1WOU | pdb_00001wou

Crystal Structure of human Trp14

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1woua_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Txnl5-like	Putative 42-9-9 protein (thioredoxin containing protein Txnl5)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Txnl5-like	8029413	4002204	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8041792	3000031	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF953	e1wouA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: DUF953	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF06110	Thioredoxin domain-containing protein 17-like, thioredoxin domain (TXD17-like_Trx)	Thioredoxin domain-containing protein 17-like, thioredoxin domain	This is the thioredoxin domain from in Thioredoxin domain-containing protein 17, also known as TRP14, which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways [1]. This domain ...	This is the thioredoxin domain from in Thioredoxin domain-containing protein 17, also known as TRP14, which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways [1]. This domain is also found at the C-terminal of Acireductone dioxygenase (ARD) from Leishmania.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	thioredoxin -related protein, 14 kDa	protein-disulfide reductase [NAD(P)H] activity oxidoreductase activity, acting on a sulfur group of donors oxidoreductase activity disulfide oxidoreductase activity catalytic activity, acting on a protein protein-disulfide reductase activity catalytic activity oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor peroxidase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular process cellular response to cytokine stimulus signal transduction response to tumor necrosis factor	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010357	Thioredoxin domain-containing protein 17-like domain	Domain
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A	IPR045108	Thioredoxin domain-containing protein 17-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BRA2	esophageal squamous cell carcinoma breast carcinoma invasive ductal breast carcinoma ovarian cancer lung adenocarcinoma psoriasis glioblastoma non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.