1SRA | pdb_00001sra

STRUCTURE OF A NOVEL EXTRACELLULAR CA2+-BINDING MODULE IN BM-40(SLASH)SPARC(SLASH)OSTEONECTIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1sraa_	All alpha proteins	EF Hand-like	EF-hand	Osteonectin	C-terminal (EC) domain of BM-40/SPARC/osteonectin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8037302	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SPARC_Ca_bdg	e1sraA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: SPARC_Ca_bdg	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10591	Secreted protein acidic and rich in cysteine Ca binding region (SPARC_Ca_bdg)	Secreted protein acidic and rich in cysteine Ca binding region	The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each c ...	The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SPARC	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding extracellular matrix binding collagen binding protein-containing complex binding	positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process endothelial cell migration biological regulation positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process endothelial cell migration biological regulation positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cellular process cell motility locomotion positive regulation of cellular process developmental process anatomical structure morphogenesis regulation of developmental process anatomical structure development cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis regulation of cellular component organization cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality ear morphogenesis embryonic organ morphogenesis multicellular organismal process ear development sensory organ development tube development semicircular canal morphogenesis animal organ development embryonic morphogenesis embryo development multicellular organism development tube morphogenesis semicircular canal development sensory organ morphogenesis inner ear development inner ear morphogenesis animal organ morphogenesis embryonic organ development negative regulation of biological process angiogenesis regulation of vasculature development regulation of multicellular organismal process system development blood vessel development regulation of multicellular organismal development blood vessel morphogenesis negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process negative regulation of cell population proliferation cell population proliferation endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation negative regulation of cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen nuclear matrix basement membrane cell periphery membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen nuclear matrix basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cell surface plasma membrane membrane cytoplasm platelet alpha granule membrane intracellular vesicle endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle vesicle organelle membrane platelet alpha granule secretory granule membrane extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen platelet alpha granule lumen endocytic vesicle lumen endocytic vesicle extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015369	Follistatin/Osteonectin EGF domain	Domain
A	IPR036058	Kazal domain superfamily	Homologous Superfamily
A	IPR002350	Kazal domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR037641	SPARC, follistatin-like domain	Domain
A	IPR003645	Follistatin-like, N-terminal	Domain
A	IPR001999	Osteonectin-like, conserved site	Conserved Site
A	IPR019577	SPARC/Testican, calcium-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P09486	osteogenesis imperfecta osteogenesis imperfecta type 17 acute myeloid leukemia plasma cell myeloma adrenal cortex carcinoma uremia Hyperalgesia colorectal cancer hepatitis osteogenesis imperfecta type 4 intervertebral disc degenerative disorder kidney disease cirrhosis of liver malignant colon neoplasm ovarian cancer osteogenesis imperfecta osteogenesis imperfecta type 17 acute myeloid leukemia plasma cell myeloma adrenal cortex carcinoma uremia Hyperalgesia colorectal cancer hepatitis osteogenesis imperfecta type 4 intervertebral disc degenerative disorder kidney disease cirrhosis of liver malignant colon neoplasm ovarian cancer thrombocytopenia malignant pancreatic neoplasm mucopolysaccharidosis type 4 Emery-Dreifuss muscular dystrophy nasopharyngeal carcinoma oligodendroglioma glioblastoma ovarian neoplasm adrenal carcinoma pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor juvenile dermatomyositis limb-girdle muscular dystrophy Becker muscular dystrophy pterygium chronic kidney disease subependymal giant cell astrocytoma malignant glioma transitional cell carcinoma coronary artery disease Down syndrome myeloid neoplasm esophageal adenocarcinoma gastric cancer osteochondrodysplasia pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atopic eczema plasma cell neoplasm benign colon neoplasm colorectal carcinoma ulcerative colitis cystic fibrosis medulloblastoma Duchenne muscular dystrophy myocardial ischemia exocrine pancreatic carcinoma gastric carcinoma hepatocellular carcinoma pancreatic intraductal papillary-mucinous carcinoma invasive ductal breast carcinoma large cell medulloblastoma pilocytic astrocytoma atypical teratoid rhabdoid tumor primitive neuroectodermal tumor breast cancer Sjogren syndrome colonic neoplasm malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.