2I27

Crystal Structure Analysis of the Nurse Shark New Antigen Receptor Ancestral variable domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth N]	d2i27n2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	nurse shark (Ginglymostoma cirratum ) [TaxId: 7801 ],	SCOPe (2.08)
A [auth N]	d2i27n3	Artifacts	Tags	Tags	Tags	C-terminal Tags	nurse shark (Ginglymostoma cirratum ) [TaxId: 7801 ],	SCOPe (2.08)
B [auth O]	d2i27o2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	nurse shark (Ginglymostoma cirratum ) [TaxId: 7801 ],	SCOPe (2.08)
B [auth O]	d2i27o3	Artifacts	Tags	Tags	Tags	C-terminal Tags	nurse shark (Ginglymostoma cirratum ) [TaxId: 7801 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth N]	SCOP2 Family	V set domains-like	8054520	4007530	SCOP2 (2022-06-29)
A [auth N]	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8054521	3000071	SCOP2 (2022-06-29)
B [auth O]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054521	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth N]	Beta-APP	e2i27N1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Beta-APP	ECOD (1.6)
B [auth O]	Beta-APP	e2i27O1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Beta-APP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth N]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B [auth O]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth N], B [auth O]	IGHN (IgNAR)	VH	Ginglymostoma cirratum (nurse shark)	IGHV2S1301, IGHJ101	V-DOMAIN VH	IG	(VH)	IMGT (202452-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth N], B [auth O]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth N], B [auth O]	New Antigen Receptor Ancestral	binding antigen binding peptide antigen binding peptide binding	-	cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex T cell receptor complex receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth N], B [auth O]	IPR051006	T cell receptor variable domain	Family
A [auth N], B [auth O]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth N], B [auth O]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth N], B [auth O]	IPR013106	Immunoglobulin V-set domain	Domain
A [auth N], B [auth O]	IPR003599	Immunoglobulin domain subtype	Domain
A [auth N], B [auth O]	IPR007110	Immunoglobulin-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.