1SL6

Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1sl6b_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	DC-SIGNR (DC-SIGN related receptor)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1sl6c_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	DC-SIGNR (DC-SIGN related receptor)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1sl6d_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	DC-SIGNR (DC-SIGN related receptor)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1sl6e_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	DC-SIGNR (DC-SIGN related receptor)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1sl6f_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	DC-SIGNR (DC-SIGN related receptor)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1sl6a_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	DC-SIGNR (DC-SIGN related receptor)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	C-type lectin-like	8033852	3001261	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C-type lectin-like	8033852	3001261	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	C-type lectin-like	8033852	3001261	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	C-type lectin-like	8033852	3001261	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	C-type lectin-like	8033852	3001261	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	C-type lectin-like	8033852	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Lectin_C	e1sl6B1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
C	Lectin_C	e1sl6C1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
D	Lectin_C	e1sl6D1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
E	Lectin_C	e1sl6E1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
F	Lectin_C	e1sl6F1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
A	Lectin_C	e1sl6A1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
C	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
D	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
E	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
F	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
A	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	C-type lectin DC-SIGNR	protein binding binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity antigen binding peptide antigen binding peptide binding ICAM-3 receptor activity transmembrane signaling receptor activity carbohydrate binding D-mannose binding monosaccharide binding protein binding binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity antigen binding peptide antigen binding peptide binding ICAM-3 receptor activity transmembrane signaling receptor activity carbohydrate binding D-mannose binding monosaccharide binding small molecule binding calcium-dependent protein binding cation binding ion binding metal ion binding virion binding	peptide transport antigen processing and presentation localization nitrogen compound transport amide transport transport immune system process antigen processing and presentation of peptide antigen establishment of localization peptide antigen transport response to stimulus immune response adaptive immune response import into cell peptide transport antigen processing and presentation localization nitrogen compound transport amide transport transport immune system process antigen processing and presentation of peptide antigen establishment of localization peptide antigen transport response to stimulus immune response adaptive immune response import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms viral life cycle biological process involved in interaction with host vesicle-mediated transport biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host cellular process endocytosis involved in viral entry into host cell endocytosis receptor-mediated endocytosis transport of virus viral genome replication response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus intracellular transport of virus virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host cell-cell recognition cell recognition cell adhesion cell-cell adhesion leukocyte cell-cell adhesion cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation signal transduction intracellular signal transduction cell communication	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm host cellular component host cell extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR016187	C-type lectin fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR033989	CD209-like, C-type lectin-like domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR001304	C-type lectin-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR051004	Dendritic cell-specific ICAM-grabbing non-integrin domain-containing protein	Family
A, B, C, D, E A, B, C, D, E, F	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR018378	C-type lectin, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9H2X3	hepatocellular carcinoma ovarian cancer MALT lymphoma pancreatic ductal adenocarcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.