Annotations: 2K2W

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NIBRIN-like	8045682	4004613	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	BRCT domain-like	8091435	3000159	SCOP2 (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10980	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Nibrin, BRCT2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16508	Second BRCT domain on Nijmegen syndrome breakage protein (NIBRIN_BRCT_II)	Second BRCT domain on Nijmegen syndrome breakage protein		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Recombination and DNA repair protein	chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding binding damaged DNA binding nucleic acid binding transcription factor binding protein binding DNA-binding transcription factor binding enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding binding damaged DNA binding nucleic acid binding transcription factor binding protein binding DNA-binding transcription factor binding enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity phosphorylation-dependent protein binding modification-dependent protein binding	cellular response to stimulus telomere maintenance in response to DNA damage response to stimulus telomere organization chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organelle organization cellular response to stress DNA damage response response to stress cellular response to stimulus telomere maintenance in response to DNA damage response to stimulus telomere organization chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organelle organization cellular response to stress DNA damage response response to stress cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process double-strand break repair DNA double-strand break processing DNA repair chromatin organization chromatin remodeling R-loop processing localization protein localization to chromosome protein localization to organelle macromolecule localization protein localization to site of double-strand break intracellular protein localization regulation of biological process fibroblast proliferation cell population proliferation regulation of cellular process regulation of cell population proliferation biological regulation regulation of fibroblast proliferation DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity DNA replication DNA strand resection involved in replication fork processing replication fork processing regulation of cell cycle phase transition DNA damage checkpoint signaling signaling G2/M transition of mitotic cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cell communication regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition signal transduction in response to DNA damage negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition DNA recombination recombinational repair double-strand break repair via homologous recombination protection from non-homologous end joining at telomere telomere capping immune system development adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process lymphocyte mediated immunity immunoglobulin production immunoglobulin production involved in immunoglobulin-mediated immune response somatic cell DNA recombination B cell activation involved in immune response lymphocyte activation cell activation involved in immune response leukocyte activation multicellular organism development somatic diversification of immunoglobulins involved in immune response somatic recombination of immunoglobulin gene segments leukocyte activation involved in immune response anatomical structure development leukocyte mediated immunity somatic diversification of immune receptors lymphocyte activation involved in immune response somatic recombination of immunoglobulin genes involved in immune response system development developmental process production of molecular mediator of immune response immune response B cell activation cell activation gene expression macromolecule biosynthetic process immunoglobulin mediated immune response adaptive immune response immune effector process somatic diversification of immunoglobulins biosynthetic process immune system process somatic diversification of immune receptors via germline recombination within a single locus B cell mediated immunity isotype switching metaphase chromosome alignment chromosome localization organelle localization nuclear chromosome segregation chromosome segregation sexual reproduction reproductive process meiotic cell cycle	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure Mre11 complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle inclusion body nuclear inclusion body site of double-strand break membraneless organelle membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure Mre11 complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle inclusion body nuclear inclusion body site of double-strand break membraneless organelle site of DNA damage intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen PML body nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032429	Nibrin, second BRCT domain	Domain
A	IPR040227	Nibrin-related	Family
A	IPR001357	BRCT domain	Domain
A	IPR013908	Nibrin, C-terminal	Domain
A	IPR043014	Nibrin, second BRCT domain superfamily	Homologous Superfamily
A	IPR036420	BRCT domain superfamily	Homologous Superfamily
A	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A	IPR000253	Forkhead-associated (FHA) domain	Domain
A	IPR016592	Nibrin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.