1RY7 | pdb_00001ry7

Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ry7a_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	Acidic FGF (FGF1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1ry7b1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Fibroblast growth factor receptor, FGFR	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cytokine	8042239	3000648	SCOP2B (2022-06-29)
B	SCOP2 Family	I set domains	8054788	4007543	SCOP2 (2022-06-29)
B	SCOP2 Family	I set domains	8055567	4007543	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8054789	3000071	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8055568	3000071	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FGF	e1ry7A1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
B	I-set	e1ry7B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00167	Fibroblast growth factor (FGF)	Fibroblast growth factor	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, c ...	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerisation of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular [2]. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms [2].	Domain
B	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain
B	PF07679	Immunoglobulin I-set domain (I-set)	Immunoglobulin I-set domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Heparin-binding growth factor 1	protein binding binding signaling receptor binding fibroblast growth factor receptor binding growth factor receptor binding molecular transducer activity molecular function activator activity signaling receptor activity growth factor activity signaling receptor activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity Hsp70 protein binding protein binding binding signaling receptor binding fibroblast growth factor receptor binding growth factor receptor binding molecular transducer activity molecular function activator activity signaling receptor activity growth factor activity signaling receptor activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity Hsp70 protein binding protein-folding chaperone binding heat shock protein binding S100 protein binding cell adhesion molecule binding protein-containing complex binding integrin binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	multicellular organismal process mesonephric epithelium development kidney epithelium development nephron morphogenesis developmental growth branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis ureteric bud elongation nephron tubule development renal system development multicellular organism development ureteric bud morphogenesis tube morphogenesis branch elongation involved in ureteric bud branching multicellular organismal process mesonephric epithelium development kidney epithelium development nephron morphogenesis developmental growth branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis ureteric bud elongation nephron tubule development renal system development multicellular organism development ureteric bud morphogenesis tube morphogenesis branch elongation involved in ureteric bud branching branching involved in ureteric bud morphogenesis anatomical structure development renal tubule development animal organ morphogenesis epithelial tube morphogenesis nephron development system development nephron epithelium development developmental process ureteric bud development epithelium development axis elongation tube development mesonephros development branch elongation of an epithelium animal organ development growth morphogenesis of an epithelium tissue development developmental growth involved in morphogenesis tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis morphogenesis of a branching epithelium neurogenesis cellular developmental process cell differentiation cellular process nervous system development positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process endothelial cell migration biological regulation positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion positive regulation of cellular process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling blood vessel morphogenesis angiogenesis vasculature development circulatory system development anatomical structure formation involved in morphogenesis blood vessel development response to fibroblast growth factor cellular response to growth factor stimulus regulation of response to external stimulus endothelial cell chemotaxis to fibroblast growth factor cellular response to endogenous stimulus taxis endothelial cell chemotaxis regulation of cell chemotaxis to fibroblast growth factor cell chemotaxis chemotaxis regulation of endothelial cell chemotaxis to fibroblast growth factor regulation of endothelial cell chemotaxis response to endogenous stimulus regulation of cellular response to growth factor stimulus response to external stimulus regulation of chemotaxis cellular response to chemical stimulus response to chemical cell chemotaxis to fibroblast growth factor response to growth factor cellular response to fibroblast growth factor stimulus regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process activation of protein kinase B activity positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity primary metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process cellular response to heat cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus regulation of steroid biosynthetic process regulation of cholesterol