2I88 | pdb_00002i88

Crystal structure of the Channel-forming Domain of Colicin E1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Colicin	8085469	4002963	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Colicin	8085470	3001946	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Colicin	e2i88A1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Colicin (From Topology)	T: Colicin	F: Colicin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.490.30	Mainly Alpha	Orthogonal Bundle	Globin-like	Colicin	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Colicin-E1	protein binding binding transmembrane transporter binding pore-forming activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium response to bacterium response to stress response to external biotic stimulus regulation of localization negative regulation of ion transmembrane transporter activity regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium response to bacterium response to stress response to external biotic stimulus regulation of localization negative regulation of ion transmembrane transporter activity regulation of cellular process transport negative regulation of monoatomic ion transport monoatomic ion transmembrane transport negative regulation of biological process regulation of transmembrane transporter activity negative regulation of transport regulation of monoatomic ion transmembrane transport negative regulation of transmembrane transport localization negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport regulation of biological process regulation of transport regulation of monoatomic ion transport negative regulation of transporter activity biological regulation negative regulation of molecular function establishment of localization transmembrane transport regulation of molecular function regulation of transmembrane transport cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038283	Channel forming colicin, C-terminal domain superfamily	Homologous Superfamily
A	IPR000293	Channel forming colicin, C-terminal cytotoxic	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Monotopic/peripheral	All alpha monotopic/peripheral	Colicin pore forming domain	Colicin pore forming domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.