2CZV | pdb_00002czv

Crystal structure of archeal RNase P protein ph1481p in complex with ph1877p

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d2czvd_	Alpha and beta proteins (a+b)	Ferredoxin-like	Rnp2-like	Rpp14/Pop5-like	RNase P protein component 2, Rnp2	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
C	d2czvc1	Alpha and beta proteins (a+b)	Ferredoxin-like	Rnp2-like	Rpp14/Pop5-like	RNase P protein component 2, Rnp2	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
B	d2czvb_	Alpha and beta proteins (a/b)	7-stranded beta/alpha barrel	PHP domain-like	RNase P subunit p30	Ribonuclease P protein component 3, Rnp3	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
A	d2czva_	Alpha and beta proteins (a/b)	7-stranded beta/alpha barrel	PHP domain-like	RNase P subunit p30	Ribonuclease P protein component 3, Rnp3	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Rnp2-like	8032786	3000630	SCOP2B (2022-06-29)
C	SCOP2 Family	Rpp14/Pop5-like	8020406	4001975	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Rnp2-like	8032786	3000630	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	PHP domain-like	8041184	3000312	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PHP domain-like	8041184	3000312	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	RNase_P_Rpp14	e2czvD1	A: a+b two layers	X: Alpha-beta plaits	H: Rpp14/Pop5-like (From Topology)	T: Rpp14/Pop5-like	F: RNase_P_Rpp14	ECOD (1.6)
C	RNase_P_Rpp14	e2czvC1	A: a+b two layers	X: Alpha-beta plaits	H: Rpp14/Pop5-like (From Topology)	T: Rpp14/Pop5-like	F: RNase_P_Rpp14	ECOD (1.6)
B	RNase_P_p30	e2czvB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: RNase_P_p30	ECOD (1.6)
A	RNase_P_p30	e2czvA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: RNase_P_p30	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.30.70.3250	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Ribonuclease P, Pop5 subunit	CATH (4.3.0)
C	3.30.70.3250	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Ribonuclease P, Pop5 subunit	CATH (4.3.0)
B	3.20.20.140	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Metal-dependent hydrolases	CATH (4.3.0)
A	3.20.20.140	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Metal-dependent hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, D	PF01900	Rpp14/Pop5 family (RNase_P_Rpp14)	Rpp14/Pop5 family	-	Family
A, B	PF01876	RNase P subunit p30 (RNase_P_p30)	RNase P subunit p30	This protein is part of the RNase P complex that is involved in tRNA maturation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D	Ribonuclease P protein component 2	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity catalytic activity, acting on a tRNA hydrolase activity nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity catalytic activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process tRNA processing RNA 5'-end processing metabolic process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process tRNA processing RNA 5'-end processing metabolic process cellular process macromolecule metabolic process RNA processing tRNA 5'-leader removal tRNA 5'-end processing	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex endoribonuclease complex catalytic complex ribonuclease P complex ribonucleoprotein complex intracellular protein-containing complex endonuclease complex
A, B	Ribonuclease P protein component 3	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity catalytic activity, acting on a tRNA hydrolase activity nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity catalytic activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process tRNA processing RNA 5'-end processing metabolic process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process tRNA processing RNA 5'-end processing metabolic process cellular process macromolecule metabolic process RNA processing tRNA 5'-leader removal tRNA 5'-end processing	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex endoribonuclease complex catalytic complex ribonuclease P complex ribonucleoprotein complex intracellular protein-containing complex endonuclease complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D	IPR002759	RNase P subunit Pop5/Rpp14/Rnp2-like	Family
C, D	IPR016434	Rnp2_archaea	Unknown
C, D	IPR038085	RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily	Homologous Superfamily
A, B	IPR016195	Polymerase/histidinol phosphatase-like	Homologous Superfamily
A, B	IPR023539	Ribonuclease P, protein component 3, archaeal	Family
A, B	IPR002738	RNase P subunit p30	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.