2A98 | pdb_00002a98

Crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2a98a_	Alpha and beta proteins (a+b)	SAICAR synthase-like	SAICAR synthase-like	Inositol polyphosphate kinase (IPK)	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Inositol polyphosphate kinase (IPK)	8077884	4002804	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SAICAR synthase-like	8077885	3000802	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IPK	e2a98A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: SAICAR synthase	F: IPK	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.470.160	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03770	Inositol polyphosphate kinase (IPK)	Inositol polyphosphate kinase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Inositol 1,4,5-trisphosphate 3-kinase C	kinase activity transferase activity inositol-1,4,5-trisphosphate 3-kinase activity inositol phosphate kinase activity inositol trisphosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding kinase activity transferase activity inositol-1,4,5-trisphosphate 3-kinase activity inositol phosphate kinase activity inositol trisphosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding inositol hexakisphosphate kinase activity phosphotransferase activity, phosphate group as acceptor protein binding calmodulin binding	polyol metabolic process small molecule biosynthetic process alcohol metabolic process inositol phosphate metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process inositol phosphate biosynthetic process phosphate-containing compound metabolic process polyol biosynthetic process alcohol biosynthetic process metabolic process cellular process small molecule metabolic process polyol metabolic process small molecule biosynthetic process alcohol metabolic process inositol phosphate metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process inositol phosphate biosynthetic process phosphate-containing compound metabolic process polyol biosynthetic process alcohol biosynthetic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process glycerolipid biosynthetic process glycerolipid metabolic process lipid metabolic process cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck ribonucleoprotein granule intracellular organelle nuclear body cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck ribonucleoprotein granule intracellular organelle nuclear body cellular anatomical structure nucleoplasm organelle lumen organelle membraneless organelle supramolecular complex nuclear ribonucleoprotein granule nuclear lumen cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038286	Inositol polyphosphate kinase superfamily	Homologous Superfamily
A	IPR005522	Inositol polyphosphate kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96DU7	mucocutaneous lymph node syndrome coronary aneurysm lung carcinoma atypical teratoid rhabdoid tumor glioblastoma psoriasis chronic obstructive pulmonary disease lung cancer ovarian cancer Sjogren syndrome pilocytic astrocytoma spina bifida

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.