2E3V | pdb_00002e3v

Crystal structure of the first fibronectin type III domain of neural cell adhesion molecule splicing isoform from human muscle culture lambda-4.4

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2e3va1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Neural cell adhesion molecule 1, NCAM	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2e3va2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2e3vb1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Neural cell adhesion molecule 1, NCAM	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2e3vb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2e3vc1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Neural cell adhesion molecule 1, NCAM	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2e3vc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Fibronectin type III	8055119	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055119	3002063	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibronectin type III	8055119	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	fn3	e2e3vA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
B	fn3	e2e3vB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
C	fn3	e2e3vC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Neural cell adhesion molecule 1, 140 kDa isoform	protein binding binding virus receptor activity exogenous protein binding	developmental process cellular developmental process cell differentiation animal organ development anatomical structure development mesenchyme development cellular process mesenchymal cell differentiation tissue development epithelial to mesenchymal transition cell adhesion commissural neuron axon guidance multicellular organismal process axonogenesis developmental process cellular developmental process cell differentiation animal organ development anatomical structure development mesenchyme development cellular process mesenchymal cell differentiation tissue development epithelial to mesenchymal transition cell adhesion commissural neuron axon guidance multicellular organismal process axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cellular component organization or biogenesis system development plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling semaphorin-plexin signaling pathway biological regulation regulation of signal transduction cell communication regulation of semaphorin-plexin signaling pathway regulation of response to stimulus regulation of cell communication signal transduction	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular region membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus intracellular membrane-bounded organelle endomembrane system cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular region membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus intracellular membrane-bounded organelle endomembrane system intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C	IPR003598	Immunoglobulin subtype 2	Domain
A, B, C	IPR003961	Fibronectin type III	Domain
A, B, C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C	IPR009138	Neural cell adhesion	Family
A, B, C	IPR003599	Immunoglobulin domain subtype	Domain
A, B, C	IPR007110	Immunoglobulin-like domain	Domain
A, B, C	IPR013098	Immunoglobulin I-set	Domain
A, B, C	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P13591	Neoplasm Invasiveness invasive ductal breast carcinoma lung carcinoma major depressive disorder malignant glioma medulloblastoma astrocytic tumor pancreatic intraductal papillary-mucinous neoplasm autoimmune disease pituitary cancer breast cancer schizophrenia depressive disorder tuberculosis endogenous depression Neoplasm Invasiveness invasive ductal breast carcinoma lung carcinoma major depressive disorder malignant glioma medulloblastoma astrocytic tumor pancreatic intraductal papillary-mucinous neoplasm autoimmune disease pituitary cancer breast cancer schizophrenia depressive disorder tuberculosis endogenous depression glioblastoma large cell medulloblastoma lung disease malignant colon neoplasm malignant mesothelioma oligodendroglioma attention deficit hyperactivity disorder, inattentive type pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia bipolar disorder primitive neuroectodermal tumor cancer Down syndrome type 1 diabetes mellitus gastric cancer interstitial lung disease lung cancer lymphatic system disease malignant ependymoma osteosarcoma atypical teratoid rhabdoid tumor pilocytic astrocytoma bone marrow disease psoriasis subependymal giant cell astrocytoma ductal breast carcinoma in situ gastric carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.