2KSO | pdb_00002kso

EphA2:SHIP2 SAM:SAM complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ksoa_	All alpha proteins	SAM domain-like	SAM/Pointed domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2ksob_	All alpha proteins	SAM domain-like	SAM/Pointed domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SAM/Pointed domain	8079647	3000479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SAM_1	e2ksoA1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_1	ECOD (1.6)
B	SAM_1	e2ksoB1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00536	SAM domain (Sterile alpha motif) (SAM_1)	SAM domain (Sterile alpha motif)	It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module ...	It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.	Domain
B	PF00536	SAM domain (Sterile alpha motif) (SAM_1)	SAM domain (Sterile alpha motif)	It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module ...	It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ephrin type-A receptor 2	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity GPI-linked ephrin receptor activity protein-hormone receptor activity insulin receptor activity histone H3Y41 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity placental growth factor receptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity cell adhesion molecule binding cadherin binding protein binding brain-derived neurotrophic factor receptor activity neurotrophin receptor activity insulin-like growth factor receptor activity hepatocyte growth factor receptor activity virus receptor activity exogenous protein binding boss receptor activity epidermal growth factor receptor activity macrophage colony-stimulating factor receptor activity platelet-derived growth factor alpha-receptor activity growth factor binding fibroblast growth factor receptor activity molecular function activator activity molecular function regulator activity vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone H2AX kinase activity	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis regulation of angiogenesis anatomical structure formation involved in morphogenesis anatomical structure development regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development skeletal system development positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization cellular process regulation of protein localization to plasma membrane cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway cell migration cell motility cellular developmental process animal organ development cell development notochord cell development embryo development cell differentiation embryonic organ development notochord development notochord cell differentiation negative regulation of biological process negative regulation of chemokine production regulation of cytokine production cytokine production negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of chemokine production regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process chemokine production regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process post-anal tail morphogenesis lymphangiogenesis negative regulation of developmental process regulation of lymphangiogenesis negative regulation of lymphangiogenesis lymph vessel morphogenesis lymph vessel development regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration regulation of locomotion regulation of cell migration regulation of endothelial cell migration blood vessel endothelial cell migration locomotion cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical sensory organ development visual system development cell morphogenesis epithelial cell differentiation eye morphogenesis lens morphogenesis in camera-type eye animal organ morphogenesis sensory system development camera-type eye morphogenesis lens fiber cell morphogenesis epithelium development eye development tissue development lens fiber cell development epithelial cell development sensory organ morphogenesis camera-type eye development lens fiber cell differentiation lens development in camera-type eye regulation of signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cell adhesion cell population proliferation blood vessel endothelial cell proliferation involved in sprouting angiogenesis endothelial cell proliferation sprouting angiogenesis epithelial cell proliferation branching involved in mammary gland duct morphogenesis mammary gland morphogenesis mammary gland development branching morphogenesis of an epithelial tube gland development gland morphogenesis epithelial tube morphogenesis morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis mammary gland epithelium development morphogenesis of a branching structure morphogenesis of a branching epithelium nucleoside phosphate metabolic process ribose phosphate metabolic process cAMP metabolic process cyclic purine nucleotide metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process cyclic nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process purine ribonucleotide metabolic process phosphorus metabolic process tissue remodeling bone remodeling embryonic organ morphogenesis embryonic morphogenesis notochord morphogenesis notochord formation nervous system development ossification osteoblast differentiation epidermal cell differentiation epidermis development skin development keratinocyte differentiation cell adhesion mediated by integrin regulation of cell adhesion mediated by integrin regulation of cell adhesion pericyte cell differentiation formation of primary germ layer mesoderm morphogenesis gastrulation axial mesoderm development axial mesoderm formation axial mesoderm morphogenesis mesoderm formation mesoderm development generation of neurons neurogenesis neuron differentiation mammary gland epithelial cell proliferation cell death apoptotic signaling pathway cellular response to stress DNA damage response response to stress intrinsic apoptotic signaling pathway in response to DNA damage apoptotic process intrinsic apoptotic signaling pathway programmed cell death vasculogenesis positive regulation of locomotion positive regulation of cell migration positive regulation of cell motility response to endogenous stimulus response to growth factor myeloid leukocyte differentiation hemopoiesis myeloid cell differentiation osteoclast differentiation leukocyte differentiation activation of GTPase activity positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity defense response inflammatory response neural tube development chordate embryonic development embryo development ending in birth or egg hatching lamellipodium assembly regulation of cellular component organization plasma membrane bounded cell projection organization cell projection organization regulation of cell projection organization regulation of cell projection assembly plasma membrane bounded cell projection assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of plasma membrane bounded cell projection assembly regulation of lamellipodium assembly cellular component assembly regulation of lamellipodium organization lamellipodium organization cellular component organization or biogenesis regulation of plasma membrane bounded cell projection organization cell projection assembly negative regulation of blood vessel morphogenesis negative regulation of angiogenesis negative regulation of vasculature development bicellular tight junction assembly positive regulation of cellular component organization tight junction organization cell junction assembly cell-cell junction assembly cell-cell junction organization regulation of bicellular tight junction assembly positive regulation of cellular component biogenesis apical junction assembly regulation of cell junction assembly positive regulation of cell junction assembly positive regulation of bicellular tight junction assembly cell junction organization tight junction assembly biological process involved in interspecies interaction between organisms response to other organism defense response to Gram-positive bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium protein-containing complex receptor complex anchoring junction cell junction focal adhesion cell-substrate junction ruffle plasma membrane membrane cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium protein-containing complex receptor complex anchoring junction cell junction focal adhesion cell-substrate junction ruffle plasma membrane membrane leading edge membrane cell periphery ruffle membrane plasma membrane region cell projection membrane cell surface lamellipodium membrane cell-cell junction tight junction