biosynthetic process regulation of cholesterol metabolic process steroid metabolic process regulation of lipid metabolic process sterol metabolic process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process regulation of small molecule metabolic process positive regulation of biosynthetic process positive regulation of lipid metabolic process small molecule metabolic process steroid biosynthetic process regulation of biosynthetic process secondary alcohol biosynthetic process regulation of alcohol biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process cholesterol biosynthetic process positive regulation of cholesterol biosynthetic process secondary alcohol metabolic process positive regulation of steroid biosynthetic process biosynthetic process sterol biosynthetic process positive regulation of lipid biosynthetic process regulation of sterol biosynthetic process alcohol biosynthetic process positive regulation of cholesterol metabolic process positive regulation of steroid metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process positive regulation of alcohol biosynthetic process positive regulation of sterol biosynthetic process lipid metabolic process respiratory tube development lung development respiratory system development positive regulation of cell division cell division regulation of cell division regulation of developmental process endothelium development morphogenesis of an endothelium endothelial tube morphogenesis regulation of endothelial tube morphogenesis regulation of morphogenesis of an epithelium regulation of anatomical structure morphogenesis cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of MAP kinase activity regulation of protein serine/threonine kinase activity regulation of hepatocyte proliferation gland development liver development gland morphogenesis epithelial cell proliferation liver morphogenesis positive regulation of epithelial cell proliferation epithelial cell proliferation involved in liver morphogenesis hepatocyte proliferation hepaticobiliary system development positive regulation of hepatocyte proliferation regulation of epithelial cell proliferation cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway fibroblast growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of vasculature development positive regulation of developmental process regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process wound healing response to wounding regulation of sprouting angiogenesis positive regulation of sprouting angiogenesis sprouting angiogenesis specification of animal organ identity pattern specification process developmental induction animal organ formation regulation of animal organ morphogenesis regionalization positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular matrix external encapsulating structure membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular matrix external encapsulating structure membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen extracellular region extracellular space
B	Fibroblast growth factor receptor 3	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity GPI-linked ephrin receptor activity protein-hormone receptor activity insulin receptor activity histone H3Y41 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity placental growth factor receptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding fibroblast growth factor binding protein binding growth factor binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity brain-derived neurotrophic factor receptor activity neurotrophin receptor activity insulin-like growth factor receptor activity hepatocyte growth factor receptor activity identical protein binding boss receptor activity epidermal growth factor receptor activity macrophage colony-stimulating factor receptor activity platelet-derived growth factor alpha-receptor activity fibroblast growth factor receptor activity vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone H2AX kinase activity	developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development multicellular organism development skeletal system development system development cellular response to stimulus response to fibroblast growth factor regulation of cellular process developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development multicellular organism development skeletal system development system development cellular response to stimulus response to fibroblast growth factor regulation of cellular process cellular response to growth factor stimulus response to stimulus signaling fibroblast growth factor receptor apoptotic signaling pathway extrinsic apoptotic signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of biological process cell surface receptor signaling pathway response to endogenous stimulus biological regulation cell death apoptotic signaling pathway fibroblast growth factor receptor signaling pathway cellular process apoptotic process response to growth factor programmed cell death cellular response to fibroblast growth factor stimulus cell-cell signaling endochondral ossification replacement ossification endochondral bone morphogenesis anatomical structure morphogenesis skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process negative regulation of biological process growth negative regulation of developmental growth negative regulation of growth intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of