1UUN | pdb_00001uun

Main porin from Mycobacterium smegmatis (MspA)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uuna_	Membrane and cell surface proteins and peptides	Leukocidin-like	Leukocidin-like	Porin MspA	Porin MspA	(Mycolicibacterium smegmatis ) [TaxId: 1772 ],	SCOPe (2.08)
B	d1uunb_	Membrane and cell surface proteins and peptides	Leukocidin-like	Leukocidin-like	Porin MspA	Porin MspA	(Mycolicibacterium smegmatis ) [TaxId: 1772 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Porin MspA	8022753	4001774	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Leukocidin-like	8035133	3000256	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Leukocidin-like	8035133	3000256	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MspA	e1uunA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Leukocidin-like (From Topology)	T: Leukocidin-like	F: MspA	ECOD (1.6)
B	MspA	e1uunB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Leukocidin-like (From Topology)	T: Leukocidin-like	F: MspA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.1650	Mainly Beta	Sandwich	Immunoglobulin-like	Porin MspA (Ig-like beta-sandwich domain)	CATH (4.3.0)
A	2.10.300.10	Mainly Beta	Ribbon	Porin MspA ribbon fold	Porin MspA ribbon domain	CATH (4.3.0)
B	2.60.40.1650	Mainly Beta	Sandwich	Immunoglobulin-like	Porin MspA (Ig-like beta-sandwich domain)	CATH (4.3.0)
B	2.10.300.10	Mainly Beta	Ribbon	Porin MspA ribbon fold	Porin MspA ribbon domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09203	MspA (MspA)	MspA	MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each ...	MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	MSPA	wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity	localization transport iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport	cellular anatomical structure extracellular region protein-containing complex membrane pore complex membrane protein complex cell periphery cell outer membrane external encapsulating structure cell envelope outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036435	Leukocidin/porin MspA superfamily	Homologous Superfamily
A, B	IPR015286	Porin family, mycobacterial-type	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Beta-barrel transmembrane	Mycobacterial Porin (MBP) (n=16,S=16)	Mycobacterial Porin (MBP) (n=16,S=16)

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: BETA-BARREL	Beta-Barrel Membrane Proteins: Porins and Relatives	MspA mycobacterial porin

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.