2EQM | pdb_00002eqm

Solution structure of the TUDOR domain of PHD finger protein 20-like 1 [Homo sapiens]

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MBT_1	e2eqmA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: MBT_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.140	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PHD finger protein 20-like 1	protein binding binding modification-dependent protein binding methylation-dependent protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	catabolic process regulation of cellular process negative regulation of biological process macromolecule catabolic process negative regulation of protein catabolic process regulation of primary metabolic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process catabolic process regulation of cellular process negative regulation of biological process macromolecule catabolic process negative regulation of protein catabolic process regulation of primary metabolic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of ubiquitin-dependent protein catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process proteasomal protein catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen NSL complex protein-containing complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen NSL complex protein-containing complex catalytic complex intracellular membraneless organelle chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex membraneless organelle protein acetyltransferase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR047405	PHD finger protein 20-like protein 1, Tudor domain	Domain
A	IPR002999	Tudor domain	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR014002	Agenet domain, plant type	Domain
A	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A	IPR040477	Lysine-specific demethylase 4-like, Tudor domain	Domain
A	IPR043449	PHD finger protein 20-like	Family
A	IPR019786	Zinc finger, PHD-type, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: A8MW92	psoriasis tuberculosis attention deficit hyperactivity disorder, inattentive type glioblastoma hyperthyroidism malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm progressive supranuclear palsy rheumatoid arthritis vitiligo atypical teratoid rhabdoid tumor Hashimoto thyroiditis hypothyroidism malignant pancreatic neoplasm psoriasis tuberculosis attention deficit hyperactivity disorder, inattentive type glioblastoma hyperthyroidism malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm progressive supranuclear palsy rheumatoid arthritis vitiligo atypical teratoid rhabdoid tumor Hashimoto thyroiditis hypothyroidism malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia prostate carcinoma subependymal giant cell astrocytoma exocrine pancreatic carcinoma hepatocellular carcinoma large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma Pick disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.