phospholipase activity regulation of molecular function positive regulation of molecular function positive regulation of hydrolase activity positive regulation of phospholipase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity positive regulation of lipase activity cell population proliferation chondrocyte proliferation cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT organ growth bone growth endochondral bone growth cellular developmental process connective tissue development cell differentiation chondrocyte differentiation cartilage development bone maturation developmental maturation anatomical structure maturation animal organ maturation positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of phosphorylation positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification metabolic process regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation regulation of macromolecule metabolic process positive regulation of tyrosine phosphorylation of STAT protein regulation of phosphorylation peptidyl-tyrosine phosphorylation	protein-containing complex receptor complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cell surface cell periphery plasma membrane protein-containing complex receptor complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cell surface cell periphery plasma membrane membrane transport vesicle intracellular vesicle cytoplasmic vesicle vesicle extracellular region endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008996	Cytokine IL1/FGF	Homologous Superfamily
A	IPR002209	Fibroblast growth factor family	Family
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR008266	Tyrosine-protein kinase, active site	Active Site
B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
B	IPR000719	Protein kinase domain	Domain
B	IPR003599	Immunoglobulin domain subtype	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR017441	Protein kinase, ATP binding site	Binding Site
B	IPR003598	Immunoglobulin subtype 2	Domain
B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B	IPR013098	Immunoglobulin I-set	Domain
B	IPR016248	Fibroblast growth factor receptor family	Family
B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B	IPR050122	Receptor Tyrosine Kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P05230	Weight Gain leukemia ovarian cancer pulmonary fibrosis medulloblastoma osteosarcoma pituitary cancer atypical teratoid rhabdoid tumor breast carcinoma Down syndrome heart disease idiopathic interstitial pneumonia malignant mesothelioma mesothelioma primitive neuroectodermal tumor Weight Gain leukemia ovarian cancer pulmonary fibrosis medulloblastoma osteosarcoma pituitary cancer atypical teratoid rhabdoid tumor breast carcinoma Down syndrome heart disease idiopathic interstitial pneumonia malignant mesothelioma mesothelioma primitive neuroectodermal tumor benign mesothelioma coronary artery disease ductal breast carcinoma in situ invasive ductal breast carcinoma lung carcinoma myocardial ischemia ovarian neoplasm breast cancer cystic fibrosis hypotensive disorder large cell medulloblastoma malignant ependymoma
B	Pharos: P22607	achondroplasia hypochondroplasia LADD syndrome plasma cell myeloma thanatophoric dysplasia Muenke syndrome testicular germ cell tumor severe achondroplasia-developmental delay-acanthosis nigricans syndrome urinary bladder cancer seborrheic keratosis Crouzon syndrome-acanthosis nigricans syndrome nevus, epidermal thanatophoric dysplasia type 2 cervical cancer craniosynostosis achondroplasia hypochondroplasia LADD syndrome plasma cell myeloma thanatophoric dysplasia Muenke syndrome testicular germ cell tumor severe achondroplasia-developmental delay-acanthosis nigricans syndrome urinary bladder cancer seborrheic keratosis Crouzon syndrome-acanthosis nigricans syndrome nevus, epidermal thanatophoric dysplasia type 2 cervical cancer craniosynostosis camptodactyly-tall stature-scoliosis-hearing loss syndrome thanatophoric dysplasia type 1 transitional cell carcinoma Saethre-Chotzen syndrome seminoma gliosarcoma colorectal cancer giant cell glioblastoma cleft palate spermatocytic seminoma testicular seminoma Malignant neoplasm of common bile duct (& [carcinoma]) medulloblastoma colorectal carcinoma glioblastoma oligodendroglioma arthrogryposis urinary bladder carcinoma interstitial cystitis osteogenesis imperfecta bladder benign neoplasm invasive ductal breast carcinoma pilocytic astrocytoma breast cancer yolk sac tumor isolated plagiocephaly cancer lung adenocarcinoma psoriasis choanal atresia malignant glioma malignant pancreatic neoplasm colorectal adenocarcinoma myeloid neoplasm non-small cell lung carcinoma ulcerative colitis idiopathic pulmonary fibrosis osteoarthritis atypical teratoid rhabdoid tumor urinary bladder disease osteosarcoma bladder carcinoma in situ uterine cervix carcinoma in situ inverted follicular keratosis pituitary cancer breast carcinoma plasma cell neoplasm cleft lip malignant mesothelioma mucopolysaccharidosis type 4 cutaneous lupus erythematosus hydrocephalus nongerminomatous germ cell tumor acrocephalosyndactyly intellectual disability osteochondrodysplasia biliary tract cancer urinary bladder neoplasm interstitial lung disease pancreatic ductal adenocarcinoma woolly hair nevus isolated brachycephaly large cell medulloblastoma polydactyly cervical carcinoma malignant colon neoplasm renal cell carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.