1ZCZ | pdb_00001zcz

Crystal structure of Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase (TM1249) from THERMOTOGA MARITIMA at 1.88 A resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zcza1	Alpha and beta proteins (a/b)	Methylglyoxal synthase-like	Methylglyoxal synthase-like	Inosicase	IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
A	d1zcza2	Alpha and beta proteins (a/b)	Cytidine deaminase-like	Cytidine deaminase-like	AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC	AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
B	d1zczb1	Alpha and beta proteins (a/b)	Methylglyoxal synthase-like	Methylglyoxal synthase-like	Inosicase	IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
B	d1zczb2	Alpha and beta proteins (a/b)	Cytidine deaminase-like	Cytidine deaminase-like	AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC	AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
B	d1zczb3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Inosicase	8023221	4003369	SCOP2 (2022-06-29)
A	SCOP2 Family	AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC	8023223	4003464	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Methylglyoxal synthase-like	8035601	3001443	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cytidine deaminase-like	8035603	3001838	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cytidine deaminase-like	8035603	3001838	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Methylglyoxal synthase-like	8035601	3001443	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AICARFT_IMPCHas_1st	e1zczA3	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: AICARFT_IMPCHas_1st	ECOD (1.6)
A	AICARFT_IMPCHas_2nd	e1zczA4	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: AICARFT_IMPCHas_2nd	ECOD (1.6)
A	MGS	e1zczA1	A: a/b three-layered sandwiches	X: Methylglyoxal synthase-like (From Topology)	H: Methylglyoxal synthase-like (From Topology)	T: Methylglyoxal synthase-like	F: MGS	ECOD (1.6)
B	AICARFT_IMPCHas_1st	e1zczB4	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: AICARFT_IMPCHas_1st	ECOD (1.6)
B	AICARFT_IMPCHas_2nd	e1zczB3	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: AICARFT_IMPCHas_2nd	ECOD (1.6)
B	MGS	e1zczB5	A: a/b three-layered sandwiches	X: Methylglyoxal synthase-like (From Topology)	H: Methylglyoxal synthase-like (From Topology)	T: Methylglyoxal synthase-like	F: MGS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1380	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylglyoxal synthase-like domain	CATH (4.3.0)
A	3.40.140.20	Alpha Beta	3-Layer(aba) Sandwich	Cytidine Deaminase	domain 2	CATH (4.3.0)
B	3.40.50.1380	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylglyoxal synthase-like domain	CATH (4.3.0)
B	3.40.140.20	Alpha Beta	3-Layer(aba) Sandwich	Cytidine Deaminase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02142	MGS-like domain (MGS)	MGS-like domain	This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the allosteric effector ornithine. This family also includes ino ...	This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the allosteric effector ornithine. This family also includes inosicase. The known structures in this family show a common phosphate binding site [1].	Domain
A, B	PF01808	AICARFT/IMPCHase bienzyme (AICARFT_IMPCHas)	AICARFT/IMPCHase bienzyme	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Bifunctional purine biosynthesis protein purH	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IMP cyclohydrolase activity cyclohydrolase activity hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds phosphoribosylaminoimidazolecarboxamide formyltransferase activity transferase activity, transferring one-carbon groups transferase activity hydroxymethyl-, formyl- and related transferase activity	ribose phosphate metabolic process IMP metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process ribose phosphate metabolic process IMP metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside monophosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process purine-containing compound metabolic process IMP biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process 'de novo' IMP biosynthetic process purine ribonucleotide metabolic process ribonucleoside monophosphate biosynthetic process purine nucleotide biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR024051	AICAR transformylase, duplicated domain superfamily	Homologous Superfamily
A, B	IPR011607	Methylglyoxal synthase-like domain	Domain
A, B	IPR036914	Methylglyoxal synthase-like domain superfamily	Homologous Superfamily
A, B	IPR002695	Bifunctional purine biosynthesis protein PurH-like	Family
A, B	IPR016193	Cytidine deaminase-like	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.