2JWG | pdb_00002jwg

Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	VSG C-terminal domain-like	8090316	4004431	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	VSG C-terminal domain-like	8090317	3002428	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trypan_glycop_C_like_1	e2jwgA1	A: few secondary structure elements	X: Variant surface glycoprotein MITAT 1.2, VSG 221, C-terminal domain (From Topology)	H: Variant surface glycoprotein MITAT 1.2, VSG 221, C-terminal domain (From Topology)	T: Variant surface glycoprotein MITAT 1.2, VSG 221, C-terminal domain	F: Trypan_glycop_C_like_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1680.30	Alpha Beta	2-Layer Sandwich	ligand-binding face of the semaphorins, domain 2		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10659	Trypanosome variant surface glycoprotein C-terminal domain (Trypan_glycop_C)	Trypanosome variant surface glycoprotein C-terminal domain	The trypanosome parasite expresses these proteins to evade the immune response.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Variant surface glycoprotein ILTAT 1.24	-	symbiont-mediated perturbation of host defense response biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated response to host defenses response to external stimulus biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated perturbation of host process response to host immune response symbiont-mediated evasion of host immune response response to host symbiont-mediated perturbation of host defense response biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated response to host defenses response to external stimulus biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated perturbation of host process response to host immune response symbiont-mediated evasion of host immune response response to host response to external biotic stimulus modulation of process of another organism	cellular anatomical structure membrane side of membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019609	Trypanosome variant surface glycoprotein, C-terminal	Domain
A	IPR001812	Trypanosome variant surface glycoprotein, A-type, N-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.