Annotations: 1UJL

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ujla_	Peptides	Inactivation gate of potassium and sodium channels	Inactivation gate of potassium and sodium channels	Inactivation gate of potassium and sodium channels	Potassium voltage-gated channel subfamily H (HERG) extracellular linker	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Potassium voltage-gated channel subfamily H member 2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding scaffold protein binding protein binding monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding scaffold protein binding protein binding monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization delayed rectifier potassium channel activity identical protein binding protein homodimerization activity protein dimerization activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding inward rectifier potassium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity ligand-gated monoatomic cation channel activity	transport monoatomic ion transmembrane transport potassium ion transmembrane transport establishment of localization metal ion transport monoatomic cation transmembrane transport transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport regulation of biological process membrane repolarization transport monoatomic ion transmembrane transport potassium ion transmembrane transport establishment of localization metal ion transport monoatomic cation transmembrane transport transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport regulation of biological process membrane repolarization regulation of membrane repolarization biological regulation regulation of biological quality regulation of membrane potential heart process multicellular organismal process regulation of heart rate by chemical signal system process regulation of heart contraction regulation of system process circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction regulation of heart rate by hormone blood circulation regulation of heart rate cardiac muscle cell membrane repolarization ventricular cardiac muscle cell membrane repolarization regulation of cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of localization regulation of potassium ion transport regulation of cellular process negative regulation of monoatomic ion transport negative regulation of biological process negative regulation of transport regulation of monoatomic ion transmembrane transport negative regulation of transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process negative regulation of cation transmembrane transport regulation of metal ion transport negative regulation of potassium ion transport regulation of transport regulation of monoatomic ion transport negative regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport membrane depolarization during action potential membrane depolarization action potential export from cell export across plasma membrane potassium ion export across plasma membrane membrane repolarization during action potential cardiac muscle cell action potential involved in contraction membrane repolarization during cardiac muscle cell action potential cardiac muscle contraction striated muscle contraction actin filament-based process cardiac muscle cell contraction ventricular cardiac muscle cell action potential actin filament-based movement muscle contraction muscle system process membrane repolarization during ventricular cardiac muscle cell action potential cardiac muscle cell action potential actin-mediated cell contraction potassium ion homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis monoatomic cation homeostasis positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus negative regulation of potassium ion export across plasma membrane regulation of potassium ion export across plasma membrane import into cell import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane potassium ion import across plasma membrane positive regulation of cation transmembrane transport positive regulation of monoatomic ion transport positive regulation of transmembrane transport positive regulation of monoatomic ion transmembrane transport positive regulation of potassium ion transport positive regulation of transport positive regulation of potassium ion transmembrane transport cardiac conduction regulation of heart rate by cardiac conduction	cell surface cellular anatomical structure cell periphery plasma membrane membrane voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex cell surface cellular anatomical structure cell periphery plasma membrane membrane voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex intracellular anatomical structure perinuclear region of cytoplasm cytoplasm inward rectifier potassium channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A	IPR000700	PAS-associated, C-terminal	Domain
A	IPR005821	Ion transport domain	Domain
A	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG-like	Family
A	IPR000014	PAS domain	Domain
A	IPR000595	Cyclic nucleotide-binding domain	Domain
A	IPR003967	Potassium channel, voltage-dependent, ERG	Family
A	IPR035965	PAS domain superfamily	Homologous Superfamily
A	IPR001610	PAC motif	Repeat
A	IPR050818	Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type	Family
A	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q12809	long QT syndrome long QT syndrome 2 short QT syndrome type 1 muscular atrophy atrial fibrillation torsades de pointes malignant colon neoplasm Brugada syndrome short QT syndrome cancer familial atrial fibrillation schizophrenia subependymal giant cell astrocytoma hypertensive disorder ventricular fibrillation long QT syndrome long QT syndrome 2 short QT syndrome type 1 muscular atrophy atrial fibrillation torsades de pointes malignant colon neoplasm Brugada syndrome short QT syndrome cancer familial atrial fibrillation schizophrenia subependymal giant cell astrocytoma hypertensive disorder ventricular fibrillation adrenal cortex carcinoma LONG QT SYNDROME 2/5, DIGENIC (disorder) arrhythmogenic right ventricular cardiomyopathy autosomal dominant cardiac arrhythmia (Kuhn) medulloblastoma cardiomyopathy carpal tunnel syndrome osteosarcoma colonic neoplasm psoriasis familial long QT syndrome Lambert-Eaton myasthenic syndrome long QT syndrome 1 allergic rhinitis malignant ependymoma benign colon neoplasm metabolic syndrome X myocardial infarction ovarian cancer dilated cardiomyopathy heart disease lung carcinoma atypical teratoid rhabdoid tumor malignant mesothelioma benign neoplasm multiple sclerosis cerebrovascular disorder

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Peptides	Alpha-helical peptides	Peptides of transmembrane proteins	Voltage-gated channel peptides

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.