B	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	inositol trisphosphate phosphatase activity phosphoric ester hydrolase activity inositol-polyphosphate 5-phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein binding binding SH2 domain binding protein domain specific binding SH3 domain binding phosphatidylinositol trisphosphate phosphatase activity inositol trisphosphate phosphatase activity phosphoric ester hydrolase activity inositol-polyphosphate 5-phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein binding binding SH2 domain binding protein domain specific binding SH3 domain binding phosphatidylinositol trisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity phosphatidylinositol phosphate phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity cytoskeletal protein binding actin binding	phosphatidylinositol metabolic process dephosphorylation glycerophospholipid metabolic process lipid modification primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphatidylinositol dephosphorylation phospholipid dephosphorylation phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process phosphatidylinositol metabolic process dephosphorylation glycerophospholipid metabolic process lipid modification primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphatidylinositol dephosphorylation phospholipid dephosphorylation phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication intracellular signaling cassette signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction localization import into cell transport endocytosis establishment of localization vesicle-mediated transport MAPK cascade ERK1 and ERK2 cascade apoptotic process cell death programmed cell death developmental process endochondral ossification multicellular organismal process replacement ossification animal organ development endochondral bone morphogenesis multicellular organism development anatomical structure morphogenesis skeletal system development ossification anatomical structure development skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development system development regulation of response to stimulus immune response immune system process regulation of immune response regulation of immune system process regulation of cytoskeleton organization regulation of actin filament organization regulation of cellular component organization regulation of actin filament-based process actin cytoskeleton organization actin filament organization regulation of organelle organization cellular component organization organelle organization regulation of actin cytoskeleton organization actin filament-based process regulation of supramolecular fiber organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization glycerophospholipid biosynthetic process lipid biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate biosynthetic process monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process glucose metabolic process establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of cell polarity mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process macromolecule metabolic process gene expression macromolecule biosynthetic process plasma membrane bounded cell projection organization ruffle organization cell projection organization plasma membrane bounded cell projection assembly ruffle assembly cellular component biogenesis cellular component assembly cell projection assembly negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process protein localization regulation of localization regulation of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to insulin response to oxygen-containing compound response to nitrogen compound cell adhesion negative regulation of signaling regulation of signal transduction negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway regulation of insulin-like growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus insulin-like growth factor receptor signaling pathway negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of signal transduction regulation of cell communication regulation of biosynthetic process negative regulation of metabolic process regulation of macromolecule metabolic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of macromolecule metabolic process post-embryonic development	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region cytoplasm cytosol Golgi apparatus endomembrane system actin-based cell projection filopodium

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site	Conserved Site
A	IPR008266	Tyrosine-protein kinase, active site	Active Site
A	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A	IPR000719	Protein kinase domain	Domain
A	IPR016257	Ephrin receptor type-A /type-B	Family
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR001660	Sterile alpha motif domain	Domain
A	IPR001090	Ephrin receptor ligand binding domain	Domain
A	IPR034263	Ephrin type-A receptor 2, ligand binding domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A	IPR027936	Ephrin receptor, transmembrane domain	Domain
A	IPR050449	Ephrin receptor tyrosine kinases	Family
A	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A	IPR003961	Fibronectin type III	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
B	IPR036860	SH2 domain superfamily	Homologous Superfamily
B	IPR000980	SH2 domain	Domain
B	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
B	IPR000300	Inositol polyphosphate-related phosphatase	Domain
B	IPR036691	Endonuclease/exonuclease/phosphatase superfamily	Homologous Superfamily
B	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P29317	Noonan syndrome cancer Noonan syndrome with multiple lentigines cataract 6 multiple types cataract nasopharyngeal carcinoma Nuclear non-senile cataract pancreatic intraductal papillary-mucinous neoplasm adrenal cortex carcinoma sarcoidosis benign neoplasm squamous cell lung carcinoma malignant pancreatic neoplasm ovarian cancer atopic eczema Noonan syndrome cancer Noonan syndrome with multiple lentigines cataract 6 multiple types cataract nasopharyngeal carcinoma Nuclear non-senile cataract pancreatic intraductal papillary-mucinous neoplasm adrenal cortex carcinoma sarcoidosis benign neoplasm squamous cell lung carcinoma malignant pancreatic neoplasm ovarian cancer atopic eczema sinusitis gastric adenocarcinoma medulloblastoma non-alcoholic fatty liver disease nuclear cataract pancreatic ductal adenocarcinoma psoriasis atypical teratoid rhabdoid tumor spina bifida breast cancer ulcerative colitis lung carcinoma
B	Pharos: O15357	opsismodysplasia metabolic syndrome X type 2 diabetes mellitus schneckenbecken dysplasia hypertensive disorder Liver Cirrhosis, Experimental acquired metabolic disease intellectual disability lung carcinoma ovarian cancer astrocytic tumor glioblastoma large cell medulloblastoma malignant ependymoma diabetes mellitus opsismodysplasia metabolic syndrome X type 2 diabetes mellitus schneckenbecken dysplasia hypertensive disorder Liver Cirrhosis, Experimental acquired metabolic disease intellectual disability lung carcinoma ovarian cancer astrocytic tumor glioblastoma large cell medulloblastoma malignant ependymoma diabetes mellitus medulloblastoma osteosarcoma subependymal giant cell astrocytoma