2IFA

Crystal Structure of the PUTATIVE NITROREDUCTASE (SMU.260) IN COMPLEX WITH FMN FROM STREPTOCOCCUS MUTANS, NORTHEAST STRUCTURAL GENOMICS TARGET SMR5.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ifaa1	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	Hypothetical protein Smu.260	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
A	d2ifaa2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
B	d2ifab2	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	Hypothetical protein Smu.260	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
B	d2ifab3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
C	d2ifac2	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	Hypothetical protein Smu.260	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
C	d2ifac3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
D	d2ifad2	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	Hypothetical protein Smu.260	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
D	d2ifad3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
E	d2ifae2	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	Hypothetical protein Smu.260	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
E	d2ifae3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)
F	d2ifaf_	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	Hypothetical protein Smu.260	(Streptococcus mutans UA159 ) [TaxId: 210007 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NADH oxidase/flavin reductase	8030336	4001599	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	FMN-dependent nitroreductase-like	8042715	3001947	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8042715	3001947	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8042715	3001947	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8042715	3001947	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8042715	3001947	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8042715	3001947	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Nitroreductase	e2ifaA1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
B	Nitroreductase	e2ifaB1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
C	Nitroreductase	e2ifaC1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
D	Nitroreductase	e2ifaD1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
E	Nitroreductase	e2ifaE1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
F	Nitroreductase	e2ifaF1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
B	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
C	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
D	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
E	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
F	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00881	Nitroreductase family (Nitroreductase)	Nitroreductase family	The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Hypothetical protein SMU.260	oxidoreductase activity catalytic activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	cellular response to stimulus response to oxidative stress cellular response to chemical stimulus response to stimulus cellular response to stress response to stress response to chemical cellular response to oxidative stress cellular process cellular response to chemical stress	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR029479	Nitroreductase	Domain
A, B, C, D, E A, B, C, D, E, F	IPR000415	Nitroreductase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR033877	Nitroreductase Frm2/Hbn1-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.