I [auth N], J [auth O], K [auth A], L [auth B], M [auth C], N [auth D], O [auth E]	IPR001474	GTP cyclohydrolase I	Family